DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fak and ptk2bb

DIOPT Version :9

Sequence 1:	NP_001137718.1	Gene:	Fak / 37233	FlyBaseID:	FBgn0020440	Length:	1500	Species:	Drosophila melanogaster
Sequence 2:	NP_997735.1	Gene:	ptk2bb / 245950	ZFINID:	ZDB-GENE-020507-1	Length:	1004	Species:	Danio rerio

Alignment Length:	1374	Identity:	364/1374 - (26%)
Similarity:	553/1374 - (40%)	Gaps:	462/1374 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 NKSFKAVRFNVKETVFHVIRRTVEDLGTDGRT-PSIQRYAC---RMLNMITKEVIWLARSTSMQK 90
            :|:||.|:.:..    ..|:..::.:...||. |::|...|   |:.::.::|:.||...
Zfish    49 SKNFKLVKCDSS----WQIKTIIQSILISGRLGPNVQNPGCFGLRLKHLKSEELHWLHPD----- 104

  Fly    91 VLSHILTPGCSNVDCPNNQSELDEVLLEHGRRITDNRVWRVELRVRYVPNNIQELFEEDKATCFY 155
                 ||.|           |:::....|.....    ||.:||:||:|.:..:...||:....|
Zfish   105 -----LTVG-----------EVEQRYESHHAEAE----WRYDLRIRYIPIDYMKRLREDRTFLLY 149

  Fly   156 YFNQVKEDFIQANVTAIDTEVAVQLCCLGIRHYFKNITVKAPDKKQHIDYIEKEIGFKSFLPQSV 220
            ::.||:.|::|.:.:.:...:|:||.||.||.::|::..|..:||.:.|.:||::|...|.|:.:
Zfish   150 FYQQVRSDYMQHHASKVSDGMALQLGCLEIRRFYKDMNAKGLEKKSNFDLLEKDVGLDLFFPKGL 214

  Fly   221 IATSKPKNLKKLIQVGYKKVYNYNDIEYLTRFFDLLKNIYLTNFEQ--FSVTLSSAWNISGILHV 283
            |.:.|.:.|:||||..:::.....:.:.:.:||:....  .:||::  |...|...|:::..|.:
Zfish   215 IDSMKQRQLRKLIQQTFQQYAILKEDDCMVKFFETYGE--FSNFDEEIFPCELVQGWSLAVDLVI 277

  Fly   284 GPHIGISYQTHPQASLKNVAQFKDVVSIKTCTLPKEKLSKSGENTTEPELQNFNCNCQKI-KTQI 347
            ||. ||..:|...::...:|::|.:.|||                         .|.|.. :|.:
Zfish   278 GPK-GIRQRTKADSTALCLAEYKQIRSIK-------------------------YNAQNDGRTLL 316

  Fly   348 KISASNNVEDLVITCNGINTAESIADLIDGYCRLLSKDLEFTIWHRETNA-----SNEDSAKALP 407
            .|......:.|.::...:..||::||||||||||.:        |.:::.     .|:.....|.
Zfish   317 FIEIDGAKQPLSVSVASLTIAENMADLIDGYCRLFN--------HTDSSVIAGPNKNKSQGVQLR 373

  Fly   408 ND-ATLGSNKSTSSQGKPMLTDDYAEIGLLEGEGDYSTPTVRNYELDRALITPSAKIGVGQFGDV 471
            |. ..:.|.|.|.| .:...:|.|.||      .|...|......|.|..|:....:|.|.||:|
Zfish   374 NSLPEIPSGKKTDS-FRYSNSDIYCEI------PDEKPPPPAKVGLSRKDISLKRMLGEGFFGEV 431

  Fly   472 YVGTYTLPKLGKGKNLAGNGKNSNSDQRNADSRPDVIQVAIKTCKANDDPEKTENFLAEAYIMQK 536
            :.|.|                    .::|.:.    :.||:|||| ...|:..|.|:.||.||:.
Zfish   432 HEGVY--------------------QKKNGEK----VNVAVKTCK-ECAPDIREKFVGEAVIMKN 471

  Fly   537 FDHPHIIRLIGICSVMPIWIVMELAKLGELRAYLKTNSERLSHGTLLKYCYQLSTALSYLESKKF 601
            .|||||:||||:....|:||||||.:.|||..||..|.:.|:..||:.:..||..||.||:....
Zfish   472 LDHPHIVRLIGVIEEDPVWIVMELCQQGELGKYLTKNQQSLTSVTLVLFSLQLCKALVYLQGMNM 536

  Fly   602 VHRDIAARNVLVSSPTCVKLADFGLSRWVSDQSYYHSTPTVALPIKWMSPESINFRRFTTASDVW 666
            ||||||.|||||::|.||||.||||||::.|:.||.::.| .||||||:||||||||||.|||||
Zfish   537 VHRDIAVRNVLVATPECVKLGDFGLSRYIEDEEYYKASVT-RLPIKWMAPESINFRRFTAASDVW 600

  Fly   667 MFGVCIWEILMLGVKPFQGVKNSDVILKLENGERLPLPPNCPPRLYSLMSQCWAYEPLKRPNFKR 731
            ||.||:|||:..|.:||..:.|.|||.:||.|.|||.|..|||.|||||::||:|:|.:||.|..
Zfish   601 MFAVCVWEIMNRGKQPFHWLDNRDVINQLEQGNRLPKPEQCPPALYSLMTRCWSYDPRERPTFTE 665

