Protein Alignment Fak and Hck

DIOPT Version :10

• Sequence 1: NP_001137718.1
• Gene: Fak / 37233
• FlyBaseID: FBgn0020440
• Length: 1500
• Species: Drosophila melanogaster
• Sequence 2: NP_034537.2
• Gene: Hck / 15162
• MGIID: 96052
• Length: 524
• Species: Mus musculus
• Alignment Length: 309
• Identity: 109/309 - (35%)
• Similarity: 166/309 - (53%)
• Gaps: 41/309 - (13%)

  Fly   450 YELDRALITPSAKIGVGQFGDVYVGTYTLPKLGKGKNLAGNGKNSNSDQRNADSRPDVIQVAIKT 514
            :|:.|..:....|:|.||||:|::.||                |.::            :||:||
Mouse   253 WEIPRESLQMEKKLGAGQFGEVWMATY----------------NKHT------------KVAVKT 289

  Fly   515 CKANDDPEKTENFLAEAYIMQKFDHPHIIRLIGICSVMPIWIVMELAKLGELRAYLKTNSERLSH 579
            .|...  ...|.|||||.:|:...|..:::|..:.|..||:||.|....|.|..:||  ||..|.
Mouse   290 MKPGS--MSVEAFLAEANLMKSLQHDKLVKLHAVVSQEPIFIVTEFMAKGSLLDFLK--SEEGSK 350

  Fly   580 GTLLK---YCYQLSTALSYLESKKFVHRDIAARNVLVSSPTCVKLADFGLSRWVSDQSYYHSTPT 641
            ..|.|   :..|:|..::::|.:.::|||:.|.|:|||:....|:|||||:|.:.|.. |.:...
Mouse   351 QPLPKLIDFSAQISEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARIIEDNE-YTAREG 414

  Fly   642 VALPIKWMSPESINFRRFTTASDVWMFGVCIWEILMLGVKPFQGVKNSDVILKLENGERLPLPPN 706
            ...||||.:||:|||..||..||||.||:.:.||:..|..|:.|:.|.:||..||:|.|:|.|.|
Mouse   415 AKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALEHGYRMPRPDN 479

  Fly   707 CPPRLYSLMSQCWAYEPLKRPNFKRIKETLHEILIEDSINSSETLKREQ 755
            ||..||::|.:||...|.:||.|:.|:..|     :|...::|:..::|
Mouse   480 CPEELYNIMIRCWKNRPEERPTFEYIQSVL-----DDFYTATESQYQQQ 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fak	NP_001137718.1	B41	24..267	CDD:214604
		FERM_B-lobe	152..257	CDD:271216
		FERM_C_FAK1	263..394	CDD:270011
		PTKc_FAK	450..744	CDD:133187	106/296 (36%)
		Focal_AT	1250..1376	CDD:460992
Hck	NP_034537.2	SH3	80..135	CDD:473055
		SH2_Src_HCK	138..241	CDD:198226
		Protein Kinases, catalytic domain	252..522	CDD:473864	108/306 (35%)