DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fak and Ptk2

DIOPT Version :9

Sequence 1:	NP_001137718.1	Gene:	Fak / 37233	FlyBaseID:	FBgn0020440	Length:	1500	Species:	Drosophila melanogaster
Sequence 2:	XP_038934399.1	Gene:	Ptk2 / 25614	RGDID:	3443	Length:	1140	Species:	Rattus norvegicus

Alignment Length:	1382	Identity:	430/1382 - (31%)
Similarity:	621/1382 - (44%)	Gaps:	415/1382 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 IRRTVEDLGTDGRTPSIQRYACRMLNMITKEVIWLARSTSMQKVLSHILTPGCSNVDCPNNQSEL 112
            :|..::.:....:...:..|..|:.::.::||.||           |: ..|.|:|        .
  Rat   108 VRGIIQKIVDSHKVKHVACYGFRLSHLRSEEVHWL-----------HV-DMGVSSV--------R 152

  Fly   113 DEVLLEHGRRITDNRVWRVELRVRYVPNNIQELFEEDKATCFYYFNQVKEDFIQANVTAIDTEVA 177
            ::..|.|     ....|:.|||:||:|......|.|||.|..:::.|||.|::......:|.::|
  Rat   153 EKYELAH-----PPEEWKYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKSDYMLEIADQVDQDIA 212

  Fly   178 VQLCCLGIRHYFKNITVKAPDKKQHIDYIEKEIGFKSFLPQSVIATSKPKNLKKLIQVGYKKVYN 242
            ::|.||.||..:..:...|.:||.:.:.:||::|.|.|.|:|::.:.|.|.|:||||..:::..|
  Rat   213 LKLGCLEIRRSYWEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKAKTLRKLIQQTFRQFAN 277

  Fly   243 YNDIEYLTRFFDLLKNIYLTNFEQFSVTLSSAWNISGILHVGPHIGISYQTHPQASLKNVAQFKD 307
            .|..|.:.:||::|..:|..:.|.|...|.|:|.||..|.:||..||||.|....:..::|.|..
  Rat   278 LNREESILKFFEILSPVYRFDKECFKCALGSSWIISVELAIGPEEGISYLTDKGCNPTHLADFNQ 342

  Fly   308 VVSIKTCTLPKEKLSKSGENTTEPELQNFNCNCQKIKTQIKISASNNVEDLVITCNGINTAESIA 372
            |.:|                    :..|.....:|...|:||:.:  .|.|.:|...:..||::|
  Rat   343 VQTI--------------------QYSNSEDKDRKGMLQLKIAGA--PEPLTVTAPSLTIAENMA 385

  Fly   373 DLIDGYCRLLSKDLEFTIWHRETNASNEDSAKALPNDATLGSNK-------STSSQG-------- 422
            |||||||||::...:..|...:     ::..:|||:...|.:|:       :.|..|
  Rat   386 DLIDGYCRLVNGATQSFIIRPQ-----KEGERALPSIPKLANNEKQGMRTHAVSVSGINHCQHKV 445

  Fly   423 ------KPML----------------TDDYAEIGLLEGEGDYSTPT-------VRNYELDRALIT 458
                  .|::                |||||||  ::.|..|:.|:       .|:||:.|..|.
  Rat   446 KKARRFLPLVFCSLEPPPTDEISGDETDDYAEI--IDEEDTYTMPSKSYGIDEARDYEIQRERIE 508

  Fly   459 PSAKIGVGQFGDVYVGTYTLPKLGKGKNLAGNGKNSNSDQRNADSRPDVIQVAIKTCKANDDPEK 523
            ....||.||||||:.|.|..|:                       .| .:.|||||||.......
  Rat   509 LGRCIGEGQFGDVHQGVYLSPE-----------------------NP-ALAVAIKTCKNCTSDSV 549

  Fly   524 TENFLAEAYIMQKFDHPHIIRLIGICSVMPIWIVMELAKLGELRAYLKTNSERLSHGTLLKYCYQ 588
            .|.||.||..|::||||||::|||:.:..|:||:|||..|||||::|:.....|...:|:.|.||
  Rat   550 REKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQ 614

  Fly   589 LSTALSYLESKKFVHRDIAARNVLVSSPTCVKLADFGLSRWVSDQSYYHSTPTVALPIKWMSPES 653
            |||||:|||||:|||||||||||||||..||||.||||||::.|.:||.::.. .||||||:|||
  Rat   615 LSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKG-KLPIKWMAPES 678

  Fly   654 INFRRFTTASDVWMFGVCIWEILMLGVKPFQGVKNSDVILKLENGERLPLPPNCPPRLYSLMSQC 718
            |||||||:||||||||||:|||||.||||||||||:|||.::|||||||:||||||.|||||::|
  Rat   679 INFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKC 743

  Fly   719 WAYEPLKRPNFKRIKETLHEILIEDSINSSETLKREQRKVASMSWI--GSDDIDIPPSKPSRVMH 781
            |||:|.:||.|..:|..|..||.|:.:...|.::.|.|:.|::||.  |||:   .|.||||
  Rat   744 WAYDPSRRPRFTELKAQLSTILEEEKVQQEERMRMESRRQATVSWDSGGSDE---APPKPSR--- 802

