DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fak and ptk2b

DIOPT Version :9

Sequence 1:	NP_001137718.1	Gene:	Fak / 37233	FlyBaseID:	FBgn0020440	Length:	1500	Species:	Drosophila melanogaster
Sequence 2:	XP_012819490.1	Gene:	ptk2b / 496459	XenbaseID:	XB-GENE-489525	Length:	1017	Species:	Xenopus tropicalis

Alignment Length:	1404	Identity:	388/1404 - (27%)
Similarity:	586/1404 - (41%)	Gaps:	435/1404 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TAGATSQPP------PTKNEINSEEYLI-----HVHMPN--KSFKAVRFNVKETVFHVIRRTVED 54
            |.|.|...|      |.:.||:.||..|     |.:..|  |:||.    ||.:::..|:..:..
Frog     9 TKGGTFNRPDGPAEVPAEVEISKEEMRILKVCFHSNSSNLVKNFKL----VKCSIYTDIQEIISS 69

  Fly    55 LGTDGRT-PSIQRYAC---RMLNMITKEVIWLARSTSMQKVLSHILTPGCSNVDCPNNQSELDEV 115
            :...||. |.|:...|   |:.::.:.|:.||....::.:|.        ...:|.:.::|
Frog    70 ILLSGRIGPDIKHVECYGLRLKHLKSDEIHWLHPELTVGEVQ--------EKYECLHLEAE---- 122

  Fly   116 LLEHGRRITDNRVWRVELRVRYVPNNIQELFEEDKATCFYYFNQVKEDFIQANVTAIDTEVAVQL 180
                         ||.:||:||:|.:..|.|::||.|..|::.|::.|::|...|.:...:|:||
Frog   123 -------------WRYDLRIRYLPEDFNESFKKDKTTLLYFYQQLRNDYMQQYATKVSEGMALQL 174

  Fly   181 CCLGIRHYFKNITVKAPDKKQHIDYIEKEIGFKSFLPQSVIATSKPKNLKKLIQVGYKKVYNYND 245
            .||.:|.::|::...|.:||.:.:::|||:|...|.|:.:..:.|||..:|:||..:::..:..:
Frog   175 GCLELRRFYKDMPQNALEKKSNFEFLEKEVGLDLFFPKQMQESLKPKQFRKMIQQTFQQYGSLKE 239

  Fly   246 IEYLTRFFDLLKNIYLTNFEQFSVTLSSAWNISGILHVGPHIGISYQTHPQASLKNVAQFKDVVS 310
            .|.:|||.:.|......:.|.:...|:..|:|:..|.:||. ||...|...:.....|:||.:.|
Frog   240 EECITRFMNTLSTFTSIDQETYRCELAQGWSITVDLVIGPK-GIRQLTTKDSKPTCFAEFKQIKS 303

  Fly   311 IKTCTLPKEKLSKSGENTTEPELQNFNCNCQKIKTQIKISASNNVEDLVITCNGINTAESIADLI 375
            || |:|.::..:                       .:.:..|...:.|.|..:.:..||::||||
Frog   304 IK-CSLLEDGWA-----------------------LLLLGISGAPQPLAIKTSSLAVAENMADLI 344

  Fly   376 DGYCRLLSKDLEFTIWHRETNASNEDSAKALPNDATLGSNKSTSSQGKPMLTDDYAEIGLLEGEG 440
            ||||||.::..:..|.:.:.:.....|...:|.: .:...:|...:|..|.:|.||||    .|.
Frog   345 DGYCRLQNESKDSLIVNPKKDNEKRISLPQIPTE-EVQVRRSRLVEGNSMESDIYAEI----PEV 404

  Fly   441 DYSTPTVRNYELDRALITPSAKIGVGQFGDVYVGTYTLPKLGKGKNLAGNGKNSNSDQRNADSRP 505
            ..:..|...:.:.|:.:.....:|.|.||:||.|.|..||                        .
Frog   405 TETKLTNNRFTISRSDVALGRILGEGFFGEVYDGVYVKPK------------------------G 445

  Fly   506 DVIQVAIKTCKANDDPEKTENFLAEAYIMQKFDHPHIIRLIGICSVMPIWIVMELAKLGELRAYL 570
            |.|.||:||||.:...:..|.|::|||:|:..|||||::||||....||||||||...|||..||
Frog   446 DKINVAVKTCKNDCAADVKEKFMSEAYLMRNLDHPHIVKLIGIIEDDPIWIVMELYPYGELGQYL 510

  Fly   571 KTNSERLSHGTLLKYCYQLSTALSYLESKKFVHRDIAARNVLVSSPTCVKLADFGLSRWVSDQSY 635
            :.|...|...:|:.|..|:..||:|||....||||||.||:||:||.||||.||||||::.::.|
Frog   511 EKNKNSLQVLSLILYSLQICKALAYLEGINCVHRDIAVRNILVASPECVKLGDFGLSRYLEEEEY 575

  Fly   636 YHSTPTVALPIKWMSPESINFRRFTTASDVWMFGVCIWEILMLGVKPFQGVKNSDVILKLENGER 700
            |.::.| .||||||:||||||||||:||||||||||:||||..|.:||..::|.|||..:|.|:|
Frog   576 YKASVT-RLPIKWMAPESINFRRFTSASDVWMFGVCMWEILSFGKQPFFWLENKDVISVIEKGDR 639

