Protein Alignment Fak and lck

DIOPT Version :10

• Sequence 1: NP_001137718.1
• Gene: Fak / 37233
• FlyBaseID: FBgn0020440
• Length: 1500
• Species: Drosophila melanogaster
• Sequence 2: NP_001001596.1
• Gene: lck / 414333
• ZFINID: ZDB-GENE-040617-1
• Length: 503
• Species: Danio rerio
• Alignment Length: 461
• Identity: 135/461 - (29%)
• Similarity: 209/461 - (45%)
• Gaps: 84/461 - (18%)

  Fly   316 LPKEKLSKSGENTTEPELQNFNCNCQKIKTQIKISASNNVEDLVITCNGINTAE--------SIA 372
            :||..::|.....|||.   |..|..:.....::.|..|.:...:    |..:|        |:.
Zfish   104 IPKNFVAKLNSMETEPW---FYKNLSRNDAMRQLLAPGNTQGSFL----IRESETQPGSFSISVR 161

  Fly   373 DL------IDGYCRLLSKDL-EFTIWHRETNASNEDSAKALPNDA-----TLGSNKSTSSQGKPM 425
            ||      |..:.|:.:.|. .|.|.::.:..|..:..|....:|     .|.....|.:..||.
Zfish   162 DLDPMQGDIIKHYRIRNMDAGGFYITNKISFNSLSELVKHYSREADGLCTRLVKPCQTRAPQKPW 226

  Fly   426 LTDDYAEIGLLEGEGDYSTPTVRNYELDRALITPSAKIGVGQFGDVYVGTYTLPKLGKGKNLAGN 490
            ..|:                    :|:.|..:....::|.||||:|::|.|
Zfish   227 WQDE--------------------WEVPRESLKLERRLGQGQFGEVWMGLY-------------- 257

  Fly   491 GKNSNSDQRNADSRPDVIQVAIKTCKANDDPEKTENFLAEAYIMQKFDHPHIIRLIGICSVMPIW 555
              |:|.            |||||:.|..  ......|||||.:|:...||.::||..:.:..||:
Zfish   258 --NNNR------------QVAIKSLKPG--TMSISAFLAEANLMKSLQHPRLVRLFAVVTQEPIY 306

  Fly   556 IVMELAKLGELRAYLKT-NSERLSHGTLLKYCYQLSTALSYLESKKFVHRDIAARNVLVSSPTCV 619
            |:.|..:.|.|..:||| ....:...||:....|::..::|:|.|.::|||:.|.|:|||.....
Zfish   307 IITEYMENGSLVDFLKTPEGSDIPINTLIDMAAQVAEGMAYVEQKNYIHRDLRAANILVSHELTC 371

  Fly   620 KLADFGLSRWVSDQSYYHSTPTVALPIKWMSPESINFRRFTTASDVWMFGVCIWEILMLGVKPFQ 684
            |:|||||:|.:.:.. |.:......||||.:||:||:..|:..||||.|||.:.||:..|..|:.
Zfish   372 KIADFGLARLIKNNE-YTAREGAKFPIKWTAPEAINYGTFSIKSDVWSFGVLLTEIVTYGRIPYP 435

  Fly   685 GVKNSDVILKLENGERLPLPPNCPPRLYSLMSQCWAYEPLKRPNFKRIKETLHEILIEDSINSSE 749
            |:.|.:||..||.|.|:|.|.|||..||::|..||...|..||.|:.::..|     ||...::|
Zfish   436 GMTNPEVIANLERGYRMPCPDNCPEALYNVMKHCWTENPDNRPTFEFLRSVL-----EDFFTATE 495

  Fly   750 TLKREQ 755
            ...:||
Zfish   496 GQYQEQ 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fak	NP_001137718.1	B41	24..267	CDD:214604
		FERM_B-lobe	152..257	CDD:271216
		FERM_C_FAK1	263..394	CDD:270011	20/92 (22%)
		PTKc_FAK	450..744	CDD:133187	103/294 (35%)
		Focal_AT	1250..1376	CDD:460992
lck	NP_001001596.1	SH3_Lck	57..111	CDD:212938	2/6 (33%)
		SH2_Src_Lck	116..216	CDD:198225	21/106 (20%)
		PTKc_Lck_Blk	230..493	CDD:270652	104/318 (33%)