Protein Alignment Fak and Ack-like

DIOPT Version :9

• Sequence 1: NP_001137718.1
• Gene: Fak / 37233
• FlyBaseID: FBgn0020440
• Length: 1500
• Species: Drosophila melanogaster
• Sequence 2: NP_001260935.1
• Gene: Ack-like / 36442
• FlyBaseID: FBgn0263998
• Length: 1495
• Species: Drosophila melanogaster
• Alignment Length: 1316
• Identity: 303/1316 - (23%)
• Similarity: 475/1316 - (36%)
• Gaps: 361/1316 - (27%)

  Fly   326 ENTTEPELQNFNCNCQKIKTQIKISASNNV-----EDLVITCNGINTAESIADLIDGYCRLLSKD 385
            |..||.|||.:   ...:|.::||:.:...     |||...  |::..|         .|.|.|.
  Fly    10 EFLTESELQQY---YNAVKNELKITNAAQFKYAADEDLRFI--GLSRPE---------IRRLRKF 60

  Fly   386 LEFTIWHR------------ETNASNEDSAKALPNDATLGSNKSTSSQGKPMLTDDYAEIGLLEG 438
            .|....|.            .|....|::.......|..||:.|..|.              |..
  Fly    61 YEKHFPHSYLSKIKRLLQAPGTMVKREEAPGGGSQVALDGSSASACSS--------------LAA 111

  Fly   439 EGDYSTPT-VRN--YELDRALITPSAKIGVGQFGDVYVGTYTLPKLGKGKNLAGNGKNSNSDQRN 500
            :...|:|: |.|  :.:....|:.:.::|.|:||.|..|.:                 ||.::|
  Fly   112 KNGASSPSKVPNNKHIIPADSISVNKQLGTGEFGIVQQGVW-----------------SNGNER- 158

  Fly   501 ADSRPDVIQVAIK-TCKANDDPEKTENFLAEAYIMQKFDHPHIIRLIG-ICSVMPIWIVMELAKL 563
                   |||||| .|:........| ||.||.||...:|.:|:||.| :.:...:.:|.|||.|
  Fly   159 -------IQVAIKCLCRERMQSNPME-FLKEAAIMHSIEHENIVRLYGVVLATDSLMLVTELAHL 215

  Fly   564 GELRAYLKTNSERLSH---GTLLKYCYQLSTALSYLESKKFVHRDIAARNVLVSSPTCVKLADFG 625
            ..|...||.:..|:|.   .||.::..|:...:.|||.|:.:|||:||||:||.|...||::|||
  Fly   216 RSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFG 280

  Fly   626 LSRWVSDQSYYHST---PTVALPIKWMSPESINFRRFTTASDVWMFGVCIWEILMLGVKPFQGVK 687
            |||.:.....|:.|   ..:.|||.|.:||.||:.|||.|||||.||||:||:...|.:|:..:.
  Fly   281 LSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASDVWAFGVCLWEMFSYGFQPWAALT 345

  Fly   688 NSDVILKLE--NGERLPLPPNCPPRLYSLMSQCWAYEPLKRPNFKRIKETLHEILIEDSINSSET 750
            ...::..::  |.:||..|..||...|:||.:||..:..|||.|..|.:.|.:
  Fly   346 GLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEIYDQLPD------------ 398

  Fly   751 LKREQRK-VASMSWIGSDDIDIPPSKPSRVMHDPDITGLMPETTGLP----------QTYIIAQN 804
            :|.||.| |.:.:         .|.|...:....||..::...||.|          ..|....|
  Fly   399 MKPEQLKAVVNCT---------EPKKDHLLYRQGDIISVLDRNTGTPFWKGVLSTGKTGYFNPSN 454

  Fly   805 PAVLAKLMMEN-------------QKRGINPAAYTTPASVF-NTLAVGLD----------DSNPN 845
            .....:.:..:             .||.:.....:.|.:.| :|..||:|          .|:.|
  Fly   455 TVAFLEGLPSSTRDSFSRVSDHRISKRKLRTEMISKPQNDFKHTGHVGIDGATFGDIAFLGSSQN 519

  Fly   846 VS-----LKTTKLPAADL----LKLDPIAES-ERLRSQFSANSSASQLANPLTASVNP------- 893
            .:     :.|...|:.|:    |.|.|...| :.|::........:.....:..|:||
  Fly   520 YNHVPKQIVTPYKPSEDIEQTPLLLPPTPTSPDSLQTASGYFPEGANSGGAMGTSMNPTFIPSAE 584

  Fly   894 HESLNSHQAGMFTGSLPSKSSFVVCPPQTEEHMQAENISNPSVSKVSGYSLYGSLERHQPPPAKA 958
            |........|..:....|.|:....|.:.::.::            .|...||:       ..|:
  Fly   585 HTPKLIATNGQSSFDFASGSTNPFFPNRGDDELE------------FGLHNYGA-------DGKS 630

