Protein Alignment Fak and Src

DIOPT Version :10

• Sequence 1: NP_001137718.1
• Gene: Fak / 37233
• FlyBaseID: FBgn0020440
• Length: 1500
• Species: Drosophila melanogaster
• Sequence 2: XP_006499126.1
• Gene: Src / 20779
• MGIID: 98397
• Length: 552
• Species: Mus musculus
• Alignment Length: 302
• Identity: 104/302 - (34%)
• Similarity: 157/302 - (51%)
• Gaps: 39/302 - (12%)

  Fly   450 YELDRALITPSAKIGVGQFGDVYVGTYTLPKLGKGKNLAGNGKNSNSDQRNADSRPDVIQVAIKT 514
            :|:.|..:....|:|.|.||:|::||:             ||               ..:|||||
Mouse   279 WEIPRESLRLEVKLGQGCFGEVWMGTW-------------NG---------------TTRVAIKT 315

  Fly   515 CKAND-DPEKTENFLAEAYIMQKFDHPHIIRLIGICSVMPIWIVMELAKLGELRAYLKTNSER-L 577
            .|... .||.   ||.||.:|:|..|..:::|..:.|..||:||.|....|.|..:||..:.: |
Mouse   316 LKPGTMSPEA---FLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKGETGKYL 377

  Fly   578 SHGTLLKYCYQLSTALSYLESKKFVHRDIAARNVLVSSPTCVKLADFGLSRWVSDQSYYHSTPTV 642
            ....|:....|:::.::|:|...:||||:.|.|:||......|:|||||:|.:.|.. |.:....
Mouse   378 RLPQLVDMSAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNE-YTARQGA 441

  Fly   643 ALPIKWMSPESINFRRFTTASDVWMFGVCIWEILMLGVKPFQGVKNSDVILKLENGERLPLPPNC 707
            ..||||.:||:..:.|||..||||.||:.:.|:...|..|:.|:.|.:|:.::|.|.|:|.||.|
Mouse   442 KFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPEC 506

  Fly   708 PPRLYSLMSQCWAYEPLKRPNFKRIKETLHEILIEDSINSSE 749
            |..|:.||.|||..||.:||.|:.:     :..:||...|:|
Mouse   507 PESLHDLMCQCWRKEPEERPTFEYL-----QAFLEDYFTSTE 543

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fak	NP_001137718.1	B41	24..267	CDD:214604
		FERM_B-lobe	152..257	CDD:271216
		FERM_C_FAK1	263..394	CDD:270011
		PTKc_FAK	450..744	CDD:133187	101/295 (34%)
		Focal_AT	1250..1376	CDD:460992
Src	XP_006499126.1	SH3_Src	87..159	CDD:212941
		SH2_Src_Src	163..263	CDD:198228
		PTKc_Src	276..552	CDD:270656	104/302 (34%)