DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fak and Btk29A

DIOPT Version :9

Sequence 1:	NP_001137718.1	Gene:	Fak / 37233	FlyBaseID:	FBgn0020440	Length:	1500	Species:	Drosophila melanogaster
Sequence 2:	NP_001097121.1	Gene:	Btk29A / 34132	FlyBaseID:	FBgn0003502	Length:	786	Species:	Drosophila melanogaster

Alignment Length:	379	Identity:	121/379 - (31%)
Similarity:	182/379 - (48%)	Gaps:	91/379 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   369 ESIADLIDGY--------CRLLSKDLEFTIWHRETNASNEDSAKALPNDATLGSNKSTSSQGKPM 425
            |:|.|||:.:        |||.|...:                :.:|..|.|..:|   .:..||
  Fly   479 ETIPDLINYHRHNSGGLACRLKSSPCD----------------RPVPPTAGLSHDK---WEIHPM 524

  Fly   426 LTDDYAEIGLLEGEGDYSTPTVRNYELDRALITPSAKIGVGQFGDVYVGTYTLPKLGKGKNLAGN 490
                  |:.|:|                        ::|.||||.|..|.:      :|.
  Fly   525 ------ELMLME------------------------ELGSGQFGVVRRGKW------RGS----- 548

  Fly   491 GKNSNSDQRNADSRPDVIQVAIKTCKANDDPEKTENFLAEAYIMQKFDHPHIIRLIGICSV-MPI 554
                             |..|:|..|.....|  ::|:.||.:|.|..||::::|.|:||. .||
  Fly   549 -----------------IDTAVKMMKEGTMSE--DDFIEEAKVMTKLQHPNLVQLYGVCSKHRPI 594

  Fly   555 WIVMELAKLGELRAYLKTNSERL--SHGTLLKYCYQLSTALSYLESKKFVHRDIAARNVLVSSPT 617
            :||.|..|.|.|..||:.:.:.|  :.|.||..|.|:|..::|||...::|||:||||.||.|..
  Fly   595 YIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSEN 659

  Fly   618 CVKLADFGLSRWVSDQSYYHSTPTVALPIKWMSPESINFRRFTTASDVWMFGVCIWEILMLGVKP 682
            .||:|||||:|:|.|..|..|..| ..||||..||.:|:.||::.||||.:||.:|||...|..|
  Fly   660 VVKVADFGLARYVLDDQYTSSGGT-KFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMP 723

  Fly   683 FQGVKNSDVILKLENGERLPLPPNCPPRLYSLMSQCWAYEPLKRPNFKRIKETL 736
            :..:||::|:.:::.|..|..|.:|...:|.:|..||::.|.:||.|:.:.:.|
  Fly   724 YGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQL 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fak	NP_001137718.1	B41	24..267	CDD:214604
		FERM_B-lobe	152..257	CDD:271216
		FERM_C_FAK1	263..394	CDD:270011	9/32 (28%)
		PTKc_FAK	450..744	CDD:133187	103/290 (36%)
		Pkinase_Tyr	462..736	CDD:285015	102/276 (37%)
		Focal_AT	1249..1376	CDD:281606
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702
		SH2_Tec_family	403..505	CDD:198188	9/25 (36%)
		PTKc_Tec_like	521..778	CDD:173637	108/318 (34%)
		Pkinase_Tyr	526..777	CDD:285015	104/305 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468349
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840