  Fly   959 MHSKGGSLERHQSLMSAQNLVFYNTKPPPNCTNTAERSRSMERNTYFHAYRQQMKTSIECE---- 1019
            :||:.|                  .:|         .|||:..:.  |.|.:.....|..:
  Fly   631 VHSETG------------------WRP---------TSRSIVDDP--HEYHEISDDEIAADKLDF 666

  Fly  1020 --ALPEEIYD-FGGIGLKTCVSARQQPKFSPMVNVR-----PAELGQVQNTDCMGLQQNIPMDSF 1076
              :|.:||.. ||.|...| .|..:.|.|..:.|..     .|:|||...            |:.
  Fly   667 GPSLLDEINSMFGSISAAT-GSHPKSPGFDHVNNKNEITEMSAKLGQKSG------------DTN 718

  Fly  1077 GVISPHNLDESLRHQREMERQWMTSGPQSITVNPNISISEGAACLATLQAEAMGNQGIHNVLGEK 1141
            |....|.|..:|..::       :||    ||.| ||:.:          |.:.|..| .:..|.
  Fly   719 GNKHGHGLLPTLSKKK-------SSG----TVKP-ISVKD----------EKILNHAI-EIANEI 760

  Fly  1142 LRQQQKDSNSDSEWLIQEELLR-SCSIPQGSLNDHQAQMFKLDFMSAGPSSLPDCSNSSSRPMTP 1205
            ..:...|..||...:|.....: |...|..|.|....:...|.  ::|.:..|...|:|..|...
  Fly   761 SARSMIDLVSDQTPVIHSPKRKFSFRFPHLSNNGSGDKSGGLG--TSGSAHTPTHGNASPFPKKK 823

  Fly  1206 N--------------ANLSSLKSN-----------------HSSADHLSSLTSAEEQMGSNARNL 1239
            |              .:||.:|::                 ..|.:.||...:.|.:.|.
  Fly   824 NFTEELQSIPDIQRFRSLSEIKNSTDLRVPIFDKESSDFLFQKSREILSRPLNLERECGD----- 883

  Fly  1240 GSAVPSRPPNRADDEVYCATTLVVKSIMALSQGVEKANTE---GYLELVKN------VGVKLRNL 1295
                 .:||...||           :||.:...::..|.:   .|.||.|:      :..:|.::
  Fly   884 -----EQPPKSIDD-----------NIMDIENTLKALNLDFMHTYTELDKSDSNDTILNDQLPHM 932

  Fly  1296 LTSVDKISIIFPAQALKEVQMAHQVLSKDMHELVSAMRLAQQYSDTTLDCEYRKSMLSAAHVLAM 1360
            .:..|.||     .|...::.|....|..:..:.. ...|..:.|..|...:.::.||||  ..:
  Fly   933 ASLDDGIS-----SATGSLKSAVYSYSNGVQTMFD-FNAATSHLDKHLQYMHNQAQLSAA--APV 989

  Fly  1361 DAKNLFDVVDSIRQRYQHLFPPS--ATKETSCSSSFESTSGS-----------------IVAEPV 1406
            |.|.:.|...|.        |.:  |:::|:.|.|..|:..|                 ..|.||
  Fly   990 DPKPMDDKRSST--------PDTGFASRDTNISLSRRSSQKSSYSPQESFHFPLKGEPLFSAPPV 1046

  Fly  1407 NDLGGYIKTSTSGDLLQNTGIYDNDLHHSFNSQLQLQNP-KASIDL-SGGGSLQRGMSLGLDTTR 1469
            ...|||      ..|....| |:...:.:....|...:| |:.:.| :..||:..|.......:.
  Fly  1047 VMSGGY------ASLKDELG-YERFGNGATKQMLASASPIKSGVGLNASSGSVYMGSKGYRQRST 1104

  Fly  1470 STNEPLRIVEETLGSP 1485
            |.||....:...|..|
  Fly  1105 SFNESFHPISPVLSEP 1120

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fak	NP_001137718.1	B41	24..267	CDD:214604
		FERM_B-lobe	152..257	CDD:271216
		FERM_C_FAK1	263..394	CDD:270011	19/84 (23%)
		PTKc_FAK	450..744	CDD:133187	107/303 (35%)
		Pkinase_Tyr	462..736	CDD:285015	105/283 (37%)
		Focal_AT	1249..1376	CDD:281606	27/135 (20%)
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938	18/68 (26%)
		STYKc	133..396	CDD:214568	106/288 (37%)
		PTKc_Ack_like	137..398	CDD:270636	106/286 (37%)
		SH3	400..454	CDD:214620	13/62 (21%)
		CRIB	486..525	CDD:238077	8/38 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468384
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840