DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Fak and Ack

DIOPT Version :9

Sequence 1:NP_001137718.1 Gene:Fak / 37233 FlyBaseID:FBgn0020440 Length:1500 Species:Drosophila melanogaster
Sequence 2:NP_647859.1 Gene:Ack / 38489 FlyBaseID:FBgn0028484 Length:1073 Species:Drosophila melanogaster


Alignment Length:1139 Identity:253/1139 - (22%)
Similarity:412/1139 - (36%) Gaps:347/1139 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   412 LGSNKSTSSQGKPMLTDDYAEIGLLEGEGDYSTPTVRNYELDRALITPSAKIGVGQFGDVYVGTY 476
            :|..|..||:.:.....:.:     :|.|...|..:  :|.|   ||...|:|.|.||.|..|.:
  Fly    88 IGGGKQPSSKKQSSAARESS-----QGNGTQLTCLI--HEKD---ITMGLKLGDGSFGVVRRGEW 142

  Fly   477 TLPKLGKGKNLAGNGKNSNSDQRNADSRPDVIQVAIKTCKAND--DPEKTENFLAEAYIMQKFDH 539
            :....||                       ||.||:|..|:::  .|...::|..|...|...||
  Fly   143 SASPAGK-----------------------VIPVAVKVLKSDNLTQPGIIDDFFREVQAMHALDH 184

  Fly   540 PHIIRLIGICSVMPIWIVMELAKLGELRAYLKTNSERLSHGTLLKYCYQLSTALSYLESKKFVHR 604
            .:::||.|:....|:.::.|||:.|.|...|:......|...:..:..|:.|.::|||.|:|:||
  Fly   185 ANLVRLYGVVLSQPMMMITELAERGSLLDTLRKQCRHTSLTIIWNWSVQIVTGMAYLEQKRFLHR 249

  Fly   605 DIAARNVLVSSPTCVKLADFGLSRWV-SDQSYYHSTPTVALPIKWMSPESINFRRFTTASDVWMF 668
            |:|.||||:::...:|:.||||.|.: .:...|..:....:|..|.:|||:.||:|:.|||.|||
  Fly   250 DLACRNVLLAAGNKIKIGDFGLMRALPQEDDCYVMSEHKKVPFPWCAPESLRFRQFSHASDTWMF 314

  Fly   669 GVCIWEILMLGVKPFQGVKNSDVILKLE-NGERLPLPPNCPPRLYSLMSQCWAYEPLKRPNFKRI 732
            ||.:||:...|..|:.|:..|.::.|:: .||||..|..|||.:|::|.|||...|.:||.|..:
  Fly   315 GVTLWEMFSFGEDPWVGLNGSQILRKIDREGERLHQPDACPPDVYAMMLQCWDKTPAERPTFAAL 379

  Fly   733 KETLHEILIEDSINSSETLKREQRKVASMSWIGSDDIDIPP-SKPSRVMHDPDITGLMPETT--- 793
            ||.|                      ||||         || .:.||..|:.....:.|..|   
  Fly   380 KEYL----------------------ASMS---------PPVMRASRSHHESKGLQIEPGDTIAI 413

  Fly   794 --GLPQTYII-AQNP-----AVLAKLMMENQKRG----------INPAAYTTPASVF--NTLAVG 838
              |..:..:| .||.     .:..:.::|.:|.|          :...:.::|....  ...|:.
  Fly   414 IDGRHELKLIKGQNQRTFDIGIFPRNLLEQRKVGAAGDVVMRSSVGNGSSSSPFGFCWGGAAAMA 478

  Fly   839 LDDSNPNVSLKTTKLPAADLLKLDPIAESERLRSQFSANSSASQLANPLTASVNPHESLNSHQAG 903
            ..|.........|..|.|          .|| :|..|...:.::|.|.....:....:: .|: |
  Fly   479 NGDDRQRKCASMTNQPHA----------KER-KSTSSKQFAYNKLVNDSATGLQRRNAV-KHK-G 530

  Fly   904 MFTGSLPSKSSFVVCPPQTEEHMQAENISNPSV-----------------SKVSGYSLYGSLERH 951
            :..|  |.:..    |||.::.....:|| |.:                 |.:...|.:..|:..
  Fly   531 VVVG--PQRPP----PPQFQQEGILIDIS-PDMRPIAEAGTGGAKGAGDSSSLQADSSFCILDAP 588

