DRSC/TRiP Functional Genomics Resources

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Protein Alignment Fak and LCK

DIOPT Version :10

Sequence 1:NP_001137718.1 Gene:Fak / 37233 FlyBaseID:FBgn0020440 Length:1500 Species:Drosophila melanogaster
Sequence 2:NP_001426075.1 Gene:LCK / 3932 HGNCID:6524 Length:567 Species:Homo sapiens


Alignment Length:434 Identity:123/434 - (28%)
Similarity:193/434 - (44%) Gaps:93/434 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   322 SKSGENTTEPELQNFNCNCQKIKTQIKISASNNVEDLV---ITCNGIN-TAESIADLIDGYCRLL 382
            |:|...:....:::|:.|..::....||...:|....:   ||..|:: ......:..||.|..|
Human   214 SESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRL 278

  Fly   383 SKDLEFTIWHRETNASNEDSAKALPNDATLGSNKSTSSQGKPMLTDDYAEIGLLEGEGDYSTPTV 447
            |:..:                              |....||...|:                  
Human   279 SRPCQ------------------------------TQKPQKPWWEDE------------------ 295

  Fly   448 RNYELDRALITPSAKIGVGQFGDVYVGTYTLPKLGKGKNLAGNGKNSNSDQRNADSRPDVIQVAI 512
              :|:.|..:....::|.||||:|::|.|             ||..               :||:
Human   296 --WEVPRETLKLVERLGAGQFGEVWMGYY-------------NGHT---------------KVAV 330

  Fly   513 KTCKAND-DPEKTENFLAEAYIMQKFDHPHIIRLIGICSVMPIWIVMELAKLGELRAYLKTNSE- 575
            |:.|... .|:.   |||||.:|::..|..::||..:.:..||:|:.|..:.|.|..:|||.|. 
Human   331 KSLKQGSMSPDA---FLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGI 392

  Fly   576 RLSHGTLLKYCYQLSTALSYLESKKFVHRDIAARNVLVSSPTCVKLADFGLSRWVSDQSYYHSTP 640
            :|:...||....|::..::::|.:.::|||:.|.|:|||.....|:|||||:|.:.|.. |.:..
Human   393 KLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNE-YTARE 456

  Fly   641 TVALPIKWMSPESINFRRFTTASDVWMFGVCIWEILMLGVKPFQGVKNSDVILKLENGERLPLPP 705
            ....||||.:||:||:..||..||||.||:.:.||:..|..|:.|:.|.:||..||.|.|:..|.
Human   457 GAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPD 521

  Fly   706 NCPPRLYSLMSQCWAYEPLKRPNFKRIKETLHEILIEDSINSSE 749
            |||..||.||..||...|..||.|..::..|     ||...::|
Human   522 NCPEELYQLMRLCWKERPEDRPTFDYLRSVL-----EDFFTATE 560

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FakNP_001137718.1 B41 24..267 CDD:214604
FERM_B-lobe 152..257 CDD:271216
FERM_C_FAK1 263..394 CDD:270011 15/75 (20%)
PTKc_FAK 450..744 CDD:133187 102/295 (35%)
Focal_AT 1250..1376 CDD:460992
LCKNP_001426075.1 None
Blue background indicates that the domain is not in the aligned region.

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