Protein Alignment Fak and Ptk2b

DIOPT Version :10

• Sequence 1: NP_001137718.1
• Gene: Fak / 37233
• FlyBaseID: FBgn0020440
• Length: 1500
• Species: Drosophila melanogaster
• Sequence 2: XP_017171415.1
• Gene: Ptk2b / 19229
• MGIID: 104908
• Length: 1020
• Species: Mus musculus
• Alignment Length: 1375
• Identity: 370/1375 - (26%)
• Similarity: 567/1375 - (41%)
• Gaps: 427/1375 - (31%)

  Fly    29 PNKSFKAVRFNVKETVFHVIRRTVEDLGTDGRT-PSIQR---YACRMLNMITKEVIWLARSTSMQ 89
            |.|:||.|:..|:..:..:|...:    ..||. |:||.   |..|:.:|.:.|:.||....::.
Mouse    52 PGKNFKLVKCTVQTEIQEIITSIL----LSGRIGPNIQLAECYGLRLKHMKSDEIHWLHPQMTVG 112

  Fly    90 KVLSHILTPGCSNVDCPNNQSELDEVLLEHGRRITDNRVWRVELRVRYVPNNIQELFEEDKATCF 154
            :|.        ...:|.:.::|                 ||.:|::||:|.:..|..:||:.|..
Mouse   113 EVQ--------DKYECLHVEAE-----------------WRYDLQIRYLPEDFMESLKEDRTTLL 152

  Fly   155 YYFNQVKEDFIQANVTAIDTEVAVQLCCLGIRHYFKNITVKAPDKKQHIDYIEKEIGFKSFLPQS 219
            |::.|::.|::|...:.:...:|:||.||.:|.:||::...|.|||.:.:.:|||:|...|.|:.
Mouse   153 YFYQQLRNDYMQRYASKVSEGMALQLGCLELRRFFKDMPHNALDKKSNFELLEKEVGLDLFFPKQ 217

  Fly   220 VIATSKPKNLKKLIQVGYKKVYNYNDIEYLTRFFDLLKNIYLTNFEQFSVTLSSAWNISGILHVG 284
            :....|||..:|:||..:::..:..:.|.:.:||:.|......:.|.:...|...|||:..|.:|
Mouse   218 MQENLKPKQFRKMIQQTFQQYASLREEECVMKFFNTLAGFANIDQETYRCELIQGWNITVDLVIG 282

  Fly   285 PHIGISYQTHPQASLKNVAQFKDVVSIKTCTLPKEKLSKSGENTTEPELQNFNCNCQKIKTQIKI 349
            |. ||...|........:|:||.:.||: | ||.|:        |:..||              :
Mouse   283 PK-GIRQLTSQDTKPTCLAEFKQIKSIR-C-LPLEE--------TQAVLQ--------------L 322

  Fly   350 SASNNVEDLVITCNGINTAESIADLIDGYCRLLSKDLEFTIWHRETNASNEDSAKALPNDATLGS 414
            ......:.|.|..:.:..||::||||||||||..:.....|.|.:.:....:|...:|. ..|.:
Mouse   323 GIEGAPQSLSIKTSSLAEAENMADLIDGYCRLQGEHKGSLIMHAKKDGEKRNSLPQIPT-LNLEA 386

  Fly   415 NKSTSSQGKPMLTDDYAEIGLLEGEGDYSTPTVRNYELDRALITPSAKIGVGQFGDVYVGTYTLP 479
            .:|..|:...:.:|.||||    .:.....|....|.:.|..:..:..:|.|.||:||.|.||
Mouse   387 RRSHLSESCSIESDIYAEI----PDETLRRPGGPQYGVAREEVVLNRILGEGFFGEVYEGVYT-- 445

  Fly   480 KLGKGKNLAGNGKNSNSDQRNADSRPDVIQVAIKTCKANDDPEKTENFLAEAYIMQKFDHPHIIR 544
                                  :.:.:.|.||:||||.:...:..|.|::||.||:..|||||::
Mouse   446 ----------------------NHKGEKINVAVKTCKKDCTQDNKEKFMSEAVIMKNLDHPHIVK 488

  Fly   545 LIGICSVMPIWIVMELAKLGELRAYLKTNSERLSHGTLLKYCYQLSTALSYLESKKFVHRDIAAR 609
            ||||....|.||:|||...|||..||:.|...|...||:.|..|:..|::||||...||||||.|
Mouse   489 LIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVPTLVLYTLQICKAMAYLESINCVHRDIAVR 553

  Fly   610 NVLVSSPTCVKLADFGLSRWVSDQSYYHSTPTVALPIKWMSPESINFRRFTTASDVWMFGVCIWE 674
            |:||:||.||||.||||||::.|:.||.::.| .|||||||||||||||||||||||||.||:||
Mouse   554 NILVASPECVKLGDFGLSRYIEDEDYYKASVT-RLPIKWMSPESINFRRFTTASDVWMFAVCMWE 617

