DRSC/TRiP Functional Genomics Resources

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Protein Alignment Fak and ptk2aa

DIOPT Version :9

Sequence 1:NP_001137718.1 Gene:Fak / 37233 FlyBaseID:FBgn0020440 Length:1500 Species:Drosophila melanogaster
Sequence 2:NP_942114.1 Gene:ptk2aa / 386705 ZFINID:ZDB-GENE-031114-5 Length:1045 Species:Danio rerio


Alignment Length:1395 Identity:433/1395 - (31%)
Similarity:619/1395 - (44%) Gaps:437/1395 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 HMPNKSFKA-----VRFNVKETVFHVIRRTVEDLGTDGRTPSIQRYAC---RMLNMITKEVIWLA 83
            |..|.|..:     :|......|..:|::.|:       ...:|...|   |:.::.:.:|.|| 
Zfish    42 HFENNSEHSTWSSNIRHGDATDVRGIIQKIVD-------IHKVQHVVCFGLRLTHVPSGDVHWL- 98

  Fly    84 RSTSMQKVLSHILTPGCSNVDCPNNQSELDEVLLEHGRRITDNRVWRVELRVRYVPNNIQELFEE 148
               ...:.:||:             :.:.::      :|..|.  ||.|||:||:|......|.|
Zfish    99 ---HPDEGVSHV-------------REKFEQ------KRPQDE--WRYELRIRYLPKGFLTQFTE 139

  Fly   149 DKATCFYYFNQVKEDFIQANVTAIDTEVAVQLCCLGIRHYFKNITVKAPDKKQHIDYIEKEIGFK 213
            ||.|..|::.|||.|::......::.|||::|.||.||.:::.:...|.|||.:.:.:||::|.:
Zfish   140 DKPTLNYFYQQVKNDYMLEVADQVEQEVALKLGCLEIRRFYREMRGNALDKKSNYELLEKDVGLR 204

  Fly   214 SFLPQSVIATSKPKNLKKLIQVGYKKVYNYNDIEYLTRFFDLLKNIYLTNFEQFSVTLSSAWNIS 278
            .|.|:|::.:.|.|.|:|.||..:|:..|.||.:.:.:||::|..:|..:.|.|...|.|:|.||
Zfish   205 RFFPKSLLESVKAKTLRKQIQQTFKQFANLNDEQSVLKFFEILAPVYRFDKECFRCALGSSWVIS 269

  Fly   279 GILHVGPHIGISYQTHPQASLKNVAQFKDVVSIK-TCTLPKEKLSKSGENTTEPELQNFNCNCQK 342
            ..|.:||..||||.|...::..::|....|.||. :|...||:                      
Zfish   270 VDLAIGPEEGISYLTDKGSTPTHLANLTQVQSIHYSCVEEKER---------------------- 312

  Fly   343 IKTQIKISASNNVEDLVITCNGINTAESIADLIDGYCRLLSKDLEFTIWHRETNASNE------- 400
             |..:::..:...|.|.|:....:|||::|||||||||||             ||.|:       
Zfish   313 -KGVLQLDVAGAAEPLTISTPSFSTAENMADLIDGYCRLL-------------NAVNQSFIIRPQ 363

  Fly   401 -DSAKALPNDATLGSNK-------------STSSQGKPMLTDDYAEIGLLEGEGDYSTPTVRNYE 451
             |..:|||:...|.:|:             |.|.      |||||||  ::.|..|:.|:.::||
Zfish   364 KDGERALPSIPKLANNEKRLEGIRAGVRAISVSE------TDDYAEI--IDEEDTYTMPSTQDYE 420

  Fly   452 LDRALITPSAKIGVGQFGDVYVGTYTLPKLGKGKNLAGNGKNSNSDQRNADSRPDVIQVAIKTCK 516
            :.|..|.....||.||||||:.|.|..|:                       .|. :.|||||||
Zfish   421 IQRDRIELGRCIGEGQFGDVHQGVYISPE-----------------------NPS-LSVAIKTCK 461

  Fly   517 ANDDPEKTENFLAEAYIMQKFDHPHIIRLIGICSVMPIWIVMELAKLGELRAYLKTNSERLSHGT 581
            ........|.||.||..|::||||||::||||.:..|:||:|||..|||||::|:.....|...|
Zfish   462 NCTSDSVREKFLQEALTMRQFDHPHIVKLIGIITENPVWIIMELCTLGELRSFLQVRKYNLDLST 526

  Fly   582 LLKYCYQLSTALSYLESKKFVHRDIAARNVLVSSPTCVKLADFGLSRWVSDQSYYHSTPTVALPI 646
            |:.:.|||||||:|||||:|||||||||||||||..||||.||||||::.|.|||.::.. .|||
Zfish   527 LILFAYQLSTALAYLESKRFVHRDIAARNVLVSSIDCVKLGDFGLSRYMEDSSYYKASKG-KLPI 590

  Fly   647 KWMSPESINFRRFTTASDVWMFGVCIWEILMLGVKPFQGVKNSDVILKLENGERLPLPPNCPPRL 711
            |||:||||||||||:||||||||||:|||||.|:||||||||:|||.::||||||.:|.||||.|
Zfish   591 KWMAPESINFRRFTSASDVWMFGVCMWEILMFGIKPFQGVKNNDVIGRIENGERLAMPQNCPPTL 655

