DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fak and kin-32

DIOPT Version :9

Sequence 1:	NP_001137718.1	Gene:	Fak / 37233	FlyBaseID:	FBgn0020440	Length:	1500	Species:	Drosophila melanogaster
Sequence 2:	NP_740841.1	Gene:	kin-32 / 172135	WormBaseID:	WBGene00002213	Length:	867	Species:	Caenorhabditis elegans

Alignment Length:	949	Identity:	272/949 - (28%)
Similarity:	418/949 - (44%)	Gaps:	193/949 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 EYLIHVHMPNKSFKAVRFNVKETVFHVIRRTVEDLGTDGRTPSIQRYACRMLNMITKEV------ 79
            |.|..|.:...:.||||::.:.|:..||......:|..  ..::..:|.|::...:.:.
Worm     2 EGLARVFLIGGASKAVRYDEQTTIERVIHVVARGIGIS--QVAVAHFALRLVTGPSPQTAGSGDS 64

  Fly    80 IWL---ARSTSMQKVLSHILTPGCSNVDCPNNQSELDEVLLEHGRRITDNRVWRVELRVRYVPNN 141
            :||   .|.|.:..:.:..|..|.    |       ||:              ::|:|:|::|.:
Worm    65 LWLHPMLRITQLPHIYARHLPIGV----C-------DEI--------------KLEMRMRFMPQS 104

  Fly   142 IQELFEEDKATCFYYFNQVKEDFIQANVTAIDTEVAVQLCCLGI-RHYFKNITVKAPDKKQHIDY 205
            :.||...|.:...|...||.::|..........|||:::..|.: |.:.::...|..|  .|::.
Worm   105 VYELQATDSSAFVYLHEQVVDEFFSHVAWRSSVEVALEVAALKVCRDFAEHQHNKGAD--HHLED 167

  Fly   206 IEKEIGFKSFLPQSVIATS--KPKNLKKLIQVGYKKVYNYNDIEYLTRFFDLLKNIYLTNFEQFS 268
            ::.|...:|.:| :|:...  |..:|||......||....:..|.:.|...||..:...:.|.|.
Worm   168 LDIEACIQSLIP-NVLHNPGFKHSHLKKTFTAYIKKFSATSPNESIIRSLALLLEVVKFDVELFK 231

  Fly   269 VTLSSAWNISGILHVGPHIGISYQTHPQASLKNVAQFKDVVSIKTCTLPKEKLSKSGENTTEPEL 333
            .:|.:.|.....|.||||.|:||:.:.:.....:.:.:.:..|   |:.|.      ||.:|
Worm   232 ASLGAGWTKPVELVVGPHTGLSYRLNERCDSSRLLELRTIAEI---TIRKM------ENGSE--- 284

  Fly   334 QNFNCNCQKIKTQIKISASNNVEDLVITCNGINTAESIADLIDGYCRLLS-KDLEFTIWHRETNA 397
                      ||.::::.|...:.::||.:....::|:|.|:|||..|.: :|..|.:
Worm   285 ----------KTLMQLNLSGAAKPVLITLSTEELSQSLAHLLDGYQMLYNQRDSVFKL------- 332

  Fly   398 SNEDSAKALPNDATLGSNKSTSSQGKPMLTDDYAEIGLLEGEGDYSTPTVRNYELDRALITPSAK 462
                  |.:....||..:::|.....|...|.                   |..|.|.|||....
Worm   333 ------KGIERCETLTMHEATIRPKTPNNIDS-------------------NIRLRRELITLKEL 372

  Fly   463 IGVGQFGDVYVGTYTLPKLGKGKNLAGNGKNSNSDQRNADSRPDVIQVAIKTCKANDDPEKTENF 527
            ||.||||:||...|               .:...|:|        |.||:|.||.:.:|..|:..
Worm   373 IGGGQFGNVYKAVY---------------HDLEKDER--------IAVAVKVCKTDAEPADTQLI 414

