DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment betaTub56D and alphaTub67C

DIOPT Version :9

Sequence 1:	NP_725896.1	Gene:	betaTub56D / 37238	FlyBaseID:	FBgn0284243	Length:	456	Species:	Drosophila melanogaster
Sequence 2:	NP_524009.2	Gene:	alphaTub67C / 39130	FlyBaseID:	FBgn0087040	Length:	462	Species:	Drosophila melanogaster

Alignment Length:	443	Identity:	169/443 - (38%)
Similarity:	257/443 - (58%)	Gaps:	27/443 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 WEIISDEHGIDATGAY--------HGDS-----DLQLERINVYYNEASGGKYVPRAVLVDLEPGT 81
            ||:...||||:..|:.        .|.|     |........::.|...||.|||::.|||||..
  Fly    21 WELYLLEHGINLDGSLKTKEELTASGSSASVGHDTSANDARTFFTETGNGKQVPRSIFVDLEPTV 85

  Fly    82 MDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKEAESCDCLQGFQLTH 146
            :|.||:|...:::.|:..:.|:..|.||:|:|.|:.|.|::|.|...::|.||.||.||||.:.|
  Fly    86 IDDVRNGCMRELYHPEQLISGKEDAANNYARGRYSIGKEVIDRVTSRLQKIAEQCDSLQGFLIFH 150

  Fly   147 SLGGGTGSGMGTLLISKIREEYPDRIMNTYSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCI 211
            |||||||||..:||:.::..:|..:....::|.||||||..|||||||.|:.|..::::|..:.:
  Fly   151 SLGGGTGSGFTSLLVERLSTDYSKKCKLDFAVYPSPKVSTAVVEPYNALLTTHSTMDHSDCVFMV 215

  Fly   212 DNEALYDICFRTLKLTTPTYGDLNHLVSLTMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFM 276
            ||||:||||..:|.:..|.|.:||.|::..:|..|..|||.|.:|.||.:...|:|||||:||.:
  Fly   216 DNEAIYDICNNSLGVDRPAYRNLNRLIAQIVSSTTASLRFSGSMNVDLNEFQTNLVPFPRIHFPL 280

  Fly   277 PGFAPLTS--RGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQM 339
            ..:|||.|  |.:.:..|:|.  ||...|::.|||..||||.|:::....::||.:..|:|:..:
  Fly   281 VAYAPLMSAERSAHEQHAITT--LTNACFESSNMMVKCDPRAGKFMACCMLYRGDVVPKDVNAAV 343

  Fly   340 LNIQNKNSSYFVEWIPNNVKTAV-----CDIPPRGL---KMSATFIGNSTAIQELFKRISEQFTA 396
            ..|::|....||:|.|...|..:     ..:|...|   ..:...:.|:|||...|..:|.:|..
  Fly   344 SAIKSKRHIQFVDWCPTGFKIGINYEKPAFVPDGDLAKTSRACCMLSNTTAISVAFSNLSYKFDL 408

  Fly   397 MFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQEATADE--DAEFEE 447
            ||:::||:|||.||||:|.|||||..|:..|..::::.....|:|  |.:|:|
  Fly   409 MFKKRAFVHWYVGEGMEEGEFTEARENIAVLERDFEEVGLDNAEEGGDEDFDE 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
betaTub56D	NP_725896.1	beta_tubulin	26..435	CDD:276956	164/427 (38%)
betaTub56D	NP_725896.1	PLN00220	29..438	CDD:215107	164/430 (38%)
alphaTub67C	NP_524009.2	alpha_tubulin	2..446	CDD:276955	164/426 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443471
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5023
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11588
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840