  Fly   675 ILMLGVKPFQGVKNSDVILKLENGERLPLPPNCPPRLYSLMSQCWAYEPLKRPNFKRIKETLHEI 739
            ||..|.:||..::|.|||..||.|:|||.|..|||.||:||::||.|:|..||.|..:..:|.:|
Mouse   618 ILSFGKQPFFWLENKDVIGVLEKGDRLPKPELCPPVLYTLMTRCWDYDPSDRPRFTELVCSLSDI 682

  Fly   740 --LIED-SINSSETLKREQRKVASMSWIGSDDIDIPPSKPSRVMHDPDITGLMPETTGLPQTYII 801
              :.:| :|......:....|:     :.......||.||||..:.|.           |||.::
Mouse   683 YQMEKDIAIEQERNARYRPPKI-----LEPTTFQEPPPKPSRPKYRPP-----------PQTNLL 731

  Fly   802 AQNPAVLAKLMMENQKRGINPAAYTTPASVFNTLAVGLDDSNPNVSLKTTKLPAADLLKLDPIAE 866
            |      .||..:                    :..||..|:|.
Mouse   732 A------PKLQFQ--------------------VPEGLCASSPT--------------------- 749

  Fly   867 SERLRSQFSANSSASQLANPLTASVNPHESLNSHQAGMFTGSLPSKSSFVVCPPQTEEHMQAENI 931
                            |.:|:
Mouse   750 ----------------LTSPM-------------------------------------------- 754

  Fly   932 SNPSVSKVSGYSLYGSLERHQPPPAKAMHSKGGSLERHQSLMSAQNLVFYNTKPPPNCTNTAERS 996
                               ..|.|..::|:                       ||.:..|..:|
Mouse   755 -------------------EYPSPVNSLHT-----------------------PPLHRHNVFKR- 776

  Fly   997 RSMERNTYFHAYRQQMKTSIECEALPEEIYDFGGIGLKTCVSARQQPKFSPMVNVRPAELGQVQN 1061
                     |:.|::               ||                      :||:.
Mouse   777 ---------HSMREE---------------DF----------------------IRPSS------ 789

  Fly  1062 TDCMGLQQNIPMDSFGVISPHNLDESLRHQREMERQWMTSGPQSITVNPNISISEGAACLATLQA 1126
                                         :.|.::.|                          :|
Mouse   790 -----------------------------REEAQQLW--------------------------EA 799

  Fly  1127 EAMGNQGIHNVLGEKLRQQQKDSNSDSEWLIQEELLRSCSIPQGSLNDHQAQMFKLDFMSAGPSS 1191
            |.:       .:.:.|.:|||....||:||.:||   .|..|...:||
Mouse   800 EKI-------KMKQVLERQQKQMVEDSQWLRREE---RCLDPMVYMND----------------- 837

  Fly  1192 LPDCSNSSSRPMTPNANLSSLKSNHSSADHLSSLTSAEEQMGSNARNLGSAVPSRPP-------- 1248
                    ..|:||.      |....|...|.::::..|..|.         |.:||
Mouse   838 --------KSPLTPE------KEAGYSECFLGTVSARAEFTGP---------PQKPPRLGAQSIQ 879

  Fly  1249 -----NRADDEVYCATTLVVKSIMALSQGVEKANTEGYLELVKNVGVKLRNLLTSVDKISIIFPA 1308
                 :|.||.||.....:|::::.|...:.:...|.|:.:|||||:.||.|:.|||.:....||
Mouse   880 PTANLDRTDDLVYHNVMTLVEAVLELKNKLGQLPPEDYVVVVKNVGLNLRKLIGSVDDLLPSLPA 944

  Fly  1309 QALKEVQMAHQVLSKDMHELVSAMRLAQQYSDTTLDCEYRKSMLSAAHVLAMDAKNLFDVVDSIR 1373
            .:..|::...::|:||:.||::.|:||||.:.|:|..:.::.||:|:|.||:|||||.|.||..:
Mouse   945 SSRTEIEGTQKLLNKDLAELINKMKLAQQNAVTSLSEDCKRQMLTASHTLAVDAKNLLDAVDQAK 1009

  Fly  1374 QRYQHLFPPS 1383
            .......||:
Mouse  1010 VVANLAHPPA 1019

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fak	NP_001137718.1	B41	24..267	CDD:214604	64/241 (27%)
		FERM_B-lobe	152..257	CDD:271216	32/104 (31%)
		FERM_C_FAK1	263..394	CDD:270011	39/130 (30%)
		PTKc_FAK	450..744	CDD:133187	143/296 (48%)
		Focal_AT	1250..1376	CDD:460992	49/125 (39%)
Ptk2b	XP_017171415.1	FERM_N_2	39..137	CDD:436229	26/113 (23%)
		B41	41..254	CDD:214604	62/230 (27%)
		FERM_C_FAK1	261..368	CDD:270011	39/131 (30%)
		PTKc_FAK	418..687	CDD:133187	142/293 (48%)
		Focal_AT	883..1012	CDD:460992	49/128 (38%)