DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fak and ptk2

DIOPT Version :9

Sequence 1:	NP_001137718.1	Gene:	Fak / 37233	FlyBaseID:	FBgn0020440	Length:	1500	Species:	Drosophila melanogaster
Sequence 2:	XP_004915083.1	Gene:	ptk2 / 733890	XenbaseID:	XB-GENE-952025	Length:	1134	Species:	Xenopus tropicalis

Alignment Length:	1371	Identity:	429/1371 - (31%)
Similarity:	622/1371 - (45%)	Gaps:	405/1371 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 IRRTVEDLGTDGRTPSIQRYACRMLNMITKEVIWLARSTSMQKVLSHILTPGCSNVDCPNNQSEL 112
            :|..::.:....:..::..:..|:.::.::||.||....            |.|:|.....||..
Frog   118 VRGIIQKIVDSHKVKNVASFGLRLSHLHSEEVHWLHPDM------------GVSHVREKYEQSHP 170

  Fly   113 DEVLLEHGRRITDNRVWRVELRVRYVPNNIQELFEEDKATCFYYFNQVKEDFIQANVTAIDTEVA 177
            .|             .|:.|||:||:|......|.|||.|..:::.|||.|::......:|.|:|
Frog   171 PE-------------EWKYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKNDYMSEIADQVDQEIA 222

  Fly   178 VQLCCLGIRHYFKNITVKAPDKKQHIDYIEKEIGFKSFLPQSVIATSKPKNLKKLIQVGYKKVYN 242
            ::|.||.||..:..:...|.:||.:.:.:||::|.|.|.|:|::.:.|.|.|:||||..:::..|
Frog   223 LKLGCLEIRRSYGEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKAKTLRKLIQQTFRQFAN 287

  Fly   243 YNDIEYLTRFFDLLKNIYLTNFEQFSVTLSSAWNISGILHVGPHIGISYQTHPQASLKNVAQFKD 307
            .|..|.:.:||::|..:|..:.|.|...|.|:|.||..|.:||..||||.|...::..::|.|..
Frog   288 LNREESILKFFEILSPVYRYDKECFKCALGSSWIISVELAIGPEEGISYLTDKGSNPTHLADFTQ 352

  Fly   308 VVSIKTCTLPKEKLSKSGENTTEPELQNFNCNCQKIKTQIKISASNNVEDLVITCNGINTAESIA 372
            |.:|        :.|.|.|..            :|...|:||:.:  .|.|.:|...:..||::|
Frog   353 VQTI--------QYSSSEEKD------------RKGMLQLKIAGA--PEPLTVTAPSLTIAENMA 395

  Fly   373 DLIDGYCRLLSKDLEFTIWHRETNASNEDSAKALPNDATLGSNK---------STSSQGKPMLTD 428
            |||||||||:|...|..|...:     ::..:|||:...|.:::         |.|.:.....||
Frog   396 DLIDGYCRLVSGASESFIIRPQ-----KEGERALPSIPKLANSEKHGVRAHAVSVSDEFSGDETD 455

  Fly   429 DYAEIGLLEGEGDYSTPTVR-------------------NYELDRALITPSAKIGVGQFGDVYVG 474
            |||||  ::.|..|:.|:..                   :||:.|..|.....||.||||||:.|
Frog   456 DYAEI--IDEEDTYTMPSTEVVSFFMTGILESYGLDEAGDYEIQRERIELGRCIGEGQFGDVHQG 518

  Fly   475 TYTLPKLGKGKNLAGNGKNSNSDQRNADSRPDVIQVAIKTCKANDDPEKTENFLAEAYIMQKFDH 539
            .|..|:                       .| .:.|||||||........|.||.||..|::|||
Frog   519 VYMSPE-----------------------NP-AMAVAIKTCKNCTSDSVREKFLQEALTMRQFDH 559

  Fly   540 PHIIRLIGICSVMPIWIVMELAKLGELRAYLKTNSERLSHGTLLKYCYQLSTALSYLESKKFVHR 604
            |||::|||:.:..|:||:|||..|||||::|:.....|...:|:.|.|||||||:|||||:||||
Frog   560 PHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHR 624

  Fly   605 DIAARNVLVSSPTCVKLADFGLSRWVSDQSYYHSTPTVALPIKWMSPESINFRRFTTASDVWMFG 669
            |||||||||||..||||.||||||::.|.:||.::.. .||||||:||||||||||:||||||||
Frog   625 DIAARNVLVSSSDCVKLGDFGLSRYMEDSTYYKASKG-KLPIKWMAPESINFRRFTSASDVWMFG 688

  Fly   670 VCIWEILMLGVKPFQGVKNSDVILKLENGERLPLPPNCPPRLYSLMSQCWAYEPLKRPNFKRIKE 734
            ||:|||||.|:||||||||:|||.::|||||||:||||||.|||||::||||:|.:||.|..:|.
Frog   689 VCMWEILMYGIKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKA 753

