DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Fak and TYK2

DIOPT Version :10

Sequence 1:NP_001137718.1 Gene:Fak / 37233 FlyBaseID:FBgn0020440 Length:1500 Species:Drosophila melanogaster
Sequence 2:NP_001372133.1 Gene:TYK2 / 7297 HGNCID:12440 Length:1257 Species:Homo sapiens


Alignment Length:334 Identity:101/334 - (30%)
Similarity:153/334 - (45%) Gaps:60/334 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   431 AEIGLLEGEGDYSTPTVRNYELDRALITPSAKIGVGQFGDVYVGTYTLPKLGKGKNLAGNGKNSN 495
            |::..:..:...|.|||    ..:..:.....:|.|.||.|.:..|.....|.|:          
Human   945 ADVLTVNPDSPASDPTV----FHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGE---------- 995

  Fly   496 SDQRNADSRPDVIQVAIKTCKANDDPEKTENFLAEAYIMQKFDHPHIIRLIGIC---SVMPIWIV 557
                         .||:|..||:..|:....:..|..|::...|.|||:..|.|   ....:.:|
Human   996 -------------MVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLV 1047

  Fly   558 MELAKLGELRAYLKTNSERLSHGTLLKYCYQLSTALSYLESKKFVHRDIAARNVLVSSPTCVKLA 622
            ||...||.||.||..:|..|:.  ||.:..|:...::||.::.::|||:||||||:.:...||:.
Human  1048 MEYVPLGSLRDYLPRHSIGLAQ--LLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIG 1110

  Fly   623 DFGLSRWVSD-QSYYHSTPTVALPIKWMSPESINFRRFTTASDVWMFGVCIWEIL---------- 676
            ||||::.|.: ..||........|:.|.:||.:...:|..|||||.|||.::|:|          
Human  1111 DFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPP 1175

  Fly   677 -----MLGVKPFQGVKNSDVILK----LENGERLPLPPNCPPRLYSLMSQCWAYEPLKRPNFKR- 731
                 ::|:     .:....:|:    ||.|||||.|..||..:|.||..||..|...||.|:. 
Human  1176 TKFLELIGI-----AQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENL 1235

  Fly   732 --IKETLHE 738
              |.:|:||
Human  1236 IPILKTVHE 1244

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FakNP_001137718.1 B41 24..267 CDD:214604
FERM_B-lobe 152..257 CDD:271216
FERM_C_FAK1 263..394 CDD:270011
PTKc_FAK 450..744 CDD:133187 96/315 (30%)
Focal_AT 1250..1376 CDD:460992
TYK2NP_001372133.1 FERM_F1 28..125 CDD:465733
FERM_F2 143..266 CDD:436450
Jak1_Phl 285..432 CDD:465552
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 335..366
SH2 437..534 CDD:472789
Protein Kinases, catalytic domain 589..937 CDD:473864
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 610..629
PTKc_Tyk2_rpt2 962..1244 CDD:270664 94/311 (30%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.