  Fly   952 QPPPAKAMHSKGGSLERHQSLMSAQNLVFYNTKP-----------------------PPNCTNTA 993
            ...|..|..|..|.|.        .:..:||.:|                       ||..:||.
  Fly   589 IDVPTYAGSSGSGDLN--------VSPTYYNEQPQFDFDPAKMTASPGRLQPPPYQMPPTYSNTM 645

  Fly   994 E--RSRSMERNTYFHAYRQQMKTSIECEALPEEIYDFGGIGLKTCVS----------ARQQPKFS 1046
            |  :.|.:        ::||:.|.:      .|...|....::|.|:          |...|  :
  Fly   646 EFVQKRDL--------HQQQLATPV------RERDPFDTTNVETTVALYSNFNQSLEAASPP--A 694

  Fly  1047 PMVN---VRPAELGQVQNTDCMGLQQNIPMDSFGVISPHNLDESLRHQREMERQWMTSGPQSITV 1108
            |:.|   ||.:..|..::.     ::|||                    .:|...|.....::|:
  Fly   695 PIYNSPSVRKSLFGGSKSN-----KENIP--------------------ALESAAMQLNLSNLTL 734

  Fly  1109 NPNISISEGAACLATLQ-AEAMGNQGIHNVLGEK--LRQQQKDSNSDSEWLIQEELLRSCSIPQG 1170
            .     ...|.|:..:: ..|....|   ||.:|  :.:.:||..|:.:...|||..|       
  Fly   735 E-----RHDATCIQPVEPVPAPPGDG---VLLDKSFIAELEKDMYSNGQNRAQEEYQR------- 784

  Fly  1171 SLNDHQAQMFKLDFMSAGPSSLPDCSNSSSRPMTPNANLSSLK---------SNHSSADHLSS-- 1224
                :..||:                  :|:.|....||:.||         |||||....:|  
  Fly   785 ----NSTQMY------------------ASKDMVYKQNLTPLKNGAAPGSVHSNHSSPSSTASPK 827

  Fly  1225 --------------------------------------LTSAEEQMGSNARNLGS---------- 1241
                                                  ...||||:..|.|:...          
  Fly   828 QNNVEAAAAAAATTQSVVNRIWYEQVASTQSEYYAQPPTEQAEEQIYQNHRHQQQQQQELNHSFV 892

  Fly  1242 AVPSR---PPNRADDEVYCATTLVVKSIMALSQGVEKANTEGYLELVKNVGVKLRNLLTSVDKIS 1303
            |:.:|   |.|.|    |.:|..:..::.|.:.|     :..|.::....|..|.:.:|..|.:.
  Fly   893 AISNRVVAPKNNA----YSSTASLYDAVAASTAG-----STYYGQVPNGSGAVLYDEVTQDDYLR 948

  Fly  1304 IIFPAQALKEVQMAHQVLSKDMHELVSAMRLAQQYSDTTLDCEYRKSMLSAAHVLAMDAKNLFD- 1367
            ...||........|.|:..:     :..|||.||            ..|..||.|.....:.:. 
  Fly   949 PTRPAPLAPPPLSAQQIQRR-----MEKMRLQQQ------------QQLDGAHQLYAPVPSDYGR 996

  Fly  1368 VVDSIRQRYQHLFPPSATKETSCSSSFESTSGSI 1401
            ..:.::|..|.|  .|:..|....::..:.||.:
  Fly   997 EQEKLQQLMQEL--GSSAVEQDVRNALRAASGDV 1028

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FakNP_001137718.1 B41 24..267 CDD:214604
FERM_B-lobe 152..257 CDD:271216
FERM_C_FAK1 263..394 CDD:270011
PTKc_FAK 450..744 CDD:133187 101/297 (34%)
Pkinase_Tyr 462..736 CDD:285015 96/277 (35%)
Focal_AT 1249..1376 CDD:281606 25/127 (20%)
AckNP_647859.1 SAM_TNK-like 14..75 CDD:188938
PTKc_Ack_like 128..385 CDD:270636 97/301 (32%)
UBA_TNK1 1031..1070 CDD:270513
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45468379
Domainoid 1 1.000 165 1.000 Domainoid score I1208
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
32.840

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