DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Fak and Ptk2b

DIOPT Version :9

Sequence 1:NP_001137718.1 Gene:Fak / 37233 FlyBaseID:FBgn0020440 Length:1500 Species:Drosophila melanogaster
Sequence 2:XP_017171415.1 Gene:Ptk2b / 19229 MGIID:104908 Length:1020 Species:Mus musculus


Alignment Length:1375 Identity:370/1375 - (26%)
Similarity:567/1375 - (41%) Gaps:427/1375 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 PNKSFKAVRFNVKETVFHVIRRTVEDLGTDGRT-PSIQR---YACRMLNMITKEVIWLARSTSMQ 89
            |.|:||.|:..|:..:..:|...:    ..||. |:||.   |..|:.:|.:.|:.||....::.
Mouse    52 PGKNFKLVKCTVQTEIQEIITSIL----LSGRIGPNIQLAECYGLRLKHMKSDEIHWLHPQMTVG 112

  Fly    90 KVLSHILTPGCSNVDCPNNQSELDEVLLEHGRRITDNRVWRVELRVRYVPNNIQELFEEDKATCF 154
            :|.        ...:|.:.::|                 ||.:|::||:|.:..|..:||:.|..
Mouse   113 EVQ--------DKYECLHVEAE-----------------WRYDLQIRYLPEDFMESLKEDRTTLL 152

  Fly   155 YYFNQVKEDFIQANVTAIDTEVAVQLCCLGIRHYFKNITVKAPDKKQHIDYIEKEIGFKSFLPQS 219
            |::.|::.|::|...:.:...:|:||.||.:|.:||::...|.|||.:.:.:|||:|...|.|:.
Mouse   153 YFYQQLRNDYMQRYASKVSEGMALQLGCLELRRFFKDMPHNALDKKSNFELLEKEVGLDLFFPKQ 217

  Fly   220 VIATSKPKNLKKLIQVGYKKVYNYNDIEYLTRFFDLLKNIYLTNFEQFSVTLSSAWNISGILHVG 284
            :....|||..:|:||..:::..:..:.|.:.:||:.|......:.|.:...|...|||:..|.:|
Mouse   218 MQENLKPKQFRKMIQQTFQQYASLREEECVMKFFNTLAGFANIDQETYRCELIQGWNITVDLVIG 282

  Fly   285 PHIGISYQTHPQASLKNVAQFKDVVSIKTCTLPKEKLSKSGENTTEPELQNFNCNCQKIKTQIKI 349
            |. ||...|........:|:||.:.||: | ||.|:        |:..||              :
Mouse   283 PK-GIRQLTSQDTKPTCLAEFKQIKSIR-C-LPLEE--------TQAVLQ--------------L 322

  Fly   350 SASNNVEDLVITCNGINTAESIADLIDGYCRLLSKDLEFTIWHRETNASNEDSAKALPNDATLGS 414
            ......:.|.|..:.:..||::||||||||||..:.....|.|.:.:....:|...:|. ..|.:
Mouse   323 GIEGAPQSLSIKTSSLAEAENMADLIDGYCRLQGEHKGSLIMHAKKDGEKRNSLPQIPT-LNLEA 386

  Fly   415 NKSTSSQGKPMLTDDYAEIGLLEGEGDYSTPTVRNYELDRALITPSAKIGVGQFGDVYVGTYTLP 479
            .:|..|:...:.:|.||||    .:.....|....|.:.|..:..:..:|.|.||:||.|.||  
Mouse   387 RRSHLSESCSIESDIYAEI----PDETLRRPGGPQYGVAREEVVLNRILGEGFFGEVYEGVYT-- 445

  Fly   480 KLGKGKNLAGNGKNSNSDQRNADSRPDVIQVAIKTCKANDDPEKTENFLAEAYIMQKFDHPHIIR 544
                                  :.:.:.|.||:||||.:...:..|.|::||.||:..|||||::
Mouse   446 ----------------------NHKGEKINVAVKTCKKDCTQDNKEKFMSEAVIMKNLDHPHIVK 488

  Fly   545 LIGICSVMPIWIVMELAKLGELRAYLKTNSERLSHGTLLKYCYQLSTALSYLESKKFVHRDIAAR 609
            ||||....|.||:|||...|||..||:.|...|...||:.|..|:..|::||||...||||||.|
Mouse   489 LIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVPTLVLYTLQICKAMAYLESINCVHRDIAVR 553

  Fly   610 NVLVSSPTCVKLADFGLSRWVSDQSYYHSTPTVALPIKWMSPESINFRRFTTASDVWMFGVCIWE 674
            |:||:||.||||.||||||::.|:.||.::.| .|||||||||||||||||||||||||.||:||
Mouse   554 NILVASPECVKLGDFGLSRYIEDEDYYKASVT-RLPIKWMSPESINFRRFTTASDVWMFAVCMWE 617

  Fly   675 ILMLGVKPFQGVKNSDVILKLENGERLPLPPNCPPRLYSLMSQCWAYEPLKRPNFKRIKETLHEI 739
            ||..|.:||..::|.|||..||.|:|||.|..|||.||:||::||.|:|..||.|..:..:|.:|
Mouse   618 ILSFGKQPFFWLENKDVIGVLEKGDRLPKPELCPPVLYTLMTRCWDYDPSDRPRFTELVCSLSDI 682

