DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fak and CG10702

DIOPT Version :9

Sequence 1:	NP_001137718.1	Gene:	Fak / 37233	FlyBaseID:	FBgn0020440	Length:	1500	Species:	Drosophila melanogaster
Sequence 2:	NP_001188841.1	Gene:	CG10702 / 35181	FlyBaseID:	FBgn0032752	Length:	946	Species:	Drosophila melanogaster

Alignment Length:	665	Identity:	121/665 - (18%)
Similarity:	203/665 - (30%)	Gaps:	228/665 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 IRRTVEDLGTDGRTPSIQRYACRMLNMITKE--VIWLARSTSMQKVLSHILTP---GCSNVDCPN 107
            |:|....:|:..:..||.|....:|.:...|  :|.:.::.|         ||   |||:..|.:
  Fly   134 IQRGQVYIGSCPKLCSIGRVNWDLLTLTRGENNIIMVNKNCS---------TPVCSGCSSSHCWS 189

  Fly   108 NQSELDEVLLEHGRRITDNRVWRVELRVRYVPNNIQELFEEDKATCFYYFNQVKEDFIQANVTAI 172
            |                           .|...:|.|.....|                ||:.|.
  Fly   190 N---------------------------HYCQRSINENVANPK----------------ANINAC 211

  Fly   173 DTEVAVQLCCLGIRHYFKNITVKAPDKKQHIDYIEKEIGFKSFLPQSVIATSKPKNLKKLIQVGY 237
            ..|      |||   ..||.:....|...          .:......|...|.||:  |.:...|
  Fly   212 HEE------CLG---GCKNNSSSPADCSV----------CRGLSDDGVCVKSCPKD--KYVMENY 255

  Fly   238 KKVYNYNDIEYLTRFFDLLKNIYLTNFEQFSVTLSSAWNISG----ILHVGPHIGISYQTHPQAS 298
            ::.|        |:...:||:.|:.:..|......|.:..:.    :|.......||:.| |:..
  Fly   256 QRCY--------TKAECVLKHGYVISGSQCVAFCPSGYKTNNRSECVLCSPDEACISFCT-PEWP 311

  Fly   299 LK--NVAQFKDVVSIKTCTLPKEKLSKSGEN-TTEPELQNFNCNCQKIKTQIKISASNNVEDLVI 360
            .|  .|....|..:::.|.:....|..:..| ..|.:|.....:.::::..:|:..|:.:..|..
  Fly   312 GKAFTVYNLADAENLRGCQIFNGSLVITIRNKVNETQLYQSFTSMREVRGHVKVYRSSQLRSLQF 376

  Fly   361 TCNGINTAESI-ADLIDG--YCRLL------------SKDLEF----TIWHRETNASN---EDSA 403
                :...|.: .|.::.  |..:|            |:.|||    ...||.....|   .:..
  Fly   377 ----LRNLERVHGDPLENRHYSFILYDNKELSELWTPSRQLEFMEGGMFMHRNNKLCNRRMREFQ 437

  Fly   404 KALPNDATLGS-------------------------------NKSTSSQ-----GKPMLTDDYAE 432
            .|:.:|..|.|                               .||.:||     .:|:|...
  Fly   438 NAVTHDRALDSLQTNDQEVQCSPLKLQLYVQKRTHRSVKLSWLKSQTSQKIELIHRPLLPGK--- 499

  Fly   433 IGLLEGEGDYSTPTVRNYELDRALITPSAKIGVGQFGDVYVGTYTLPKLGKGKNLAGNGKNSNSD 497
              |...|.:...|........|.|:.|.                         :|..||.:...|
  Fly   500 --LYHEESELDAPICTRINWKRRLLFPD-------------------------DLIENGTHYLFD 537

  Fly   498 QRNADSRPDVIQVAIKTCKANDDPEKTENFLAE-AYIMQKFDHPHIIRLIGICSVMPIWIVMELA 561
            .  .|.:||...|.:.....||:..:.....:| .|:..:.|.|.          .|:   :||.
  Fly   538 L--DDLQPDTRYVVLLRTFGNDEAHEAYEARSELTYVQTELDIPK----------PPL---LELV 587

  Fly   562 KLGELRAYLKTNSERL------SHGTLLKYCYQLSTALSYLESKKFVHRDIAARNVLVSSPTCVK 620
            |        ||:|...      .|.:.|...::||....|:|.:.:.|:           |:.|
  Fly   588 K--------KTDSSLTVQMASHDHVSFLLTVFELSDDQDYIEQRNYCHQ-----------PSYV- 632

  Fly   621 LADFGLSRWVSDQSY 635
            ..|....||::.:.|
  Fly   633 WQDMDGPRWMAYEDY 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fak	NP_001137718.1	B41	24..267	CDD:214604	42/223 (19%)
		FERM_B-lobe	152..257	CDD:271216	18/104 (17%)
		FERM_C_FAK1	263..394	CDD:270011	27/156 (17%)
		PTKc_FAK	450..744	CDD:133187	37/193 (19%)
		Pkinase_Tyr	462..736	CDD:285015	34/181 (19%)
		Focal_AT	1249..1376	CDD:281606
CG10702	NP_001188841.1	Recep_L_domain	47..159	CDD:279382	6/24 (25%)
		Furin-like	171..297	CDD:279142	36/206 (17%)
		FU	210..258	CDD:238021	14/68 (21%)
		Recep_L_domain	328..441	CDD:279382	20/116 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468388
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930