DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fak and Abl

DIOPT Version :9

Sequence 1:	NP_001137718.1	Gene:	Fak / 37233	FlyBaseID:	FBgn0020440	Length:	1500	Species:	Drosophila melanogaster
Sequence 2:	NP_001261962.1	Gene:	Abl / 45821	FlyBaseID:	FBgn0000017	Length:	1723	Species:	Drosophila melanogaster

Alignment Length:	1501	Identity:	322/1501 - (21%)
Similarity:	513/1501 - (34%)	Gaps:	472/1501 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   318 KEKLSKSGENTTEPE----LQNFNCNCQ-----KIKTQIKI-------------SASNNV----E 356
            ||.|...|....:|:    |.:|....:     |...|::|             |.|.||    .
  Fly   194 KENLLAPGPEEDDPQLFVALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEAHSDSGNVGWVPS 258

  Fly   357 DLVITCNGI------------NTAESIADLIDGYCRLLSKDLEFTIWHRETNASNEDSAKALPND 409
            :.|...|.:            |.||          .|||..:..:...||:.:|....:.:|..:
  Fly   259 NYVTPLNSLEKHSWYHGPISRNAAE----------YLLSSGINGSFLVRESESSPGQRSISLRYE 313

  Fly   410 ATLGSNK-STSSQGKPMLTDDYAEIGLL-----------EGEG----------DYSTPTV----- 447
            ..:...: |....||..:|.: |:...|           ||.|          ..:.|||
  Fly   314 GRVYHYRISEDPDGKVFVTQE-AKFNTLAELVHHHSVPHEGHGLITPLLYPAPKQNKPTVFPLSP 377

  Fly   448 --RNYELDRALITPSAKIGVGQFGDVYVGTYTLPKLGKGKNLAGNGKNSNSDQRNADSRPDVIQV 510
              ..:|:.|..|....|:|.||:|:||...:         ...||                  .|
  Fly   378 EPDEWEICRTDIMMKHKLGGGQYGEVYEAVW---------KRYGN------------------TV 415

  Fly   511 AIKTCKANDDPEKTENFLAEAYIMQKFDHPHIIRLIGICS-VMPIWIVMELAKLGELRAYLKT-N 573
            |:||.|  :|....::||.||.||::..||::::|||:|: ..|.:|:.|....|.|..:|:: .
  Fly   416 AVKTLK--EDTMALKDFLEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAG 478

  Fly   574 SERLSHGTLLKYCYQLSTALSYLESKKFVHRDIAARNVLVSSPTCVKLADFGLSRWVSDQSY-YH 637
            .|.|....||....|:::.:|||||:.::|||:||||.||.....||:|||||:|.:.|.:| .|
  Fly   479 RETLDAVALLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLMRDDTYTAH 543

  Fly   638 STPTVALPIKWMSPESINFRRFTTASDVWMFGVCIWEILMLGVKPFQGVKNSDVILKLENGERLP 702
            :  ....||||.:||.:.:.:|:|.||||.|||.:|||...|:.|:..:..:||..||:.|.|:.
  Fly   544 A--GAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYPAIDLTDVYHKLDKGYRME 606

  Fly   703 LPPNCPPRLYSLMSQCWAYEPLKRPNFKRIKETLHEILIEDSINSSETLKRE--------QRKVA 759
            .||.|||.:|.||.|||.::...||.||.|...|..:..|.||  :|.::::        .....
  Fly   607 RPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHALEHMFQESSI--TEAVEKQLNANATSASSSAP 669

  Fly   760 SMSWIGSDDIDIPPSKPSRVMHDPDIT---GLMPETT--GLPQTYIIAQNPAVLAKLMMENQKRG 819
            |.|.:.:.......:..|........|   .|.|:..  |||....:..|    |.....:|::.
  Fly   670 STSGVATGGGATTTTAASGCASSSSATASLSLTPQMVKKGLPGGQALTPN----AHHNDPHQQQA 730

  Fly   820 INPAAYT----TPASVFNTLAVGLDDSNPNVSLKTT------KLPAADLLKLDPIAESER---LR 871
            ..|.:.|    |..|.|::...|      ||.::.|      :.||..  |...:..|.|   .|
  Fly   731 STPMSETGSTSTKLSTFSSQGKG------NVQMRRTTNKQGKQAPAPP--KRTSLLSSSRDSTYR 787

  Fly   872 SQFSANSSASQLANPLTASVNPHESLN------------------SH----QAGMFTGSLPSKSS 914
            .:..||:..:.:.:..|..::..::.|                  :|    |......|:..:..
  Fly   788 EEDPANARCNFIDDLSTNGIHKLKTANYFSQTLSRNFKTQIPTHHTHQIRTQQQQQQQSVQQQQQ 852

  Fly   915 FVVCPPQTEEHMQAENISNPSVSKVSGYS--LYGSLER--------------HQPPPA------- 956
            .|....|.:.|.|.:.....|:.|.|..|  ||..|.|              .:..||
  Fly   853 IVPLSVQQQAHQQQQKQQQYSIKKSSSCSSFLYDILFRGLARDINSLTQRYDSETDPAADPDTDA 917

