DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fak and ptk2ba

DIOPT Version :9

Sequence 1:	NP_001137718.1	Gene:	Fak / 37233	FlyBaseID:	FBgn0020440	Length:	1500	Species:	Drosophila melanogaster
Sequence 2:	XP_005158634.1	Gene:	ptk2ba / 557258	ZFINID:	ZDB-GENE-080207-1	Length:	933	Species:	Danio rerio

Alignment Length:	1380	Identity:	362/1380 - (26%)
Similarity:	538/1380 - (38%)	Gaps:	507/1380 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 KSFKAVR----FNVKETVFHVIRRTVEDLGTDGRTPSIQRYAC---RMLNMITKEVIWLARSTSM 88
            |:||.|:    :|::..:     :.:.|.|..|  |:|:.:.|   .:.::.:.||.||....::
Zfish    35 KNFKLVKCESSWNIRSII-----KAILDSGRLG--PNIKCFECYGLMLKHLKSDEVHWLHPKLTV 92

  Fly    89 QKVLSHILTPGCSNVDCPNNQSELDEVLLEHGRRITDNRVWRVELRVRYVPNNIQELFEEDKATC 153
            .:|               ..:.|...|..|          ||.:||:||:|::..|..::||.|.
Zfish    93 AEV---------------EQKYEQQHVEAE----------WRYDLRIRYIPSDFLEKLKDDKTTM 132

  Fly   154 FYYFNQVKEDFIQANVTAIDTEVAVQLCCLGIRHYFKNITVKAPDKKQHIDYIEKEIGFKSFLPQ 218
            .|::.||:.|::|.|...:...:|:||.||.||.::|::.....:||.:.:.:||::|...|.|.
Zfish   133 LYFYQQVRADYMQHNARRVSDGMALQLGCLEIRRFYKDMNASGLEKKSNFELLEKDVGLDLFFPP 197

  Fly   219 SVIATSKPKNLKKLIQVGYKKVYNYNDIEYLTRFFDLLKNIYLTNFEQFSVTLSSAWNISGILHV 283
            .:|.:.|||:|:|:||..:.:.....:.:.:.:||:.|......:.|.|...|...|::|..|.:
Zfish   198 ELIDSMKPKHLRKMIQQTFLQFAMLKEEQCIIKFFETLSVFSSFDEEVFPCELVQGWSVSVDLVI 262

  Fly   284 GPHIGISYQTHPQASLKNVAQFKDVVSIKTCTLPKEKLSKSGENTTEPELQNFNCNCQKIKTQIK 348
            ||. ||..:|...:...::|.|..:.||| ||...:.                       |..:.
Zfish   263 GPK-GIRQRTDKISVPVSLATFSQIRSIK-CTHQNDG-----------------------KALLH 302

  Fly   349 ISASNNVEDLVITCNGINTAESIADLIDGYCRL-LSKDLEFTIWHRETNASNEDSAKALPNDATL 412
            |:.....:.|.|:...:..||::|||||||||| ...:....:|..:...| .:|...||
Zfish   303 INIEGAKQPLSISTASLALAENMADLIDGYCRLEQGNEKTLIVWPNKDRES-RNSLPPLP----- 361

  Fly   413 GSNKSTSSQGKPMLTDDYAEIGLLEGEGDYSTPTVR-----NYELDRALITPSAKIGVGQFGDVY 472
            ||.::|:|..:...:|.||||           |..:     .:.:.|..|.....:|.|.||:|:
Zfish   362 GSKENTTSHKEGKNSDIYAEI-----------PEEKPLAACKFSISRNDIVLGRILGEGFFGEVH 415

  Fly   473 VGTYTLPKLGKGKNLAGNGKNSNSDQRNADSRPDVIQVAIKTCKANDDPEKTENFLAEAYIMQKF 537
            .|.|                .|.|.:|        :.||:|||| :...:..|.|::||.||:|.
Zfish   416 DGIY----------------KSKSGER--------VNVAVKTCK-DCSADVKEKFMSEALIMKKL 455

  Fly   538 DHPHIIRLIGICSVMPIWIVMELAKLGELRAYLKTNSERLSHGTLLKYCYQLSTALSYLESKKFV 602
            |||||:|||||....|:||||||...|||..|||.|..:|::.||:.|..|:|.||:|||....|
Zfish   456 DHPHIVRLIGIIEEDPVWIVMELYPFGELENYLKDNQNKLTNVTLILYSLQISKALAYLEGVNMV 520

  Fly   603 HRDIAARNVLVSSPTCVKLADFGLSRWVSDQSYYHSTPTVALPIKWMSPESINFRRFTTASDVWM 667
            |||||.|||||:...||||.||||||::.::.||.::.| .||||||:||||||||||:||||||
Zfish   521 HRDIAVRNVLVAKVDCVKLGDFGLSRYIEEEEYYKASVT-RLPIKWMAPESINFRRFTSASDVWM 584

