DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment betaTub56D and tbb-4

DIOPT Version :9

Sequence 1:	NP_725896.1	Gene:	betaTub56D / 37238	FlyBaseID:	FBgn0284243	Length:	456	Species:	Drosophila melanogaster
Sequence 2:	NP_509585.1	Gene:	tbb-4 / 181170	WormBaseID:	WBGene00006538	Length:	444	Species:	Caenorhabditis elegans

Alignment Length:	425	Identity:	399/425 - (93%)
Similarity:	419/425 - (98%)	Gaps:	1/425 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 FWEIISDEHGIDATGAYHGDSDLQLERINVYYNEASGGKYVPRAVLVDLEPGTMDSVRSGPFGQI 93
            |||:||||||||.||||:||||||||||||||||||||||||||.|||||||||||||:|||||:
Worm    20 FWEVISDEHGIDPTGAYNGDSDLQLERINVYYNEASGGKYVPRACLVDLEPGTMDSVRAGPFGQL 84

  Fly    94 FRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKEAESCDCLQGFQLTHSLGGGTGSGMGT 158
            ||||||||||||||||||||||||||||||:|||||||||||||||||||:||||||||||||||
Worm    85 FRPDNFVFGQSGAGNNWAKGHYTEGAELVDNVLDVVRKEAESCDCLQGFQMTHSLGGGTGSGMGT 149

  Fly   159 LLISKIREEYPDRIMNTYSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRT 223
            |||||||||||||||.|:||||||||||||||||||||||||||||||||:||||||||||||||
Worm   150 LLISKIREEYPDRIMMTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETFCIDNEALYDICFRT 214

  Fly   224 LKLTTPTYGDLNHLVSLTMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQ 288
            ||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||
Worm   215 LKLTTPTYGDLNHLVSMTMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQ 279

  Fly   289 QYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNIQNKNSSYFVEW 353
            |||:||||||||||||||||||||||||||||||||:||||||||||||||||:|||||||||||
Worm   280 QYRSLTVPELTQQMFDAKNMMAACDPRHGRYLTVAAMFRGRMSMKEVDEQMLNVQNKNSSYFVEW 344

  Fly   354 IPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFT 418
            ||||||||||||||||:||:|||:|||||||||||||||||||||||||||||||||||||||||
Worm   345 IPNNVKTAVCDIPPRGVKMAATFVGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFT 409

  Fly   419 EAESNMNDLVSEYQQYQEATADEDAEFEE-EQEAE 452
            ||||||||||||||||||||||::.||:| :|:.|
Worm   410 EAESNMNDLVSEYQQYQEATADDEGEFDEHDQDVE 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
betaTub56D	NP_725896.1	beta_tubulin	26..435	CDD:276956	387/405 (96%)
betaTub56D	NP_725896.1	PLN00220	29..438	CDD:215107	390/408 (96%)
tbb-4	NP_509585.1	PLN00220	1..444	CDD:215107	398/423 (94%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	415	1.000	Domainoid score	I331
eggNOG	1	0.900	-	-		E1_COG5023
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68504
Inparanoid	1	1.050	864	1.000	Inparanoid score	I210
Isobase	1	0.950	-	0	Normalized mean entropy	S24
OMA	1	1.010	-	-		QHG53784
OrthoDB	1	1.010	-	-		D259639at33208
OrthoFinder	1	1.000	-	-		FOG0000096
OrthoInspector	1	1.000	-	-		oto19679
orthoMCL	1	0.900	-	-		OOG6_100137
Panther	1	1.100	-	-	LDO	PTHR11588
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2834
SonicParanoid	1	1.000	-	-		X99
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.820