  Fly   732 IKETLHEI-LIEDSINSSETLKREQRKVASMSWIGSD-DIDIPPSKPSRVMHDPDITGLMPETTG 794
            :...:.:: .:|..:.:    :||:.|..::..:... :|..||.|||||           .||.
Zfish   666 LACNISDVHQMEKELEA----ERERDKARNIRTLEPKINISEPPPKPSRV-----------NTTR 715

  Fly   795 LPQTYIIAQNPAVLAKLMMENQKRGINPAAYTTPASVFNTLAVGLDDSNPNVSLKTTKLPAADLL 859
            ..                                    |||.|||
Zfish   716 FG------------------------------------NTLGVGL-------------------- 724

  Fly   860 KLDPIAESERLRSQFSANSSASQLANPLTASVNPHESLNSHQAGMFTGSLPSKSSFVVCPPQTEE 924
                                              |..||.                .:|
Zfish   725 ----------------------------------HLQLNE----------------ALC------ 733

  Fly   925 HMQAENISNPSVSKVSGYSLYGSLERHQPPPAKAMHSKGGSLERHQSLMSAQNLVFYNTKPPPNC 989
                  .|:|.::....|                           ||.:.:.||:        :.
Zfish   734 ------ASSPDLASPCDY---------------------------QSPVDSTNLL--------SL 757

  Fly   990 TNTAERSRSMERNTYFHAYRQQMKTSIECEALPEEIYDFGGIGLKTCVSARQQPKFSPMVNVRPA 1054
            ..|..|..|:...                        ||
Zfish   758 PKTPNRRLSLGEG------------------------DF-------------------------- 772

  Fly  1055 ELGQVQNTDCMGLQQNIPMDSFGVISPHNLDESLR-HQREMERQWMTSGPQSITVNPNISISEGA 1118
                                |||   |.:.:::.| .|.|.:|
Zfish   773 --------------------SFG---PSSKEDAQRLWQMEKDR---------------------- 792

  Fly  1119 ACLATLQAEAMGNQGIHNVLGEKLRQQQKDSNSDSEWLIQEELLRSCSIPQGSLNDHQAQMFKLD 1183
                               |.:.|:.|::....|::||.:||.|....:.:||         |:
Zfish   793 -------------------LQDTLKMQKEQMEEDTKWLKKEEKLLDPMVHEGS---------KI- 828

  Fly  1184 FMSAGPSSLPDCSNSSSRPMTPNANLSSLKSNHSSADHLSSLTSAEEQMGSNARNLGSAVPSRPP 1248
                              |..|...||..:.:|.                          ||:||
Zfish   829 ------------------PEPPEPPLSYAELHHP--------------------------PSKPP 849

  Fly  1249 ------------NRADDEVYCATTLVVKSIMALSQGVEKANTEGYLELVKNVGVKLRNLLTSVDK 1301
                        :|::|.||.....|||.::.|...:...::..|:..||.||:.||:|:.|||.
Zfish   850 RIAVQPAPTAELDRSEDTVYQCVMDVVKVVVQLKNDINTLSSTEYISPVKTVGLSLRDLINSVDD 914

  Fly  1302 ISIIFPAQALKEVQMAHQVLSKDMHELVSAMRLAQQYSDTTLDCEYRKSMLSAAHVLAMDAKNLF 1366
            |..........|::...::|:||:.||:|.||||||.:.|:|..|.:|.||:|||.||||||||.
Zfish   915 ILPTLHISCRTEIEGTQKLLNKDLAELISKMRLAQQNAITSLKEECKKQMLTAAHTLAMDAKNLL 979

  Fly  1367 DVVDSIRQR 1375
            |.||..|.|
Zfish   980 DAVDQARVR 988

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fak	NP_001137718.1	B41	24..267	CDD:214604	61/242 (25%)
		FERM_B-lobe	152..257	CDD:271216	31/104 (30%)
		FERM_C_FAK1	263..394	CDD:270011	34/133 (26%)
		PTKc_FAK	450..744	CDD:133187	139/294 (47%)
		Pkinase_Tyr	462..736	CDD:285015	135/273 (49%)
		Focal_AT	1249..1376	CDD:281606	55/127 (43%)
ptk2bb	NP_997735.1	B41	38..261	CDD:214604	61/242 (25%)
		FERM_B-lobe	149..249	CDD:271216	31/99 (31%)
		FERM_C_FAK1	257..364	CDD:270011	32/140 (23%)
		PTKc_FAK	410..678	CDD:133187	138/293 (47%)
		Pkinase_Tyr	417..670	CDD:285015	136/278 (49%)
		Focal_AT	860..989	CDD:281606	55/129 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	115	1.000	Domainoid score	I5966
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	628	1.000	Inparanoid score	I834
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D29350at33208
OrthoFinder	1	1.000	-	-		FOG0002650
OrthoInspector	1	1.000	-	-		otm26029
orthoMCL	1	0.900	-	-		OOG6_105566
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4950
SonicParanoid	1	1.000	-	-		X1755
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.900