  Fly   740 --LIED-SINSSETLKREQRKVASMSWIGSDDIDIPPSKPSRVMHDPDITGLMPETTGLPQTYII 801
              :.:| :|......:....|:     :.......||.||||..:.|.           |||.::
Mouse   683 YQMEKDIAIEQERNARYRPPKI-----LEPTTFQEPPPKPSRPKYRPP-----------PQTNLL 731

  Fly   802 AQNPAVLAKLMMENQKRGINPAAYTTPASVFNTLAVGLDDSNPNVSLKTTKLPAADLLKLDPIAE 866
            |      .||..:                    :..||..|:|.                     
Mouse   732 A------PKLQFQ--------------------VPEGLCASSPT--------------------- 749

  Fly   867 SERLRSQFSANSSASQLANPLTASVNPHESLNSHQAGMFTGSLPSKSSFVVCPPQTEEHMQAENI 931
                            |.:|:                                            
Mouse   750 ----------------LTSPM-------------------------------------------- 754

  Fly   932 SNPSVSKVSGYSLYGSLERHQPPPAKAMHSKGGSLERHQSLMSAQNLVFYNTKPPPNCTNTAERS 996
                               ..|.|..::|:                       ||.:..|..:| 
Mouse   755 -------------------EYPSPVNSLHT-----------------------PPLHRHNVFKR- 776

  Fly   997 RSMERNTYFHAYRQQMKTSIECEALPEEIYDFGGIGLKTCVSARQQPKFSPMVNVRPAELGQVQN 1061
                     |:.|::               ||                      :||:.      
Mouse   777 ---------HSMREE---------------DF----------------------IRPSS------ 789

  Fly  1062 TDCMGLQQNIPMDSFGVISPHNLDESLRHQREMERQWMTSGPQSITVNPNISISEGAACLATLQA 1126
                                         :.|.::.|                          :|
Mouse   790 -----------------------------REEAQQLW--------------------------EA 799

  Fly  1127 EAMGNQGIHNVLGEKLRQQQKDSNSDSEWLIQEELLRSCSIPQGSLNDHQAQMFKLDFMSAGPSS 1191
            |.:       .:.:.|.:|||....||:||.:||   .|..|...:||                 
Mouse   800 EKI-------KMKQVLERQQKQMVEDSQWLRREE---RCLDPMVYMND----------------- 837

  Fly  1192 LPDCSNSSSRPMTPNANLSSLKSNHSSADHLSSLTSAEEQMGSNARNLGSAVPSRPP-------- 1248
                    ..|:||.      |....|...|.::::..|..|.         |.:||        
Mouse   838 --------KSPLTPE------KEAGYSECFLGTVSARAEFTGP---------PQKPPRLGAQSIQ 879

  Fly  1249 -----NRADDEVYCATTLVVKSIMALSQGVEKANTEGYLELVKNVGVKLRNLLTSVDKISIIFPA 1308
                 :|.||.||.....:|::::.|...:.:...|.|:.:|||||:.||.|:.|||.:....||
Mouse   880 PTANLDRTDDLVYHNVMTLVEAVLELKNKLGQLPPEDYVVVVKNVGLNLRKLIGSVDDLLPSLPA 944

  Fly  1309 QALKEVQMAHQVLSKDMHELVSAMRLAQQYSDTTLDCEYRKSMLSAAHVLAMDAKNLFDVVDSIR 1373
            .:..|::...::|:||:.||::.|:||||.:.|:|..:.::.||:|:|.||:|||||.|.||..:
Mouse   945 SSRTEIEGTQKLLNKDLAELINKMKLAQQNAVTSLSEDCKRQMLTASHTLAVDAKNLLDAVDQAK 1009

  Fly  1374 QRYQHLFPPS 1383
            .......||:
Mouse  1010 VVANLAHPPA 1019

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FakNP_001137718.1 B41 24..267 CDD:214604 64/241 (27%)
FERM_B-lobe 152..257 CDD:271216 32/104 (31%)
FERM_C_FAK1 263..394 CDD:270011 39/130 (30%)
PTKc_FAK 450..744 CDD:133187 143/296 (48%)
Pkinase_Tyr 462..736 CDD:285015 138/273 (51%)
Focal_AT 1249..1376 CDD:281606 49/126 (39%)
Ptk2bXP_017171415.1 FERM_N_2 39..137 CDD:407875 26/113 (23%)
B41 41..254 CDD:214604 62/230 (27%)
FERM_C_FAK1 261..368 CDD:270011 39/131 (30%)
PTKc_FAK 418..687 CDD:133187 142/293 (48%)
Focal_AT 883..1012 CDD:397606 49/128 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 116 1.000 Domainoid score I5938
eggNOG 1 0.900 - - E1_KOG4257
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 653 1.000 Inparanoid score I777
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002650
OrthoInspector 1 1.000 - - otm44146
orthoMCL 1 0.900 - - OOG6_105566
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4950
SonicParanoid 1 1.000 - - X1755
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
109.750

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