DRSC/TRiP Functional Genomics Resources

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Protein Alignment Fak and Tnk1

DIOPT Version :10

Sequence 1:NP_001137718.1 Gene:Fak / 37233 FlyBaseID:FBgn0020440 Length:1500 Species:Drosophila melanogaster
Sequence 2:NP_114086.3 Gene:Tnk1 / 83813 MGIID:1930958 Length:666 Species:Mus musculus


Alignment Length:514 Identity:148/514 - (28%)
Similarity:223/514 - (43%) Gaps:115/514 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   447 VRNYELDRALITPSAKIGVGQFGDVYVGTYTLPKLGKGKNLAGNGKNSNSDQRNADSRPDVIQVA 511
            ||..||          :|.|.||.|:.|.:|||          :|::              |.||
Mouse   116 VRRGEL----------LGSGCFGVVHRGLWTLP----------SGQS--------------IPVA 146

  Fly   512 IKTCKAN-DDPEKTE--NFLAEAYIMQKFDHPHIIRLIGICSVMPIWIVMELAKLGELRAYLKTN 573
            :|:.:.. :.|..||  :||.|..:|.|.:|||::||.|:....|:.:|||||.||.|.|.|...
Mouse   147 VKSLRVGPEGPMGTELGDFLREVSVMMKLEHPHVLRLHGLVLGQPLQMVMELAPLGSLHARLTAP 211

  Fly   574 SER--LSHGTLLKYCYQLSTALSYLESKKFVHRDIAARNVLVSSPTCVKLADFGLSRWVSDQ--S 634
            :..  |....|..:..||:.|::||.|...||||:|.||:|::||..:|:|||||.|.:...  .
Mouse   212 APTPPLPVALLCLFLRQLAGAMAYLGSCGLVHRDLATRNLLLASPRMIKVADFGLVRPLGGARGR 276

  Fly   635 YYHSTPTVALPIKWMSPESINFRRFTTASDVWMFGVCIWEILMLGVKPFQGVKNSDVILKLENGE 699
            |....|. .:|..|.:|||:....|::|||||||||.:||:...|.:|:.||....::.:||...
Mouse   277 YVMGGPR-PIPYAWCAPESLRQGAFSSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEKDR 340

  Fly   700 -RLPLPPNCPPRLYSLMSQCWAYEPLKRPNFKRIKETLHEILIED-----SINSSETLKRE---- 754
             |||.||.|...||||..:|||..|..||:|..::..|.|..:.:     .:.....|:.|    
Mouse   341 ARLPKPPLCSRALYSLALRCWAPHPADRPSFSNLEGLLQEAWLSEGRCVREVTEPGALRMEPGDP 405

  Fly   755 ----QRKVASMSWIGSDDIDIPPSKPSRVMHDPDITGLMPETTGLPQTYIIAQN----------- 804
                :..:.:.:|.|.:      .:..:|.:.|.....:.:..|.|.|:...:.           
Mouse   406 ITIIEGSLDTATWKGQN------GRTLKVGNFPASAVTLADLGGSPVTHPAHRGSPAHGEKCRGG 464

  Fly   805 --------------PAVLAKLMMENQK-RGINPAAYTTPASVFNTLAVGL----DDSNPNVSLKT 850
                          ||...:..|..|: |||:       .|:.:.|::|.    ..|:|....:|
Mouse   465 TDGDREKATLQDLPPARSHRTKMPLQRMRGIS-------KSLESVLSLGPRPTGGGSSPPELRRT 522

  Fly   851 TKLPAADLLKLDPIAESERLRSQFSANSSASQLANPLTASVNPH------ESLNSHQAG 903
            ..:|.. |..|.|.......|.....|||         ....||      ||.::|:.|
Mouse   523 RAMPQR-LPDLPPRPPDLPPRPPIICNSS---------QPTQPHKARPKRESSHNHRTG 571

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FakNP_001137718.1 B41 24..267 CDD:214604
FERM_B-lobe 152..257 CDD:271216
FERM_C_FAK1 263..394 CDD:270011
PTKc_FAK 450..744 CDD:133187 110/306 (36%)
Focal_AT 1250..1376 CDD:460992
Tnk1NP_114086.3 SAM_TNK-like 16..67 CDD:188938
Protein Kinases, catalytic domain 120..380 CDD:473864 109/294 (37%)
SH3 <395..436 CDD:473055 6/46 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 442..589 30/147 (20%)
UBA_like_SF 594..637 CDD:473871
UBA_like_SF 624..663 CDD:473871
Blue background indicates that the domain is not in the aligned region.

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