  Fly   782 DPDITGLMPETTGLPQTYIIAQNPAVLAKLMMENQKRGINPAAYTTPASVFNTLAVGLDDSNPNV 846
                                                     ..|.:|.|
  Rat   803 -----------------------------------------PGYPSPRS---------------- 810

  Fly   847 SLKTTKLPAADLLKLDPIAESERLRSQFSANSSASQLANPLTASVNPHESLNSHQAGMFTGSLPS 911
                                ||                                      |..||
  Rat   811 --------------------SE--------------------------------------GFYPS 817

  Fly   912 KSSFVVCPPQTEEHMQAENISNPSVSKVSGYSLYGSLERHQPPPAKAMHSKGGSLERHQ-SLMSA 975
            ....|    ||..:            ::|||           |.:..:.:..||:...| ||:..
  Rat   818 PQHMV----QTNHY------------QISGY-----------PGSHGIPAMAGSIYPGQASLLDQ 855

  Fly   976 QNLVFYNTKPPPNCTNTAERSRSMERNTYFHAYRQQMKTSIECEALPEEIYDFGGIGLKTCVSAR 1040
            ..|  :|.:|                        |:|.
  Rat   856 TEL--WNHRP------------------------QEMS--------------------------- 867

  Fly  1041 QQPKFSPMVNVRPAELGQVQNTDCMGLQQNIPMDSFGVISPHNLDESL-RHQREME--RQWMTSG 1102
               .:.|.|....|       .|..|:.|.:|        ||.::|.| |.|:|||  ::|:..
  Rat   868 ---MWQPSVEDSAA-------LDLRGMGQVLP--------PHLMEERLIRQQQEMEEDQRWLEK- 913

  Fly  1103 PQSITVNPNISISEGAACLATLQAEAMGNQGIHNVLGEKLRQQQKDSNSDSEWLIQEELLRSCSI 1167
             :...:.|::.:|.|     ::..|....||
  Rat   914 -EERFLKPDVRLSRG-----SIDREDGSFQG---------------------------------- 938

  Fly  1168 PQGSLNDHQAQMFKLDFMSAGPSSLPDCSNSSSRPMTPNANLSSLKSNHSSADHLSSLTSAEEQM 1232
            |.|  |.|..|          |...||.:....:|..|.|      ..|.|  :|||::|..|..
  Rat   939 PTG--NQHIYQ----------PVGKPDPAAPPKKPPRPGA------PGHLS--NLSSISSPAESY 983

  Fly  1233 GSNAR--NLGSAVPSRPP----NRADDEVYCATTLVVKSIMALSQGVEKANTEGYLELVKNVGVK 1291
            ....:  .|.....|.||    :|::|:||...|.:||:::.:|..::.|..|.|:.:||.||:.
  Rat   984 NEGVKPWRLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLA 1048

  Fly  1292 LRNLLTSVDKISIIFPAQALKEVQMAHQVLSKDMHELVSAMRLAQQYSDTTLDCEYRKSMLSAAH 1356
            ||.||.:||:...|.||...:|::||.::|:.|:.||:|.|:|||||..|:|..||:|.||:|||
  Rat  1049 LRTLLATVDETIPILPASTHREIEMAQKLLNSDLGELISKMKLAQQYVMTSLQQEYKKQMLTAAH 1113

  Fly  1357 VLAMDAKNLFDVVDSIR 1373
            .||:|||||.||:|..|
  Rat  1114 ALAVDAKNLLDVIDQAR 1130

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fak	NP_001137718.1	B41	24..267	CDD:214604	61/218 (28%)
		FERM_B-lobe	152..257	CDD:271216	34/104 (33%)
		FERM_C_FAK1	263..394	CDD:270011	40/130 (31%)
		PTKc_FAK	450..744	CDD:133187	168/293 (57%)
		Pkinase_Tyr	462..736	CDD:285015	160/273 (59%)
		Focal_AT	1249..1376	CDD:281606	59/125 (47%)
Ptk2	XP_038934399.1	FERM_N_2	79..174	CDD:407875	19/90 (21%)
		B41	80..302	CDD:214604	61/218 (28%)
		FERM_C_FAK1	298..408	CDD:270011	40/136 (29%)
		PTKc_FAK	500..769	CDD:133187	168/293 (57%)
		Focal_AT	1004..1133	CDD:397606	59/127 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	324	1.000	Domainoid score	I1170
eggNOG	1	0.900	-	-		E1_KOG4257
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7314
Inparanoid	1	1.050	651	1.000	Inparanoid score	I754
OMA	1	1.010	-	-		QHG46813
OrthoDB	1	1.010	-	-		D29350at33208
OrthoFinder	1	1.000	-	-		FOG0002650
OrthoInspector	1	1.000	-	-		otm46241
orthoMCL	1	0.900	-	-		OOG6_105566
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1755
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.780