  Fly   701 LPLPPNCPPRLYSLMSQCWAYEPLKRPNFKRIKETLHEIL-IEDSINSSETLKREQR--KVASMS 762
            ||.|..|||.||:||::||.|:|.:||.|..:..:|.:|. .|..|...:.....||  |:
Frog   640 LPKPEMCPPTLYTLMTRCWTYDPFERPKFTELVCSLSDIYQTEKEIIKDKERNNRQRPPKI---- 700

  Fly   763 WIGSDDIDIPPSKPSRVMHDPDITGLMPETTGLPQTYIIAQNPAVLAKLMMENQKRGINPAAYTT 827
             |....:..||.||||..:.....|
Frog   701 -IEPPPMQEPPPKPSRPKYKAAAPG---------------------------------------- 724

  Fly   828 PASVFNTLAVGLDDSNPNVSLKTTKLPAADLLKLDPIAESERLRSQFSANSSASQLANPLTASVN 892
                 |.||       ||:   .|::|
Frog   725 -----NLLA-------PNL---LTQVP-------------------------------------- 736

  Fly   893 PHESLNSHQAGMFTGSLPSKSSFVVCPPQTEEHMQAENISNPSVSKVSGYSLYGSLERHQPPPAK 957
              |||                    |            .|:|::...:.|.  ..|:..:.||
Frog   737 --ESL--------------------C------------ASSPTLCSPTDYQ--SPLDSTRSPP-- 763

  Fly   958 AMHSKGGSLERHQSLMSAQNLVFYNTKPPPNCTNTAERSRSMERNTYFHAYRQQMKTSIECEALP 1022
                    |.||.        :|              :.|||.
Frog   764 --------LPRHS--------IF--------------KRRSMR---------------------- 776

  Fly  1023 EEIYDFGGIGLKTCVSARQQPKFSPMVNVRPAELGQVQNTDCMGLQQNIPMDSFGVISPHNLDES 1087
            ||  ||                      |:|                             |..|.
Frog   777 EE--DF----------------------VKP-----------------------------NSKEE 788

  Fly  1088 LRHQREMERQWMTSGPQSITVNPNISISEGAACLATLQAEAMGNQGIHNVLGEKLRQQQKDSNSD 1152
            .:...|.||..|                        ||.               |.:||:....|
Frog   789 AQKLWEKERDKM------------------------LQV---------------LNRQQQQMEED 814

  Fly  1153 SEWLIQEE--LLRSCSIPQGSLNDH-------QAQMFKLDFMSAGPSSLPDCSNSSSRPM--TPN 1206
            .:||.|||  |..:....:...|::       :.::...:| :..|...|.....|.:|:  ||.
Frog   815 GKWLKQEEKSLANTLKDSKQKTNNNKPPDALPEKELAYTEF-TVPPQKPPRLGAQSLQPLQPTPT 878

  Fly  1207 ANLSSLKSNHSSADHLSSLTSAEEQMGSNARNLGSAVPSRPPNRADDEVYCATTLVVKSIMALSQ 1271
            ||:                                       :|.||.||.:...:||:::.|..
Frog   879 ANI---------------------------------------DRTDDGVYQSVMELVKAVLQLKN 904

  Fly  1272 GVEKANTEGYLELVKNVGVKLRNLLTSVDKISIIFPAQALKEVQMAHQVLSKDMHELVSAMRLAQ 1336
            .:.:...|||:.:|||||:.||.|:.|||:|....|..:..|::...::||||:.||::.|||||
Frog   905 DIYQLPPEGYVAVVKNVGLTLRKLIGSVDEILPSLPQNSRTEIEGTQKLLSKDLAELINKMRLAQ 969

  Fly  1337 QYSDTTLDCEYRKSMLSAAHVLAMDAKNLFDVVDSIRQR 1375
            |.:.|:|..|.:|.||:|:|.:|:|||||.|.||..|.|
Frog   970 QNAVTSLSEECKKQMLTASHTMAVDAKNLLDAVDQARVR 1008

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fak	NP_001137718.1	B41	24..267	CDD:214604	66/253 (26%)
		FERM_B-lobe	152..257	CDD:271216	32/104 (31%)
		FERM_C_FAK1	263..394	CDD:270011	34/130 (26%)
		PTKc_FAK	450..744	CDD:133187	142/294 (48%)
		Pkinase_Tyr	462..736	CDD:285015	138/273 (51%)
		Focal_AT	1249..1376	CDD:281606	56/127 (44%)
ptk2b	XP_012819490.1	FERM_N_2	35..133	CDD:407875	27/126 (21%)
		B41	37..261	CDD:214604	65/252 (26%)
		FERM_C_FAK1	257..364	CDD:270011	34/131 (26%)
		PTKc_FAK	414..683	CDD:133187	141/293 (48%)
		Focal_AT	880..1009	CDD:397606	57/168 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	324	1.000	Domainoid score	I1200
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	633	1.000	Inparanoid score	I826
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D29350at33208
OrthoFinder	1	1.000	-	-		FOG0002650
OrthoInspector	1	1.000	-	-		otm49324
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4950
SonicParanoid	1	1.000	-	-		X1755
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.000