  Fly   735 TLHEILIEDSINSSETLKREQRKVASMSWI--GSDDIDIPPSKPSRVMHDPDITGLMPETTGLPQ 797
            .|..||.|:.:...|.::.|.|:..::||.  |||:   .|.||||
Frog   754 QLSTILEEEKLQQEERMRMESRRQVTVSWDSGGSDE---APPKPSR------------------- 796

  Fly   798 TYIIAQNPAVLAKLMMENQKRGINPAAYTTPASVFNTLAVGLDDSNPNVSLKTTKLPAADLLKLD 862
                                     ..|.:|.|
Frog   797 -------------------------PGYPSPRS-------------------------------- 804

  Fly   863 PIAESERLRSQFSANSSASQLANPLTASVNPHESLNSHQAGMFTGSLPSKSSFVVCPPQTEEHMQ 927
                ||                                      |..||        ||   ||
Frog   805 ----SE--------------------------------------GFFPS--------PQ---HM- 815

  Fly   928 AENISNPSVSKVSGYSLYGSLERHQPPPAKAMHSKGGSLERHQSLMSAQNLVFYNTKPPPNCTNT 992
                ..|:..:|||:|:     .|..|      |..|:|.                   |...:.
Frog   816 ----VQPNHYQVSGFSI-----SHGIP------SMSGNLY-------------------PGQASV 846

  Fly   993 AERSRSMERNTYFHAYRQQMKTSIECEALPEEIYDFGGIGLKTCVSARQQPKFSPMVNV-RPAEL 1056
            .:...|....|                                           |.:|: :|
Frog   847 IDHMDSWNHRT-------------------------------------------PDINMWQP--- 865

  Fly  1057 GQVQNTDCMGLQQNIPMD--SFGVISP-HNLDESL-RHQREME--RQWMTSGPQSITVNPNISIS 1115
                     |::.:.|||  |...:.| |.::|.| |.|:|||  ::|:..  :...:.|::.:|
Frog   866 ---------GMEDSGPMDLRSMAQVLPTHLMEERLIRQQQEMEEDQRWLEK--EERFLKPDVRLS 919

  Fly  1116 EGAA--CLATLQAEAMGNQGIHNVLGEKLRQQQKDSNSDSEWLIQEELLRSCSIPQGSLNDHQAQ 1178
            .|:.  ....||..| |||.|:..:|:.                                ||
Frog   920 RGSVDHVDGNLQCPA-GNQHIYQPVGKP--------------------------------DH--- 948

  Fly  1179 MFKLDFMSAGPSSLPDCSNSSSRPMTPNANLSSLKSNHSSADHLSSLTSAEEQMGSNARNLGSAV 1243
                   ||.|...|       ||..| ::|.:|.:::|..|..:.        |.....:....
Frog   949 -------SAPPKKPP-------RPGAP-SHLGNLPAHNSPVDSYNE--------GVKPWRIQPQE 990

  Fly  1244 PSRPP----NRADDEVYCATTLVVKSIMALSQGVEKANTEGYLELVKNVGVKLRNLLTSVDKISI 1304
            .|.||    :|.:|:||...|.:||:::.:|..::.|..|.|:.:||.||:.||.||.:||:...
Frog   991 ISPPPTANLDRTNDKVYENVTGLVKAVIEMSSRIQPAPPEEYVPMVKGVGLALRTLLATVDETIP 1055

  Fly  1305 IFPAQALKEVQMAHQVLSKDMHELVSAMRLAQQYSDTTLDCEYRKSMLSAAHVLAMDAKNLFDVV 1369
            :.||...:|::||.::|:.|:.||::.|:|||||..|:|..||:|.||:|||.||:|||||.||:
Frog  1056 VLPASTHREIEMAQKLLNSDLAELINKMKLAQQYVMTSLQQEYKKQMLTAAHALAVDAKNLLDVI 1120

  Fly  1370 DSIRQR 1375
            |..|.|
Frog  1121 DQARLR 1126

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fak	NP_001137718.1	B41	24..267	CDD:214604	61/218 (28%)
		FERM_B-lobe	152..257	CDD:271216	35/104 (34%)
		FERM_C_FAK1	263..394	CDD:270011	44/130 (34%)
		PTKc_FAK	450..744	CDD:133187	167/293 (57%)
		Pkinase_Tyr	462..736	CDD:285015	159/273 (58%)
		Focal_AT	1249..1376	CDD:281606	58/127 (46%)
ptk2	XP_004915083.1	B41	90..312	CDD:214604	61/218 (28%)
		FERM_B-lobe	197..302	CDD:271216	35/104 (34%)
		FERM_C_FAK1	308..418	CDD:270011	44/136 (32%)
		PTKc_FAK	494..758	CDD:133187	164/288 (57%)
		Pkinase_Tyr	501..755	CDD:285015	160/278 (58%)
		Focal_AT	998..1127	CDD:281606	58/129 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	324	1.000	Domainoid score	I1200
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H7314
Inparanoid	1	1.050	633	1.000	Inparanoid score	I826
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D29350at33208
OrthoFinder	1	1.000	-	-		FOG0002650
OrthoInspector	1	1.000	-	-		otm49324
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1755
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060