Protein Alignment Fak and Jak2

DIOPT Version :10

• Sequence 1: NP_001137718.1
• Gene: Fak / 37233
• FlyBaseID: FBgn0020440
• Length: 1500
• Species: Drosophila melanogaster
• Sequence 2: NP_113702.1
• Gene: Jak2 / 24514
• RGDID: 2939
• Length: 1132
• Species: Rattus norvegicus
• Alignment Length: 748
• Identity: 170/748 - (22%)
• Similarity: 276/748 - (36%)
• Gaps: 223/748 - (29%)

  Fly   105 CPNNQSELDEVLLEHGRRITDNRVWRVELRVRYVP-----NNIQELFEEDKATCFYYFNQVK-ED 163
            ||....:...:|:.....::|         |:..|     ||:.::          .|:::: ||
  Rat   499 CPPKPKDKSNLLVFRTNGVSD---------VQLSPTLQRHNNVNQM----------VFHKIRNED 544

  Fly   164 FI------QANVTAIDTEVAVQLCCLGIRHYFKNITVKAPDKKQHIDYIE---------KEIGFK 213
            .|      |...|.|...|..::...|..|. ..:.:|..| |.|.:|.|         .::..|
  Rat   545 LIFNESLGQGTFTKIFKGVRREVGDYGQLHE-TEVLLKVLD-KAHRNYSESFFEAASMMSQLSHK 607

  Fly   214 SFLPQSVIATSKPKNL--KKLIQVGYKKVY---NYNDIEYLTRFFDLLKNIYLTNFEQFSVTLSS 273
            ..:....:.....:|:  ::.::.|....|   |.|.|..|.:               ..|....
  Rat   608 HLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSINILWK---------------LGVAKQL 657

  Fly   274 AWNISGILHVGPHIGISYQTHPQASLKNVAQFKDVVSIKTCTLPKEKLSKSGENTTEPELQNFNC 338
            ||    .:|......:   .|.....||:...:: ...||...|..|||..|.:.|
  Rat   658 AW----AMHFLEEKSL---IHGNVCAKNILLIRE-EDRKTGNPPFIKLSDPGISIT--------- 705

  Fly   339 NCQKIKTQIKISASNNVEDLVITCNGINTAESIADLIDGYCRLLSKDL--EFTIWHRETNASNED 401
                                                      :|.||:  |...|.......|
  Rat   706 ------------------------------------------VLPKDILQERIPWVPPECIEN-- 726

  Fly   402 SAKALPNDATLGSNKST---------SSQGKPM-LTDDYAEIGLLEGEGDYSTP----------T 446
                 |.:.||.::|.:         |...||: ..|...::...|.:.....|          |
  Rat   727 -----PKNLTLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDKHQLPAPKWTELANLINT 786

  Fly   447 VRNYELD-----RALI-------------------TPSAKIGV----GQFGDVYVGTYT------ 477
            ..:||.|     ||:|                   .|:.:||.    |.|.|.....:.
  Rat   787 CMDYEPDFRPAFRAVIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKF 851

  Fly   478 LPKLGKGKNLAGNGKNSNSDQRNADSRPDVIQ------VAIKTCKANDDPEKTENFLAEAYIMQK 536
            |.:||||        |..|.:.   .|.|.:|      ||:|..:.:.: |...:|..|..|::.
  Rat   852 LQQLGKG--------NFGSVEM---CRYDPLQDNTGEVVAVKKLQHSTE-EHLRDFEREIEILKS 904

  Fly   537 FDHPHIIRLIGIC---SVMPIWIVMELAKLGELRAYLKTNSERLSHGTLLKYCYQLSTALSYLES 598
            ..|.:|::..|:|   ....:.::||....|.||.||:.:.||:.|..||:|..|:...:.||.:
  Rat   905 LQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQICKGMEYLGT 969

  Fly   599 KKFVHRDIAARNVLVSSPTCVKLADFGLSRWV-SDQSYYHSTPTVALPIKWMSPESINFRRFTTA 662
            |:::|||:|.||:||.:...||:.||||::.: .|:.||........||.|.:|||:...:|:.|
  Rat   970 KRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVA 1034

  Fly   663 SDVWMFGVCIWEILMLGVK------PFQGVKNSD---------VILKLENGERLPLPPNCPPRLY 712
            ||||.|||.::|:.....|      .|..:..:|         :|..|:|..|||.|..||..:|
  Rat  1035 SDVWSFGVVLYELFTYIEKSKSPPVEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPEGCPDEIY 1099

  Fly   713 SLMSQCWAYEPLKRPNFKRIKETLHEILIEDSI 745
            .:|::||.....:||:|:.:  :|....|.||:
  Rat  1100 VIMTECWNNNVNQRPSFRDL--SLRVDQIRDSM 1130

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fak	NP_001137718.1	B41	24..267	CDD:214604	32/187 (17%)
		FERM_B-lobe	152..257	CDD:271216	24/125 (19%)
		FERM_C_FAK1	263..394	CDD:270011	20/132 (15%)
		PTKc_FAK	450..744	CDD:133187	104/352 (30%)
		Focal_AT	1250..1376	CDD:460992
Jak2	NP_113702.1	Interaction with cytokine/interferon/growth hormone receptors. /evidence=ECO:0000250	1..239
		FERM_F1	39..134	CDD:465733
		FERM_F2	143..261	CDD:436450
		FERM_C_JAK2	266..386	CDD:270141
		SH2_Jak2	386..482	CDD:198242
		PTK_Jak2_rpt1	545..806	CDD:270663	59/343 (17%)
		PTKc_Jak2_rpt2	844..1127	CDD:271107	91/296 (31%)