Protein Alignment Fak and Ptk2b

DIOPT Version :9

• Sequence 1: NP_001137718.1
• Gene: Fak / 37233
• FlyBaseID: FBgn0020440
• Length: 1500
• Species: Drosophila melanogaster
• Sequence 2: NP_059014.2
• Gene: Ptk2b / 50646
• RGDID: 628758
• Length: 1009
• Species: Rattus norvegicus
• Alignment Length: 1383
• Identity: 373/1383 - (26%)
• Similarity: 560/1383 - (40%)
• Gaps: 454/1383 - (32%)

  Fly    29 PNKSFKAVRFNVKETVFHVIRRTVEDLGTDGRT-PSIQR---YACRMLNMITKEVIWLARSTSMQ 89
            |.|:||.|:..|:..:..:|...:    ..||. |:||.   |..|:.:|.:.|:.||....::.
  Rat    52 PGKNFKLVKCTVQTEIQEIITSIL----LSGRIGPNIQLAECYGLRLKHMKSDEIHWLHPQMTVG 112

  Fly    90 KVLSHILTPGCSNVDCPNNQSELDEVLLEHGRRITDNRVWRVELRVRYVPNNIQELFEEDKATCF 154
            :|.        ...:|.:.::|                 ||.:|::||:|.:..|..:||:.|..
  Rat   113 EVQ--------DKYECLHVEAE-----------------WRYDLQIRYLPEDFMESLKEDRTTLL 152

  Fly   155 YYFNQVKEDFIQANVTAIDTEVAVQLCCLGIRHYFKNITVKAPDKKQHIDYIEKEIGFKSFLPQS 219
            |::.|::.|::|...:.:...:|:||.||.:|.:||::...|.|||.:.:.:|||:|...|.|:.
  Rat   153 YFYQQLRNDYMQRYASKVSEGMALQLGCLELRRFFKDMPHNALDKKSNFELLEKEVGLDLFFPKQ 217

  Fly   220 VIATSKPKNLKKLIQVGYKKVYNYNDIEYLTRFFDLLKNIYLTNFEQFSVTLSSAWNISGILHVG 284
            :....|||..:|:||..:::..:..:.|.:.:||:.|......:.|.:...|...|||:..|.:|
  Rat   218 MQENLKPKQFRKMIQQTFQQYASLREEECVMKFFNTLAGFANIDQETYRCELIQGWNITVDLVIG 282

  Fly   285 PHIGISYQTHPQASLKNVAQFKDVVSIKTCTLPKEKLSKSGENTTEPELQNFNCNCQKIKTQIKI 349
            |. ||...|........:|:||.:.||: | ||.|:        |:..||              :
  Rat   283 PK-GIRQLTSQDTKPTCLAEFKQIRSIR-C-LPLEE--------TQAVLQ--------------L 322

  Fly   350 SASNNVEDLVITCNGINTAESIADLIDGYCRLLSKDLEFTIWHRETNASNEDSAKALPNDATLGS 414
            ......:.|.|..:.:..||::||||||||||..:.....|.|.:.:....:|...:|. ..|.|
  Rat   323 GIEGAPQSLSIKTSSLAEAENMADLIDGYCRLQGEHKGSLIIHAKKDGEKRNSLPQIPT-LNLES 386

  Fly   415 NKSTSSQGKPMLTDDYAEIGLLEGEGDYSTPTVRNYELDRALITPSAKIGVGQFGDVYVGTYTLP 479
            .:|..|:...:.:|.||||    .:.....|....|.:.|..:..:..:|.|.||:||.|.||
  Rat   387 RRSHLSESCSIESDIYAEI----PDETLRRPGGPQYGVAREDVVLNRILGEGFFGEVYEGVYT-- 445

  Fly   480 KLGKGKNLAGNGKNSNSDQRNADSRPDVIQVAIKTCKANDDPEKTENFLAEAYIMQKFDHPHIIR 544
                                  :.:.:.|.||:||||.:...:..|.|::||.||:..|||||::
  Rat   446 ----------------------NHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHIVK 488

  Fly   545 LIGICSVMPIWIVMELAKLGELRAYLKTNSERLSHGTLLKYCYQLSTALSYLESKKFVHRDIAAR 609
            ||||....|.||||||...|||..||:.|...|...||:.|..|:..|::||||...||||||.|
  Rat   489 LIGIIEEEPTWIVMELYPYGELGHYLERNKNSLKVPTLVLYALQICKAMAYLESINCVHRDIAVR 553

  Fly   610 NVLVSSPTCVKLADFGLSRWVSDQSYYHSTPTVALPIKWMSPESINFRRFTTASDVWMFGVCIWE 674
            |:||:||.||||.||||||::.|:.||.::.| .|||||||||||||||||||||||||.||:||
  Rat   554 NILVASPECVKLGDFGLSRYIEDEDYYKASVT-RLPIKWMSPESINFRRFTTASDVWMFAVCMWE 617

  Fly   675 ILMLGVKPFQGVKNSDVILKLENGERLPLPPNCPPRLYSLMSQCWAYEPLKRPNFKRIKETL--- 736
            ||..|.:||..::|.|||..||.|:|||.|..|||.||:||::||.|:|..||.|..:..:|
  Rat   618 ILSFGKQPFFWLENKDVIGVLEKGDRLPKPELCPPVLYTLMTRCWDYDPSDRPRFTELVCSLSDI 682