  Fly   957 ----------------------KAMHSKGG-------SLERHQS--------LMSAQNLVFYNTK 984
                                  .::||.||       |.::|.|        :|..:.|....:|
  Fly   918 TGDSLEQSLSQVIAAPVTNKMQHSLHSGGGGGGIGPRSSQQHSSFKRPTGTPVMGNRGLETRQSK 982

  Fly   985 ------------PPP-------------------------NCTNTAERSRSMERNTYFHAYRQQM 1012
                        ||.                         |......|..::.:.....||...:
  Fly   983 RSQLHSQAPGPGPPSTQPHHGNNGVVTSAHPITVGALDVMNVKQVVNRYGTLPKGARIGAYLDSL 1047

  Fly  1013 KTSIE-CEALPEEIYDF-GGIGLKTCVSARQQPKFSPMVNVRPAELGQVQNTDCMGLQQNIPMDS 1075
            :.|.| ..|||...... ...|..|..:||..||.||   :.|              ||.|..:|
  Fly  1048 EDSSEAAPALPATAPSLPPANGHATPPAARLNPKASP---IPP--------------QQMIRSNS 1095

  Fly  1076 FGVISPHN-----LDESLRHQREMERQWMT---------------------SGPQSITVN----- 1109
            .|.::..|     |::..||:...|...||                     ||.|....|
  Fly  1096 SGGVTMQNNAAASLNKLQRHRTTTEGTMMTFSSFRAGGSSSSPKRSASGVASGVQPALANLEFPP 1160

  Fly  1110 PNISIS------EGA-------------ACLATLQAEAMGNQGIHNVLGEKLRQQQKDSNSDSEW 1155
            |.:.:.      ||.             |....|.|:...|..|.|..|........:..|:...
  Fly  1161 PPLDLPPPPEEFEGGPPPPPPAPESAVQAIQQHLHAQLPNNGNISNGNGTNNNDSSHNDVSNIAP 1225

  Fly  1156 LIQEELLR-------------SCSIPQGSLNDHQAQMFKLDFMSAGPSSLP-------------- 1193
            .::|...|             ||| ..||..:...:....:..:||..:.|
  Fly  1226 SVEEASSRFGVSLRKREPSTDSCS-SLGSPPEDLKEKLITEIKAAGKDTAPASHLANGSGIAVVD 1289

  Fly  1194 -------DCSNSSSRPMTPNANLSSLKSNHSSADHLSSLTSAEEQMGSNARNLGSAVPSRPP--- 1248
                   :.:.|.:.|..|......|.:.:|:.....:.....|     .:.:.:.:|...|
  Fly  1290 PVSLLVTELAESMNLPKPPPQQQQKLTNGNSTGSGFKAQLKKVE-----PKKMSAPMPKAEPANT 1349

  Fly  1249 --------NRADDEVYCATTLVVKSIMALSQGVEKANTEGYLELVKNVGVKLRNLLTSVDKISII 1305
                    .|.|.|...||.....:.:|::... ..||.|.|...::...|.
  Fly  1350 IIDFKAHLRRVDKEKEPATPAPAPATVAVANNA-NCNTTGTLNRKEDGSKKF------------- 1400

  Fly  1306 FPAQALKEVQMAHQVLSKDMH------------------ELVSAMRLAQQ------YSDTTLDCE 1346
              :||:::.::...|.:.::.                  .:.|..:|.:|      |:.:|: .:
  Fly  1401 --SQAMQKTEIKIDVTNSNVEADAGAAGEGDLGKRRSTGSINSLKKLWEQQPPAPDYATSTI-LQ 1462

  Fly  1347 YRKSM----------LSAAHVLAMDAKNLFDVVDSIRQRYQHLFPPSA--------TKETSCSSS 1393
            .:.|:          ||..:.:...|.|   .|.::..:..:..||:|        |...|.::|
  Fly  1463 QQPSVVNGGGTPNAQLSPKYGMKSGAIN---TVGTLPAKLGNKQPPAAPPPPPPNCTTSNSSTTS 1524

  Fly  1394 FESTSGSIVAEPVNDLGGYIKTSTSGDLLQNTGIYDNDLHHSFNSQLQLQNPKASIDLSGG-GSL 1457
            ..::|....:.  ......||||.|      |.::.:|...|....|.          ||| ||.
  Fly  1525 ISTSSRDCTSR--QQASSTIKTSHS------TQLFTDDEEQSHTEGLG----------SGGQGSA 1571

  Fly  1458 QRGMSL 1463
            ....||
  Fly  1572 DMTQSL 1577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fak	NP_001137718.1	B41	24..267	CDD:214604
		FERM_B-lobe	152..257	CDD:271216
		FERM_C_FAK1	263..394	CDD:270011	22/113 (19%)
		PTKc_FAK	450..744	CDD:133187	110/296 (37%)
		Pkinase_Tyr	462..736	CDD:285015	105/276 (38%)
		Focal_AT	1249..1376	CDD:281606	25/160 (16%)
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784	10/53 (19%)
		SH2_ABL	268..363	CDD:198189	19/105 (18%)
		PTKc_Abl	382..644	CDD:270645	109/292 (37%)
		Pkinase_Tyr	389..640	CDD:285015	106/281 (38%)
		FABD	1584..1723	CDD:197885
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468395
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840