DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fak and Egfr

DIOPT Version :9

Sequence 1:	NP_001137718.1	Gene:	Fak / 37233	FlyBaseID:	FBgn0020440	Length:	1500	Species:	Drosophila melanogaster
Sequence 2:	NP_476759.1	Gene:	Egfr / 37455	FlyBaseID:	FBgn0003731	Length:	1426	Species:	Drosophila melanogaster

Alignment Length:	715	Identity:	171/715 - (23%)
Similarity:	279/715 - (39%)	Gaps:	185/715 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   291 YQTHPQASLKNVAQFKDVVSIKTCTLPKEKLSKS-------GENTTEPELQN--FNC--NC---- 340
            :|.||:.:              .||.|.....||       ..|.|.|.:.:  |||  .|
  Fly   787 FQCHPECN--------------GCTGPGADDCKSCRNFKLFDANETGPYVNSTMFNCTSKCPLEM 837

  Fly   341 QKIKTQI---------------KISASNNVEDLVITCNGINTAESIADL--IDGYCRLLSKDLEF 388
            :.:..|.               ||:|:.:| :::....|.....:|..|  :...||...|..:.
  Fly   838 RHVNYQYTAIGPYCAASPPRSSKITANLDV-NMIFIITGAVLVPTICILCVVTYICRQKQKAKKE 901

  Fly   389 TIWHRETNASNEDSAKALPNDATLGSNKSTSSQGKPMLTDDYAEIGLLEGEGDYSTPTVRNYELD 453
            |:......:..|||....|::  :|:|..                         ....|::.||.
  Fly   902 TVKMTMALSGCEDSEPLRPSN--IGANLC-------------------------KLRIVKDAELR 939

  Fly   454 RALITPSAKIGVGQFGDVYVGTYTLPKLGKGKNLAGNGKNSNSDQRNADSRPDVIQVAIKTCKAN 518
            :..:     :|:|.||.||.|.:    :.:|:|:.                   |.||||....:
  Fly   940 KGGV-----LGMGAFGRVYKGVW----VPEGENVK-------------------IPVAIKELLKS 976

  Fly   519 DDPEKTENFLAEAYIMQKFDHPHIIRLIGICSVMPIWIVMELAKLGELRAYLKTNSERLSHGTLL 583
            ...|.:|.||.|||||...:|.::::|:.:|....:.::.:|..||.|..|::.|.:::....||
  Fly   977 TGAESSEEFLREAYIMASVEHVNLLKLLAVCMSSQMMLITQLMPLGCLLDYVRNNRDKIGSKALL 1041

  Fly   584 KYCYQLSTALSYLESKKFVHRDIAARNVLVSSPTCVKLADFGLSRWVSDQSYYHSTPTVALPIKW 648
            .:..|::..:||||.|:.||||:|||||||.:|:.||:.||||::.:|..|..:......:||||
  Fly  1042 NWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGGKMPIKW 1106

  Fly   649 MSPESINFRRFTTASDVWMFGVCIWEILMLGVKPFQGVKNSDVILKLENGERLPLPPNCPPRLYS 713
            ::.|.|..|.||:.||||.|||.|||:|..|.:|.:.:...|:...:|.|.:|..|..|...:|.
  Fly  1107 LALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYC 1171

  Fly   714 LMSQCWAYEPLKRPNFKRIKETLHEILIE---------DSIN-----SSETLKREQRKVASMSWI 764
            .:..||..:...||.||::.....|...:         |...     :|:..|...||:|..: .
  Fly  1172 TLLSCWHLDAAMRPTFKQLTTVFAEFARDPGRYLAIPGDKFTRLPAYTSQDEKDLIRKLAPTT-D 1235

  Fly   765 GSDDIDIP-----PSKPSRVMHDPDITGLMPE-------------TTGLPQTYIIAQNPAVLAKL 811
            ||:.|..|     |.......|..|.|..:|:             :||..:|...|:...| ..|
  Fly  1236 GSEAIAEPDDYLQPKAAPGPSHRTDCTDEIPKLNRYCKDPSNKNSSTGDDETDSSAREVGV-GNL 1299

  Fly   812 MME-----------------NQKRGIN----------------------PAAYTTPASVFNTLAV 837
            .::                 |....||                      |.:...|..:.|...:
  Fly  1300 RLDLPVDEDDYLMPTCQPGPNNNNNINNPNQNNMAAVGVAAGYMDLIGVPVSVDNPEYLLNAQTL 1364

  Fly   838 GLDDS---NPNVSLKTTKLPAADLLKLDPIAESERLRSQFSANSSASQLANPLTASVNPHESLNS 899
            |:.:|   ...:.:....:|....:|: |:..||...|.....:...:...||      |.:.|:
  Fly  1365 GVGESPIPTQTIGIPVMGVPGTMEVKV-PMPGSEPTSSDHEYYNDTQRELQPL------HRNRNT 1422

Fly 900 899
Fly 1423 1422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fak	NP_001137718.1	B41	24..267	CDD:214604
		FERM_B-lobe	152..257	CDD:271216
		FERM_C_FAK1	263..394	CDD:270011	27/134 (20%)
		PTKc_FAK	450..744	CDD:133187	98/302 (32%)
		Pkinase_Tyr	462..736	CDD:285015	95/273 (35%)
		Focal_AT	1249..1376	CDD:281606
Egfr	NP_476759.1	Recep_L_domain	419..547	CDD:279382
		GF_recep_IV	572..684	CDD:291509
		FU	573..>606	CDD:238021
		FU	617..659	CDD:214589
		FU	662..716	CDD:214589
		FU	739..786	CDD:238021
		FU	784..834	CDD:214589	14/60 (23%)
		PTKc_EGFR_like	930..1208	CDD:270648	99/305 (32%)
		STYKc	938..1194	CDD:214568	96/283 (34%)
		Recep_L_domain	128..239	CDD:279382
		Furin-like	253..401	CDD:279142
		FU	255..292	CDD:214589
		FU	302..345	CDD:238021
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.910