DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fak and FER

DIOPT Version :9

Sequence 1:	NP_001137718.1	Gene:	Fak / 37233	FlyBaseID:	FBgn0020440	Length:	1500	Species:	Drosophila melanogaster
Sequence 2:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster

Alignment Length:	897	Identity:	200/897 - (22%)
Similarity:	328/897 - (36%)	Gaps:	289/897 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 HVIRRTV------EDLGTDGRTP----SIQRYACRMLNM-ITKEVIWLARSTSMQKVLSHILTPG 99
            |.:|:..      |::.|....|    .::|..|.||.: ..:|.:.||....:.::.:.:||..
  Fly   511 HRLRQAASVHYLGEEIATSSTNPPDLTRLRRTQCSMLCLGEDEEPVVLASPAPLTQLTAAVLTNT 575

  Fly   100 CSN-------VDCPNNQSELDEVLLEHGRRITDNRVW-RVELRVRYVPNN--------IQELFEE 148
            .:|       :|...:.|...|.   .|.:|...:.. |:|:. :..|.|        |.||
  Fly   576 NNNHIYADLELDKKKDTSPSPEC---KGEQIQPKKEQIRIEIN-QTAPQNSIDAHLDRIDEL--- 633

  Fly   149 DKATCFYYFNQVKEDFIQANVTAIDTEVAVQLCCLGIRHYFKNITVKAPD--------------- 198
                     |:|.:|.::..:...|...|::  .....|.......|.||
  Fly   634 ---------NRVLDDRLKRTLQPSDDVNAIE--SAEENHIQTRKLAKDPDSQTKRSSSSSSECRS 687

  Fly   199 -------KKQHIDYIEKEIGFKSFLPQSVIATSKPKNLKKLIQVGYKKVYNYNDIEYLTRFFDLL 256
                   ||:.:.:.:|.|       .::.:..|..:...|:::|
  Fly   688 SKDTSHSKKRSLSFSQKSI-------SNIFSNLKEFSKSPLVRMG-------------------- 725

  Fly   257 KNIYLTNFEQFSVTLSSAWNISGILHVGPHIGISYQTHPQASLKN---------------VAQFK 306
            ||..|...:....|..|..:.|.        |....|:..:|..|               .:|..
  Fly   726 KNHILNEEQDAKRTQPSQHHHSS--------GSDCPTNSSSSSSNNNNNNKNTSSNSNHSASQST 782

  Fly   307 DVVSIKTCTL-------------------PK-EKLSKSGENTTEPELQNFNCN----CQKIKTQI 347
            .:.|..|.|:                   || :|.||:..||...:|.||...    |::...:.
  Fly   783 IITSTITTTITTTTTTTPSKENSRLKFKVPKIQKKSKAIRNTFRSKLLNFQLKRSKPCKQCTKRR 847

  Fly   348 KISASNNVEDLVITCNGINTAESIADLIDGYCRL-------------LS--KDLEFTIWHRETNA 397
            :|..|.:|.|..........|.|.||  :.:|..             :|  ||..|   ...:..
  Fly   848 RIHPSKSVFDFAKEFEVEQPAGSAAD--EQFCNCPPAGQKPVKPSVQISGHKDHPF---ESSSGE 907

  Fly   398 SNEDSAKALPND---------------------ATLGSNKSTSSQGKPMLTDDYAE--------I 433
            .:|:|.:.:.||                     .:|.::.|.|: .:|:..:::..        :
  Fly   908 LDENSDRDIDNDEEEEDSASDDVLSMKDHCYCVPSLAASISLST-NRPLYEEEWFHGVLPREEVV 971

  Fly   434 GLLEGEGDYST-PTVRN------------------------------------------------ 449
            .||..:||:.. .|:||
  Fly   972 RLLNNDGDFLVRETIRNEESQIVLSVCWNGHKHFIVQTTGEGNFRFEGPPFASIQELIMHQYHSE 1036

  Fly   450 -------------------YELDRALITPSAKIGVGQFGDVYVGTYTLPKLGKGKNLAGNGKNSN 495
                               :||....:....:||.|.|||||
  Fly  1037 LPVTVKSGAILRRPVCRERWELSNDDVVLLERIGRGNFGDVY----------------------- 1078

  Fly   496 SDQRNADSRPDVIQVAIKTCKANDDPEKTENFLAEAYIMQKFDHPHIIRLIGIC-SVMPIWIVME 559
                .|..:...:.||:|||:.....|:...||.|..|::::|||:|::||||| ...||.||||
  Fly  1079 ----KAKLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVME 1139

  Fly   560 LAKLGELRAYLKTNSERLSHGTLLKYCYQLSTALSYLESKKFVHRDIAARNVLVSSPTCVKLADF 624
            |...|.|..||:.||..|:....:..|...:..:.|||||..:|||:||||.||.....||::||
  Fly  1140 LVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDF 1204

  Fly   625 GLSRWVSDQSYYHSTPTVALPIKWMSPESINFRRFTTASDVWMFGVCIWEILMLGVKPFQGVKNS 689
            |:||  .::.|..|.....:|:||.:||::||.::|:..|||.:|:.:|||...|..|:.|:.||
  Fly  1205 GMSR--EEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNS 1267

  Fly   690 DVILKLENGERLPLPPNCPPRLYSLMSQCWAYEPLKRPNFKRIKETLHEILI 741
            ....:::.|.|:|.|.:.|..:|.||.||||.:...||:|..|...:..:::
  Fly  1268 RARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVVDALIL 1319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fak	NP_001137718.1	B41	24..267	CDD:214604	46/269 (17%)
		FERM_B-lobe	152..257	CDD:271216	16/126 (13%)
		FERM_C_FAK1	263..394	CDD:270011	35/184 (19%)
		PTKc_FAK	450..744	CDD:133187	104/293 (35%)
		Pkinase_Tyr	462..736	CDD:285015	102/274 (37%)
		Focal_AT	1249..1376	CDD:281606
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	8/85 (9%)
		TyrKc	1063..1311	CDD:197581	101/276 (37%)
		PTKc_Fes_like	1067..1315	CDD:270637	102/276 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468373
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840