DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fak and PTK2B

DIOPT Version :9

Sequence 1:	NP_001137718.1	Gene:	Fak / 37233	FlyBaseID:	FBgn0020440	Length:	1500	Species:	Drosophila melanogaster
Sequence 2:	NP_004094.3	Gene:	PTK2B / 2185	HGNCID:	9612	Length:	1009	Species:	Homo sapiens

Alignment Length:	1371	Identity:	373/1371 - (27%)
Similarity:	565/1371 - (41%)	Gaps:	430/1371 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 PNKSFKAVRFNVKETVFHVIRRTVEDLGTDGRT-PSI---QRYACRMLNMITKEVIWLARSTSMQ 89
            |.|:||.    ||.||...||..:..:...||. |:|   :.|..|:.:|.:.|:.||....::.
Human    52 PGKNFKL----VKCTVQTEIREIITSILLSGRIGPNIRLAECYGLRLKHMKSDEIHWLHPQMTVG 112

  Fly    90 KVLSHILTPGCSNVDCPNNQSELDEVLLEHGRRITDNRVWRVELRVRYVPNNIQELFEEDKATCF 154
            :|.        ...:|.:.::|                 ||.:|::||:|.:..|..:||:.|..
Human   113 EVQ--------DKYECLHVEAE-----------------WRYDLQIRYLPEDFMESLKEDRTTLL 152

  Fly   155 YYFNQVKEDFIQANVTAIDTEVAVQLCCLGIRHYFKNITVKAPDKKQHIDYIEKEIGFKSFLPQS 219
            |::.|::.|::|...:.:...:|:||.||.:|.:||::...|.|||.:.:.:|||:|...|.|:.
Human   153 YFYQQLRNDYMQRYASKVSEGMALQLGCLELRRFFKDMPHNALDKKSNFELLEKEVGLDLFFPKQ 217

  Fly   220 VIATSKPKNLKKLIQVGYKKVYNYNDIEYLTRFFDLLKNIYLTNFEQFSVTLSSAWNISGILHVG 284
            :....|||..:|:||..:::..:..:.|.:.:||:.|......:.|.:...|...|||:..|.:|
Human   218 MQENLKPKQFRKMIQQTFQQYASLREEECVMKFFNTLAGFANIDQETYRCELIQGWNITVDLVIG 282

  Fly   285 PHIGISYQTHPQASLKNVAQFKDVVSIKTCTLPKEKLSKSGENTTEPELQNFNCNCQKIKTQIKI 349
            |. ||...|...|....:|:||.:.||: | ||.|:    |:                  ..:::
Human   283 PK-GIRQLTSQDAKPTCLAEFKQIRSIR-C-LPLEE----GQ------------------AVLQL 322

  Fly   350 SASNNVEDLVITCNGINTAESIADLIDGYCRLLSKDLEFTIWHRETNASNEDSAKALPNDATLGS 414
            ......:.|.|..:.:..||::||||||||||..:.....|.|...:....:|...:|. ..|.:
Human   323 GIEGAPQALSIKTSSLAEAENMADLIDGYCRLQGEHQGSLIIHPRKDGEKRNSLPQIPM-LNLEA 386

  Fly   415 NKSTSSQGKPMLTDDYAEIGLLEGEGDYSTPTVRNYELDRALITPSAKIGVGQFGDVYVGTYTLP 479
            .:|..|:...:.:|.||||    .:.....|....|.:.|..:..:..:|.|.||:||.|.||
Human   387 RRSHLSESCSIESDIYAEI----PDETLRRPGGPQYGIAREDVVLNRILGEGFFGEVYEGVYT-- 445

  Fly   480 KLGKGKNLAGNGKNSNSDQRNADSRPDVIQVAIKTCKANDDPEKTENFLAEAYIMQKFDHPHIIR 544
                                  :.:.:.|.||:||||.:...:..|.|::||.||:..|||||::
Human   446 ----------------------NHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHIVK 488

  Fly   545 LIGICSVMPIWIVMELAKLGELRAYLKTNSERLSHGTLLKYCYQLSTALSYLESKKFVHRDIAAR 609
            ||||....|.||:|||...|||..||:.|...|...||:.|..|:..|::||||...||||||.|
Human   489 LIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVR 553

  Fly   610 NVLVSSPTCVKLADFGLSRWVSDQSYYHSTPTVALPIKWMSPESINFRRFTTASDVWMFGVCIWE 674
            |:||:||.||||.||||||::.|:.||.::.| .|||||||||||||||||||||||||.||:||
Human   554 NILVASPECVKLGDFGLSRYIEDEDYYKASVT-RLPIKWMSPESINFRRFTTASDVWMFAVCMWE 617

  Fly   675 ILMLGVKPFQGVKNSDVILKLENGERLPLPPNCPPRLYSLMSQCWAYEPLKRPNFKRIKETLHEI 739
            ||..|.:||..::|.|||..||.|:|||.|..|||.||:||::||.|:|..||.|..:..:|
Human   618 ILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDPSDRPRFTELVCSL--- 679

