Protein Alignment Fak and Shark

DIOPT Version :10

• Sequence 1: NP_001137718.1
• Gene: Fak / 37233
• FlyBaseID: FBgn0020440
• Length: 1500
• Species: Drosophila melanogaster
• Sequence 2: NP_524743.2
• Gene: Shark / 44353
• FlyBaseID: FBgn0015295
• Length: 939
• Species: Drosophila melanogaster
• Alignment Length: 916
• Identity: 217/916 - (23%)
• Similarity: 329/916 - (35%)
• Gaps: 299/916 - (32%)

  Fly    11 PPTKNEINSEEYLIHVHMPNKSFKAVRFNVKETVFHVIR---RTVEDLGTDGRTPSIQRYACRML 72
            ||.....:....|:|        :|...|..:.||.:::   |..:....||:|
  Fly   111 PPHNTRSHGVTNLLH--------RATSKNESKVVFELLKCGYRNFDAKNQDGQT----------- 156

  Fly    73 NMITKEVIWLARSTSMQKVLSHILTP----------GCS--NVDCPNNQSELDEVLLE-----HG 120
                  .:.||...|.:.:|.|:|..          ||.  :....:..:.....|:.     .|
  Fly   157 ------ALHLAALHSDEDILKHLLNAKVQVNSSDSFGCQPLHYAARSKPASFIRTLISAQANVQG 215

  Fly   121 RRITDNRVWRVELRVRYVP----------NNIQELFEED------KATCFYYFNQVK-------E 162
            |.| ||         .|||          ..:|||...:      .::..:.|:..|       |
  Fly   216 RNI-DN---------GYVPLHEAAKHGNLEAVQELLLAEAPPLPRTSSGEFPFDLAKEAGQTAVE 270

  Fly   163 DFI------QANVT-------AIDTEVAVQLCCLGIRHYFKNITVKAPDKKQH----IDYIEKEI 210
            :|:      .||.|       .:..|.||.:    ::.:.|.:..|.|:....    :.|.|...
  Fly   271 EFLLNYKLPPANTTRDQWYHGTLTREEAVAI----LKKHAKELLAKQPEVDTSGCFLVRYSESPA 331

  Fly   211 GFKSFLPQSVIATSKPKNLK----------KLIQVGYKKVYNYND------IEYLTRFFDLLKNI 259
            .  |.|..:::.....||.:          ..:|.|..|....:|      :|:|
  Fly   332 A--SGLVLTLLCDQVVKNFRISQADLYQNGNKVQSGGSKFLYIDDGPYWPSVEHL---------- 384

  Fly   260 YLTNFEQFSVTL-----------------------------SSAWNISGILHVGPHIGISYQTHP 295
             :.:|.:||..|                             .:|...:....|.||   |:..||
  Fly   385 -IAHFMRFSYGLPVSLKYPVPPQPKPEVPSFATIPRSNMKPKAASPATPPTPVSPH---SHHQHP 445

  Fly   296 QASLKNVAQFK------DVVSIKTCTLPKEKL--------------------SKSGENT-TEPEL 333
            ......:.:.|      .:.:....|.||:.|                    |.||... ||.||
  Fly   446 HVPALTITKKKQKENSSSMFNTLRLTSPKKALFDMNSLRKNKSKGKRSDSESSVSGSLAGTEQEL 510

  Fly   334 Q----------------NFNC---------------NCQKIKTQIKI-------SASNNVE---- 356
            |                .||.               |..:..|.|:|       .....||
  Fly   511 QAAAPMLKSLSFSTEFSTFNADGVTGSGAAAAGEVYNVPRNNTPIEIDLPPIAQKTEAEVEYFTK 575

  Fly   357 -DLVI--------TCNGINTAESIADLIDGYCRLLSKDLEFTIWHRETNASNEDSAKALPNDATL 412
             |:.|        ..||......:..|:|                      .:..|.|:....:|
  Fly   576 SDVAIERERAGQWIGNGYQPTMDVLSLLD----------------------QQIKAPAVARLNSL 618

  Fly   413 GSNKSTSSQGKPMLTDDYAEIGLLEGEGDYSTPTVRNYELD--RALITP-----SAKIGVGQFGD 470
            |.|.||.|:....|.        .:..|..|||:....|..  |..|.|     ..:||.|:||.
  Fly   619 GPNASTESEMASYLH--------RKCSGTPSTPSATEVEAAKLRFFIEPEKLVLDREIGHGEFGS 675

  Fly   471 VYVGTYTLPKLGKGKNLAGNGKNSNSDQRNADSRPDVIQVAIKTCKANDDPEKTENFLAEAYIMQ 535
            |:.| :.|.|.|.|:                :||   ::||||  ..:|:....:.||.||.:|.
  Fly   676 VHSG-WLLRKSGAGE----------------ESR---LEVAIK--MLSDEHSNKQEFLREASVMM 718

  Fly   536 KFDHPHIIRLIGICSVMPIWIVMELAKLGELRAYLKTNSERLSHGTLLK-YCYQLSTALSYLESK 599
            :.:|..|:|||||.....:.:|.|||.||.:..|:..:...::....|| :..|::..:.||||:
  Fly   719 RLEHKCIVRLIGIAKGEMLMMVQELAPLGSMLQYILDHGHEITANAELKVWASQIACGMHYLESQ 783

  Fly   600 KFVHRDIAARNVLVSSPTCVKLADFGLSRWVSDQS-YYHSTPTVALPIKWMSPESINFRRFTTAS 663
            .|||||:||||:|:::....|::|||:||.:...| .|..|.....||:|.:|||.|...|:.||
  Fly   784 HFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFTQGGRWPIRWYAPESFNLGIFSHAS 848

  Fly   664 DVWMFGVCIWEILMLGVKPFQGVKNSDVILKLENGERLPLPPNCPPRLYSLMSQCWAYEPLKRPN 728
            |||.|||.|||:..||..|:..:.|.|.|..:::|||||.|..||..:|::|..||...|..||.
  Fly   849 DVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERLPQPNLCPAYIYAVMQSCWKERPKDRPT 913

  Fly   729 FKRIKE 734
            |..:.|
  Fly   914 FVYLTE 919

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fak	NP_001137718.1	B41	24..267	CDD:214604	55/318 (17%)
		FERM_B-lobe	152..257	CDD:271216	25/144 (17%)
		FERM_C_FAK1	263..394	CDD:270011	38/237 (16%)
		PTKc_FAK	450..744	CDD:133187	109/294 (37%)
		Focal_AT	1250..1376	CDD:460992
Shark	NP_524743.2	SH2_Nterm_shark_like	8..91	CDD:198210
		ANKYR	<94..317	CDD:440430	45/244 (18%)
		ANK repeat	124..151	CDD:293786	6/34 (18%)
		ANK repeat	153..184	CDD:293786	9/47 (19%)
		ANK repeat	186..217	CDD:293786	4/30 (13%)
		ANK repeat	220..245	CDD:293786	7/33 (21%)
		SH2_Cterm_shark_like	287..395	CDD:198211	21/124 (17%)
		PTKc_Syk_like	666..926	CDD:270650	105/276 (38%)