Protein Alignment betaTub56D and TUBA4A

DIOPT Version :10

• Sequence 1: NP_725896.1
• Gene: betaTub56D / 37238
• FlyBaseID: FBgn0284243
• Length: 456
• Species: Drosophila melanogaster
• Sequence 2: XP_047301630.1
• Gene: TUBA4A / 7277
• HGNCID: 12407
• Length: 457
• Species: Homo sapiens
• Alignment Length: 433
• Identity: 173/433 - (39%)
• Similarity: 259/433 - (59%)
• Gaps: 16/433 - (3%)

  Fly    30 WEIISDEHGIDATGAYHGDSDL--QLERINVYYNEASGGKYVPRAVLVDLEPGTMDSVRSGPFGQ 92
            ||:...||||...|....|..:  ..:....::.|...||:|||||.|||||..:|.:|:||:.|
Human    30 WELYCLEHGIQPDGQMPSDKTIGGGDDSFTTFFCETGAGKHVPRAVFVDLEPTVIDEIRNGPYRQ 94

  Fly    93 IFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKEAESCDCLQGFQLTHSLGGGTGSGMG 157
            :|.|:..:.|:..|.||:|:||||.|.|::|.|||.:||.::.|..||||.:.||.|||||||..
Human    95 LFHPEQLITGKEDAANNYARGHYTIGKEIIDPVLDRIRKLSDQCTGLQGFLVFHSFGGGTGSGFT 159

  Fly   158 TLLISKIREEYPDRIMNTYSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFR 222
            :||:.::..:|..:....:|:.|:|:||..||||||:.|:.|..:|::|..:.:||||:||||.|
Human   160 SLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRR 224

  Fly   223 TLKLTTPTYGDLNHLVSLTMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGS 287
            .|.:..|||.:||.|:|..:|.:|..|||.|.||.||.:...|:||:||:||.:..:||:.|...
Human   225 NLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEK 289

  Fly   288 QQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNIQNKNSSYFVE 352
            ..:..|:|.|:|...|:..|.|..||||||:|:....::||.:..|:|:..:..|:.|.|..||:
Human   290 AYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIAAIKTKRSIQFVD 354

  Fly   353 WIPNNVKTAVCDIPP--------RGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTG 409
            |.|...|..:...||        ..::.:...:.|:|||.|.:.|:..:|..|:.::||:|||.|
Human   355 WCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVG 419

  Fly   410 EGMDEMEFTEAESNMNDLVSEYQQYQEATADEDAEFEEEQEAE 452
            |||:|.||:||..:|..|..:   |:|...|   .:|:|.|.|
Human   420 EGMEEGEFSEAREDMAALEKD---YEEVGID---SYEDEDEGE 456

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
betaTub56D	NP_725896.1	PLN00220	29..438	CDD:215107	168/417 (40%)
TUBA4A	XP_047301630.1	PTZ00335	11..457	CDD:185562	173/433 (40%)