DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fak and Csk

DIOPT Version :9

Sequence 1:	NP_001137718.1	Gene:	Fak / 37233	FlyBaseID:	FBgn0020440	Length:	1500	Species:	Drosophila melanogaster
Sequence 2:	NP_001262476.1	Gene:	Csk / 41398	FlyBaseID:	FBgn0262081	Length:	1052	Species:	Drosophila melanogaster

Alignment Length:	534	Identity:	142/534 - (26%)
Similarity:	219/534 - (41%)	Gaps:	138/534 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   268 SVTLSSAWNISG-ILHVGPHIGISYQTHPQASLKNVAQFKDVVSIKTCTLPKEKLSKSGENTTEP 331
            |:.||.:.:.|. :||..|.       .||||     |...||.:          |.||......
  Fly   584 SLALSGSQHGSNMLLHTAPQ-------PPQAS-----QPAAVVGV----------SGSGSAGMST 626

  Fly   332 ELQNFNCNCQKIKTQIKISASNNVEDLVITCNGINTAESIADLI-------DGYCR--------- 380
            .|.:|:.|        .::|.:.|.......:|..||.:.|.|.       .|..|
  Fly   627 SLHSFDIN--------GVTAGSGVNASSAWSSGSTTAMNHASLSPTALAPQQGRSRCEVKLNAMP 683

  Fly   381 -----LLSKDLEFTIWHRETNASNEDSAKALPNDATLG---------------SNKSTSSQGKPM 425
                 :...:.|..:..||........:...|.|.||.               .||.|...
  Fly   684 WFHGSITRDEAEHLLQPREDGLFLVRESTNFPGDYTLCVCFQSKVEHYRVKYLENKLTIDD---- 744

  Fly   426 LTDDYAE-IGLL----EGEGD-------YSTPTVRNYE--------LDRALITPSAK------IG 464
              ::|.| :|.|    |.:.|       ...|.:...|        :|:..:.|.|:      ||
  Fly   745 --EEYFENLGQLVAHYEADADGLCTQLIKCLPKLGKQEFCINSKDFVDKGWVIPEAELQLRESIG 807

  Fly   465 VGQFGDVYVGTYTLPKLGKGKNLAGNGKNSNSDQRNADSRPDVIQVAIKTCKANDDPEKTENFLA 529
            .|:||||.:|..                      ||.       :||:|..|   |....:.|||
  Fly   808 KGEFGDVMLGIL----------------------RNE-------KVAVKMLK---DEGAVQKFLA 840

  Fly   530 EAYIMQKFDHPHIIRLIG-ICSVMPIWIVMELAKLGELRAYLKTNS-ERLSHGTLLKYCYQLSTA 592
            ||.:|...:|.::::.|| :.:...:::|.|....|.|..||::.. :.::....:.:.|..::.
  Fly   841 EASVMTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQIIFAYDTASG 905

  Fly   593 LSYLESKKFVHRDIAARNVLVSSPTCVKLADFGLSRWVSDQSYYHSTPTVALPIKWMSPESINFR 657
            :.|||:||.||||:||||||:|.....|::||||:|   ::.|  :.....|||||.:||::...
  Fly   906 MEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGLAR---EECY--NLDVGKLPIKWTAPEALKNG 965

  Fly   658 RFTTASDVWMFGVCIWEILMLGVKPFQGVKNSDVILKLENGERLPLPPNCPPRLYSLMSQCWAYE 722
            ||:..||:|.||:.:|||...|..|:..:..:||:..:|.|.::..|..|||.:|.:|.|.|...
  Fly   966 RFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLN 1030

  Fly   723 PLKRPNFKRIKETL 736
            |.|||.|..:|..|
  Fly  1031 PAKRPTFAELKVKL 1044

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fak	NP_001137718.1	B41	24..267	CDD:214604
		FERM_B-lobe	152..257	CDD:271216
		FERM_C_FAK1	263..394	CDD:270011	30/147 (20%)
		PTKc_FAK	450..744	CDD:133187	96/303 (32%)
		Pkinase_Tyr	462..736	CDD:285015	91/281 (32%)
		Focal_AT	1249..1376	CDD:281606
Csk	NP_001262476.1	SH2_csk_like	680..777	CDD:198190	17/102 (17%)
		PTKc_Csk_like	793..1047	CDD:270635	94/289 (33%)
		STYKc	800..1044	CDD:214568	91/280 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468358
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840