  Fly   740 LIEDSINSSETLKREQRKVA---SMSWIGSDDIDIPPSKPSRVMHDPDITGLMPETTGLPQTYII 801
              .|.....:.:..||.:.|   :...:.......||.||||..:.|.           |||.::
Human   680 --SDVYQMEKDIAMEQERNARYRTPKILEPTAFQEPPPKPSRPKYRPP-----------PQTNLL 731

  Fly   802 AQNPAVLAKLMMENQKRGINPAAYTTPASVFNTLAVGLDDSNPNVSLKTTKLPAADLLKLDPIAE 866
            |      .||..:                    :..||..|:|.
Human   732 A------PKLQFQ--------------------VPEGLCASSPT--------------------- 749

  Fly   867 SERLRSQFSANSSASQLANPLTASVNPHESLNSHQAGMFTGSLPSKSSFVVCPPQTEEHMQAENI 931
                            |.:|:
Human   750 ----------------LTSPM-------------------------------------------- 754

  Fly   932 SNPSVSKVSGYSLYGSLERHQPPPAKAMHSKGGSLERHQSLMSAQNLVFYNTKPPPNCTNTAERS 996
                               ..|.|..::|:                       ||.:..|..:|
Human   755 -------------------EYPSPVNSLHT-----------------------PPLHRHNVFKR- 776

  Fly   997 RSMERNTYFHAYRQQMKTSIECEALPEEIYDFGGIGLKTCVSARQQPKFSPMVNVRPAELGQVQN 1061
                     |:.|::               ||                      ::|:.
Human   777 ---------HSMREE---------------DF----------------------IQPSS------ 789

  Fly  1062 TDCMGLQQNIPMDSFGVISPHNLDESLRHQREMERQWMTSGPQSITVNPNISISEGAACLATLQA 1126
                                         :.|.::.|                          :|
Human   790 -----------------------------REEAQQLW--------------------------EA 799

  Fly  1127 EAMGNQGIHNVLGEKLRQ----QQKDSNSDSEWLIQEELLRSCSIPQGSLNDH-----QAQMFKL 1182
            |.:           |:||    |||....|.:||.|||  :|.. |...:||.     :.::..|
Human   800 EKV-----------KMRQILDKQQKQMVEDYQWLRQEE--KSLD-PMVYMNDKSPLTPEKEVGYL 850

  Fly  1183 DFMSAGPSSLPDCSNSSSRPMTPNANLSSLKSNHSSADHLSSLTSAEEQMGSNARNLGSAVPSRP 1247
            :|  .||...|....:.|  :.|.|||
Human   851 EF--TGPPQKPPRLGAQS--IQPTANL-------------------------------------- 873

  Fly  1248 PNRADDEVYCATTLVVKSIMALSQGVEKANTEGYLELVKNVGVKLRNLLTSVDKISIIFPAQALK 1312
             :|.||.||.....:|::::.|...:.:...|||:.:|||||:.||.|:.|||.:....|:.:..
Human   874 -DRTDDLVYLNVMELVRAVLELKNELCQLPPEGYVVVVKNVGLTLRKLIGSVDDLLPSLPSSSRT 937

  Fly  1313 EVQMAHQVLSKDMHELVSAMRLAQQYSDTTLDCEYRKSMLSAAHVLAMDAKNLFDVVDSIRQRYQ 1377
            |::...::|:||:.||::.||||||.:.|:|..|.::.||:|:|.||:|||||.|.||..:....
Human   938 EIEGTQKLLNKDLAELINKMRLAQQNAVTSLSEECKRQMLTASHTLAVDAKNLLDAVDQAKVLAN 1002

  Fly  1378 HLFPPS 1383
            ...||:
Human  1003 LAHPPA 1008

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fak	NP_001137718.1	B41	24..267	CDD:214604	66/241 (27%)
		FERM_B-lobe	152..257	CDD:271216	32/104 (31%)
		FERM_C_FAK1	263..394	CDD:270011	38/130 (29%)
		PTKc_FAK	450..744	CDD:133187	141/293 (48%)
		Pkinase_Tyr	462..736	CDD:285015	138/273 (51%)
		Focal_AT	1249..1376	CDD:281606	51/126 (40%)
PTK2B	NP_004094.3	B41	41..254	CDD:214604	64/230 (28%)
		FERM_B-lobe	150..254	CDD:271216	32/103 (31%)
		FERM_C_FAK1	261..368	CDD:270011	38/131 (29%)
		PTKc_FAK	418..687	CDD:133187	142/298 (48%)
		TyrKc	425..679	CDD:197581	138/278 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	701..725		6/23 (26%)
		Interaction with TGFB1I1. /evidence=ECO:0000250	801..1009		79/265 (30%)
		Focal adhesion targeting (FAT)	868..1009		57/180 (32%)
		Focal_AT	872..1001	CDD:281606	53/167 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	116	1.000	Domainoid score	I5959
eggNOG	1	0.900	-	-		E1_KOG4257
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	646	1.000	Inparanoid score	I803
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D29350at33208
OrthoFinder	1	1.000	-	-		FOG0002650
OrthoInspector	1	1.000	-	-		otm42092
orthoMCL	1	0.900	-	-		OOG6_105566
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4950
SonicParanoid	1	1.000	-	-		X1755
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.760