  Fly   528 LAEAYIMQKFDHPHIIRLIGICSVMPIWIVMELAKLGELRAYLKTNSERLSHGTLLKYCYQLSTA 592
            |.|:.:|:.|.|.:||:|||:|...|:|:|:|||..||||.||:...:.|....|..:|.|:..:
Worm   415 LQESSLMRNFRHSNIIQLIGVCVDQPMWLVLELAPKGELREYLQQEKDWLPLRILTLFCSQICDS 479

  Fly   593 LSYLESKKFVHRDIAARNVLVSSPTCVKLADFGLSRWVSDQSYYHSTPTVALPIKWMSPESINFR 657
            |.||.|.:||||||||||:||.||.||||||||||| ..|....::.....|||||::|||:|:|
Worm   480 LVYLHSTRFVHRDIAARNILVCSPQCVKLADFGLSR-ALDYDAVYTASRGKLPIKWLAPESVNYR 543

  Fly   658 RFTTASDVWMFGVCIWEILMLGVKPFQGVKNSDVILKLENGERLPLPPNCPPRLYS-LMSQCWAY 721
            :|:.||||||||||:|||..|||||:.||.|||||:.:|.|.|.|.|..||..||: :.|:.||.
Worm   544 QFSMASDVWMFGVCMWEIFSLGVKPWAGVTNSDVIMHIEQGSRPPCPEKCPTALYNFIRSKMWAI 608

  Fly   722 EPLKRPNFKRIKETLHE-------------------------ILIEDSINSSETLKR---EQRKV 758
            ||.|||...:|...:.:                         |:.|.|.....||.|   :|::.
Worm   609 EPHKRPTVDQIYAIIEDVRQQIIQNIPPEQIIVGKPMTAAGVIVAEMSSLPGLTLYRTMEDQKRQ 673

  Fly   759 A--SMSWIGSD--------DID-IPPSKPSRVMHDPDITGLMPETTGLPQTYIIAQNPAVLAKLM 812
            |  ...|:..:        ||| ||.:..|.|.:.....|.:..|            |.....|.
Worm   674 AEEDAKWLEQEDDEDEDDQDIDQIPSTSHSSVENIRTSNGYLHHT------------PTSTRSLR 726

  Fly   813 MENQ-KRGINPA------AYTTPASVFNTLAVGLDDSNPNVSLKTTKLPAADLLKLDPIAESERL 870
            .|:: .||:..:      |.|...:.||.|... ||     .|.:.|...:.|.::..:|...|.
Worm   727 FEDKTSRGLRRSVDGVCDAVTKLQNSFNNLTHN-DD-----FLHSVKEVTSQLREMLIVASGMRD 785

  Fly   871 RSQFSANSSASQLANPLTAS-------VNPHESLNSHQA 902
            |...:...:...:...|.|:       |.....:|.|||
Worm   786 RVTTTTQRTDVDMTKTLIANDMKQMSRVMGKLQVNGHQA 824

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fak	NP_001137718.1	B41	24..267	CDD:214604	54/254 (21%)
		FERM_B-lobe	152..257	CDD:271216	25/107 (23%)
		FERM_C_FAK1	263..394	CDD:270011	32/131 (24%)
		PTKc_FAK	450..744	CDD:133187	137/319 (43%)
		Pkinase_Tyr	462..736	CDD:285015	130/274 (47%)
		Focal_AT	1249..1376	CDD:281606
kin-32	NP_740841.1	B41	5..230	CDD:214604	54/254 (21%)
		FERM_C_FAK1	226..336	CDD:270011	33/144 (23%)
		PKc_like	360..631	CDD:304357	135/294 (46%)
		STYKc	367..623	CDD:214568	132/279 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167286
Domainoid	1	1.000	246	1.000	Domainoid score	I1200
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7314
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D29350at33208
OrthoFinder	1	1.000	-	-		FOG0002650
OrthoInspector	1	1.000	-	-		oto17926
orthoMCL	1	0.900	-	-		OOG6_105566
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4950
SonicParanoid	1	1.000	-	-		X1755
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.780