  Fly   737 ----HEILIEDSINSSETLKREQRKVASMSWIGSDDIDIPPSKPSRVMHDPDITGLMPETTGLPQ 797
                .:|.||...|:.....:.....|...         ||.||||           |:....||
  Rat   683 YQMERDIAIEQERNARYRPPKILEPTAFQE---------PPPKPSR-----------PKYKHPPQ 727

  Fly   798 TYIIAQNPAVLAKLMMENQKRGINPAAYTTPASVFNTLAVGLDDSNPNVSLKTTKLPAADLLKLD 862
            |.::|      .||..:                    :..||..|:|.
  Rat   728 TNLLA------PKLQFQ--------------------VPEGLCASSPT----------------- 749

  Fly   863 PIAESERLRSQFSANSSASQLANPLTASVNPHESLNSHQAGMFTGSLPSKSSFVVCPPQTEEHMQ 927
                                |.:|:
  Rat   750 --------------------LTSPM---------------------------------------- 754

  Fly   928 AENISNPSVSKVSGYSLYGSLERHQPPPAKAMHSKGGSLERHQSLMSAQNLVFYNTKPPPNCTNT 992
                                   ..|.|..::|:                       ||.:..|.
  Rat   755 -----------------------EYPSPVNSLHT-----------------------PPLHRHNV 773

  Fly   993 AERSRSMERNTYFHAYRQQMKTSIECEALPEEIYDFGGIGLKTCVSARQQPKFSPMVNVRPAELG 1057
            .:|          |:.|::               ||                      :||:.
  Rat   774 FKR----------HSMREE---------------DF----------------------IRPSS-- 789

  Fly  1058 QVQNTDCMGLQQNIPMDSFGVISPHNLDESLRHQREMERQWMTSGPQSITVNPNISISEGAACLA 1122
                                             :.|.::.|
  Rat   790 ---------------------------------REEAQQLW------------------------ 797

  Fly  1123 TLQAEAMGNQGIHNVLGEKLRQ----QQKDSNSDSEWLIQEELLRSCSIPQGSLNDHQAQMFKLD 1183
              :||.:           |:||    |||....||:||.:||   .|..|...:||
  Rat   798 --EAEKI-----------KMRQVLDRQQKQMVEDSQWLRREE---RCLDPMVYMND--------- 837

  Fly  1184 FMSAGPSSLPDCSNSSSRPMTPNANLSSLKSNHSSADHLSSLTSAEEQMGSNARNLGSAVPSRPP 1248
                            ..|:||                       |::.|...   .:..|.:||
  Rat   838 ----------------KSPLTP-----------------------EKEAGYTE---FTGPPQKPP 860

  Fly  1249 -------------NRADDEVYCATTLVVKSIMALSQGVEKANTEGYLELVKNVGVKLRNLLTSVD 1300
                         :|.||.||.....:|::::.|...:.:...|.|:.:|||||:.||.|:.|||
  Rat   861 RLGAQSIQPTANLDRTDDLVYHNVMTLVEAVLELKNKLSQLPPEEYVVVVKNVGLNLRKLIGSVD 925

  Fly  1301 KISIIFPAQALKEVQMAHQVLSKDMHELVSAMRLAQQYSDTTLDCEYRKSMLSAAHVLAMDAKNL 1365
            .:....||.:..|::...::|:||:.||::.||||||.:.|:|..:.::.||:|:|.||:|||||
  Rat   926 DLLPSLPASSRTEIEGTQKLLNKDLAELINKMRLAQQNAVTSLSEDCKRQMLTASHTLAVDAKNL 990

  Fly  1366 FDVVDSIRQRYQHLFPPS 1383
            .|.||..:.......||:
  Rat   991 LDAVDQAKVVANLAHPPA 1008

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fak	NP_001137718.1	B41	24..267	CDD:214604	64/241 (27%)
		FERM_B-lobe	152..257	CDD:271216	32/104 (31%)
		FERM_C_FAK1	263..394	CDD:270011	39/130 (30%)
		PTKc_FAK	450..744	CDD:133187	145/300 (48%)
		Pkinase_Tyr	462..736	CDD:285015	139/273 (51%)
		Focal_AT	1249..1376	CDD:281606	50/126 (40%)
Ptk2b	NP_059014.2	FERM_N_2	39..137	CDD:407875	26/113 (23%)
		B41	41..254	CDD:214604	62/230 (27%)
		FERM_C_FAK1	261..368	CDD:270011	39/131 (30%)
		PTKc_FAK	418..687	CDD:133187	142/293 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	702..725		8/42 (19%)
		Interaction with TGFB1I1. /evidence=ECO:0000269|PubMed:9422762	801..1009		76/273 (28%)
		Focal adhesion targeting (FAT)	868..1009		52/141 (37%)
		Focal_AT	872..1001	CDD:397606	50/128 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	118	1.000	Domainoid score	I5709
eggNOG	1	0.900	-	-		E1_KOG4257
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	651	1.000	Inparanoid score	I754
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D29350at33208
OrthoFinder	1	1.000	-	-		FOG0002650
OrthoInspector	1	1.000	-	-		otm46241
orthoMCL	1	0.900	-	-		OOG6_105566
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1755
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.730