  Fly   712 YSLMSQCWAYEPLKRPNFKRIKETLHEILIEDSINSSETLKREQRKVASMSWIGSDDIDIPPSKP 776
            ||||::||||:|.|||.|..:|..|..||.|:.:...|..:.|.|:..::||...:..:.|| ||
Zfish   656 YSLMTKCWAYDPSKRPRFTELKTQLSTILDEEKLQQEERFRMEMRRQVTVSWDAGNSDEAPP-KP 719

  Fly   777 SRVMHDPDITGLMPETTGLPQTYIIAQNPAVLAKLMMENQKRGINPAAYTTPASVFNTLAVGLDD 841
            ||              .|.|                                             
Zfish   720 SR--------------PGYP--------------------------------------------- 725

  Fly   842 SNPNVSLKTTKLPAADLLKLDPIAESERLRSQFSANSSASQLANPLTASVNPHESLNSHQAGMFT 906
                                             |..||.....:|      .|...::|..|   
Zfish   726 ---------------------------------SPRSSDGYFPSP------QHAGQHNHYQG--- 748

  Fly   907 GSLPSKSSFVVCPPQTEEHMQAENISNPSVSKVSGYSLYGSLERHQPPPAKAMHSKGGSLERHQS 971
                                             |||            ||..:.|.|        
Zfish   749 ---------------------------------SGY------------PAAHVSSPG-------- 760

  Fly   972 LMSAQNLVFYNTKPPPNCTNTAERSRSMERNTYFHAYRQQMKTSIECEALPEEIYDFGGIGLKTC 1036
                                             |.|     :|||   ..|.|.::.        
Zfish   761 ---------------------------------FPA-----QTSI---LDPLESWNH-------- 776

  Fly  1037 VSARQQPKFSPMVNVRPAELGQVQNTDCMGLQQNIPMDSFGVISPHNLDESL-RHQREME--RQW 1098
               ||:|...|......|.:|:.|           ||::      |.::|:| :.|::||  ::|
Zfish   777 ---RQEPPTWPANAEDGAAVGRTQ-----------PMNT------HLMEETLIKQQQQMEEDQRW 821

  Fly  1099 MTS-----GPQSITVNPNISISEGAACLATLQAEAMGNQGIHNVLGEKLRQQQKDSNSDSEWLIQ 1158
            :..     .|:|  .|...||....|.|.|    .||.|.::..:|                   
Zfish   822 LEQEESFLKPES--RNSRSSIDREDAALQT----PMGKQHVYQPVG------------------- 861

  Fly  1159 EELLRSCSIPQGSLNDHQAQMFKLDFMSAGPSSLPDCSNSSSRPMTPNANLSSLKSNHSSADHLS 1223
                                  |.|.: |.|...|       ||..|              .||:
Zfish   862 ----------------------KTDLV-APPKKPP-------RPGAP--------------AHLT 882

  Fly  1224 SLTSAEE-QMGSNARNLGSAVPSRPP----NRADDEVYCATTLVVKSIMALSQGVEKANTEGYLE 1283
            :|:.|:. ..|.....|.....|.||    :|::|:||...|.:||:::.:|..::.|..|.|:.
Zfish   883 NLSPADSYNEGVKPWRLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSRIQPALPEEYVP 947

  Fly  1284 LVKNVGVKLRNLLTSVDKISIIFPAQALKEVQMAHQVLSKDMHELVSAMRLAQQYSDTTLDCEYR 1348
            :||:||:.||.||.:||:...:.||...:|::||.::|:.|:.||:|.|||||||..|:|..:|:
Zfish   948 MVKDVGLALRTLLATVDETIPVLPAHTHREIEMAQKLLNSDLAELISKMRLAQQYMLTSLQQDYK 1012

  Fly  1349 KSMLSAAHVLAMDAKNLFDVVDSIRQRYQH 1378
            |.||:|||.||:|||||.||:...|.:..|
Zfish  1013 KQMLTAAHALAVDAKNLLDVIYQARLKMSH 1042

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FakNP_001137718.1 B41 24..267 CDD:214604 68/247 (28%)
FERM_B-lobe 152..257 CDD:271216 36/104 (35%)
FERM_C_FAK1 263..394 CDD:270011 40/131 (31%)
PTKc_FAK 450..744 CDD:133187 168/293 (57%)
Pkinase_Tyr 462..736 CDD:285015 160/273 (59%)
Focal_AT 1249..1376 CDD:281606 57/126 (45%)
ptk2aaNP_942114.1 B41 36..258 CDD:214604 68/247 (28%)
FERM_B-lobe 143..247 CDD:271216 36/103 (35%)
FERM_C_FAK1 254..364 CDD:270011 43/145 (30%)
PTKc_FAK 419..688 CDD:133187 168/293 (57%)
Pkinase_Tyr 426..680 CDD:285015 161/278 (58%)
Focal_AT 911..1040 CDD:281606 57/128 (45%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 322 1.000 Domainoid score I1190
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 628 1.000 Inparanoid score I834
OMA 1 1.010 - - QHG46813
OrthoDB 1 1.010 - - D29350at33208
OrthoFinder 1 1.000 - - FOG0002650
OrthoInspector 1 1.000 - - otm26029
orthoMCL 1 0.900 - - OOG6_105566
Panther 1 1.100 - - LDO PTHR46221
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1755
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
1110.980

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