  Fly   668 FGVCIWEILMLGVKPFQGVKNSDVILKLENGERLPLPPNCPPRLYSLMSQCWAYEPLKRPNFKRI 732
            |.||:|||:..|.:||..::|.|||.:||.|.|||.|..|||.|||||::||:|.|..||:|..:
Zfish   585 FAVCMWEIMSGGQQPFFWLENKDVINQLEQGMRLPKPERCPPTLYSLMTRCWSYSPRDRPSFTEL 649

  Fly   733 KETLHEI-LIEDSINSSETLKREQRKVASMSWIGSDDIDIPPSKPSRVMHDPDITGLMPETTGLP 796
            ...|.:: .:|..:...| |:...|.:...::     .|.|| ||||:
Zfish   650 VCKLSDVHKLEQEVEVEE-LRARSRTINISAF-----PDAPP-KPSRM----------------- 690

  Fly   797 QTYIIAQNPAVLAKLMMENQKRGINPAAYTTPASVFNTLAVGLDDSNPNVSLKTTKLPAADLLKL 861
                                   |.|.        ||||
Zfish   691 -----------------------IPPG--------FNTL-------------------------- 698

  Fly   862 DPIAESERLRSQFSANSSASQLANPLTASVNPHESLNSHQAGMFTGSLPSKSSFVVCPPQTEEHM 926
                 |.||                                                      ::
Zfish   699 -----SPRL------------------------------------------------------NV 704

  Fly   927 QAENISNPSVSKVSGYSLYGSLERHQPPPAKAMHSKGGSLERHQSLMSAQNLVFYNTKPPPNCTN 991
            ||..:..||                    :||
Zfish   705 QARGVQEPS--------------------SKA--------------------------------- 716

  Fly   992 TAERSRSMERNTYFHAYRQQMKTSIECEALPEEIYDFGGIGLKTCVSARQQPKFSPMVNVRPAEL 1056
            .|:|...:||.
Zfish   717 DAQRLWDVERQ------------------------------------------------------ 727

  Fly  1057 GQVQNTDCMGLQQNIPMDSFGVISPHNLDESLRHQREMERQWMTSGPQSITVNPNISISEGAACL 1121
             |||.|
Zfish   728 -QVQET----------------------------------------------------------- 732

  Fly  1122 ATLQAEAMGNQGIHNVLGEKLRQQQKDSNSDSEWLIQEELLRSCSIPQGSLNDHQAQMFKLDFMS 1186
                                ||:|:::...|.:||.:||.|
Zfish   733 --------------------LRRQKQEMLEDHQWLEKEEKL------------------------ 753

  Fly  1187 AGPSSLPDCSNSSSRPMTPNANLSSLKSNHSSADHLSSLTSAEEQMGSNARNLGSAVPSRPP--- 1248
                            :.|.|| ..:|:..::.:....::|             ...|.:||
Zfish   754 ----------------LVPFAN-EDMKTKATTENDTGQVSS-------------QGPPEKPPRVS 788

  Fly  1249 ---------NRADDEVYCATTLVVKSIMALSQGVEKANTEGYLELVKNVGVKLRNLLTSVDKISI 1304
                     :|.||.||.....:||.::.|...|.......|:.:||:||:.||:|:.|||.|..
Zfish   789 AQPAPTAELDRTDDLVYQNVMEMVKVVVQLKNQVNTLPASEYVSVVKSVGMTLRSLIHSVDDILP 853

  Fly  1305 IFPAQALKEVQMAHQVLSKDMHELVSAMRLAQQYSDTTLDCEYRKSMLSAAHVLAMDAKNLFDVV 1369
            ........|::...::|:||:.||:|.||||||.|.|:|..|.:|.||:|||.||||:|||.|.|
Zfish   854 SLHESIRTEIEGTQKLLNKDLAELISKMRLAQQNSVTSLKDECKKQMLAAAHTLAMDSKNLLDAV 918

  Fly  1370 DSIRQRYQHLFPPSA 1384
            |..|.|.....|.|:
Zfish   919 DQARVRANTARPASS 933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fak	NP_001137718.1	B41	24..267	CDD:214604	63/242 (26%)
		FERM_B-lobe	152..257	CDD:271216	32/104 (31%)
		FERM_C_FAK1	263..394	CDD:270011	35/131 (27%)
		PTKc_FAK	450..744	CDD:133187	143/294 (49%)
		Pkinase_Tyr	462..736	CDD:285015	139/273 (51%)
		Focal_AT	1249..1376	CDD:281606	55/126 (44%)
ptk2ba	XP_005158634.1	B41	33..246	CDD:214604	63/242 (26%)
		FERM_C_FAK1	242..351	CDD:270011	35/133 (26%)
		PKc_like	393..657	CDD:328722	142/289 (49%)
		Focal_AT	796..925	CDD:308942	55/128 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	115	1.000	Domainoid score	I5966
eggNOG	1	0.900	-	-		E1_KOG4257
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	628	1.000	Inparanoid score	I834
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D29350at33208
OrthoFinder	1	1.000	-	-		FOG0002650
OrthoInspector	1	1.000	-	-		otm26029
orthoMCL	1	0.900	-	-		OOG6_105566
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1755
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.730