Protein Alignment Fak and ptk2ab

DIOPT Version :10

• Sequence 1: NP_001137718.1
• Gene: Fak / 37233
• FlyBaseID: FBgn0020440
• Length: 1500
• Species: Drosophila melanogaster
• Sequence 2: XP_073780623.1
• Gene: ptk2ab / 142986
• ZFINID: ZDB-GENE-020114-1
• Length: 1231
• Species: Danio rerio
• Alignment Length: 1476
• Identity: 471/1476 - (31%)
• Similarity: 665/1476 - (45%)
• Gaps: 400/1476 - (27%)

  Fly     4 AGATSQPPPTKNEINSEEYLIHVHMPNKSFKAVRFN--VKET---------VFHVIRRTVEDL-- 55
            |.|...|.||             |..|:..|. ||:  ::.|         :||....:.|..
Zfish    40 AAAYLDPNPT-------------HALNQGVKP-RFSSGMERTAAALERVLKIFHYFESSSEPCSW 90

  Fly    56 --------GTDGR-----TPSIQRYAC------RMLNMITKEVIWLARSTSMQKVLSHILTPGCS 101
                    .||.|     ...|.:..|      |:.::.|.|:.||.....    :||:
Zfish    91 ASNIRHGDSTDVRGIIQKILDIHKVRCVSCFGLRLSHLRTGEIHWLHPDMG----VSHV------ 145

  Fly   102 NVDCPNNQSELDEVLLEHGRRITDNRVWRVELRVRYVPNNIQELFEEDKATCFYYFNQVKEDFIQ 166
                        ....||.....|   ||.|||:||:|......|.||:.|..|:::|||.|::.
Zfish   146 ------------RERYEHSHPQDD---WRYELRIRYLPKGFLNQFTEDQPTLNYFYHQVKSDYMM 195

  Fly   167 ANVTAIDTEVAVQLCCLGIRHYFKNITVKAPDKKQHIDYIEKEIGFKSFLPQSVIATSKPKNLKK 231
            .....:|.::|::|.||.||.:|:::...|.|||.:.:.:||::|.:.|.|:|::.:.|.|:|:|
Zfish   196 EIADQVDQDIALKLGCLEIRRFFRDMPGNALDKKSNYELLEKDVGLRRFFPKSLLDSVKAKSLRK 260

  Fly   232 LIQVGYKKVYNYNDIEYLTRFFDLLKNIYLTNFEQFSVTLSSAWNISGILHVGPHIGISYQTHPQ 296
            |||..:|:..|.|:.:.:.:||::|..||..:.|.|...|.|:|.||..|.:||..||||.|...
Zfish   261 LIQQTFKQFANLNNEQCMLKFFEILSPIYRFDKECFKCALGSSWVISVELAIGPEEGISYLTDKG 325

  Fly   297 ASLKNVAQFKDVVSIKTCTLPKEKLSKSGENTTEPELQNFNCNCQKIKTQIKISASNNVEDLVIT 361
            ::..::|.|..|.:|:.     |:..:.|                    .:.:..:...|.|.:|
Zfish   326 SNPTHLANFTQVQTIQF-----EERERKG--------------------MLLLDVAGAPEPLTVT 365

  Fly   362 CNGINTAESIADLIDGYCRLLSKDLEFTIWHRETNAS-----NEDSAKALPN--DATLGSNKSTS 419
            ...:||||::||||||||||:|          .|::|     .::..:|||:  .|...:|....
Zfish   366 TTTLNTAENMADLIDGYCRLVS----------GTSSSFIVRVQKEGERALPSIPKAPKSANHEKR 420

  Fly   420 SQG---KPML---------TDDYAEIGLLEGEGDYSTPT-------VRNYELDRALITPSAKIGV 465
            .||   |.:.         |||||||  ::.|..|:.|:       .|:||:.|..|.....||.
Zfish   421 LQGVRAKAISISDDIGGDETDDYAEI--IDEEDTYTMPSKYYGLDEARDYEIQRDRIELGRCIGE 483

  Fly   466 GQFGDVYVGTYTLPKLGKGKNLAGNGKNSNSDQRNADSRPDVIQVAIKTCKANDDPEKTENFLAE 530
            ||||||:.|.|..|.                        ...:.|||||||........|.||.|
Zfish   484 GQFGDVHQGIYICPD------------------------TPALSVAIKTCKNCTSDSVREKFLQE 524

  Fly   531 AYIMQKFDHPHIIRLIGICSVMPIWIVMELAKLGELRAYLKTNSERLSHGTLLKYCYQLSTALSY 595
            |..|::||||||::|||:.:..|:||:|||..|||||::|:.....|...:|:.:.|||||||:|
Zfish   525 ALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQIRKYNLDLASLILFSYQLSTALAY 589

  Fly   596 LESKKFVHRDIAARNVLVSSPTCVKLADFGLSRWVSDQSYYHSTPTVALPIKWMSPESINFRRFT 660
            ||||:|||||||||||||||..||||.||||||::.|.|||.::.. .||||||:||||||||||
Zfish   590 LESKRFVHRDIAARNVLVSSVDCVKLGDFGLSRYMEDSSYYKASKG-KLPIKWMAPESINFRRFT 653

  Fly   661 TASDVWMFGVCIWEILMLGVKPFQGVKNSDVILKLENGERLPLPPNCPPRLYSLMSQCWAYEPLK 725
            :||||||||||:|||||.||||||||||:|||.::||||||.:||||||.|||||::||||:|.|
Zfish   654 SASDVWMFGVCMWEILMYGVKPFQGVKNNDVIGRIENGERLAMPPNCPPTLYSLMTKCWAYDPSK 718

  Fly   726 RPNFKRIKETLHEILIEDSINSSETLKREQRKVASMSWI--GSDDIDIPPSKPSR---VMHDPDI 785
            ||.|..:|..|..||.|:.....|..:.|.|:...:||.  |||:   .|.||||   :.|...:
Zfish   719 RPRFTELKGQLSTILAEEKAQQEERSRMEMRRQVPVSWDSGGSDE---APPKPSRRRPLQHSFSM 780

  Fly   786 TGLMPETTGLPQTYIIAQNPAVLAKLMMENQKRGINPAAYTTPASVFNTLAVGLDDSNPNVSLKT 850
            ..|.|..:                           ..||...|...|.        |..::..:.
Zfish   781 DCLSPSVS---------------------------TSAASRPPQQPFG--------SQISLCFRQ 810

  Fly   851 TKLPAADLLK------LDPIAESERLRSQFSANSSASQLANPLTASVNPHESLNSHQAGMFTGSL 909
            |: |:|..||      ::|.|..::...|.|..:....|..||..    |.||...|.
Zfish   811 TE-PSASPLKPCVKSIINPSAHMQQNTPQLSIQTQRPLLLEPLPL----HCSLLFPQG------- 863

  Fly   910 PSKSSFVVCPPQTEEHMQAENISNPSVSKVSGYSLYGSLERHQPPPAKAMHSKGGSLERHQSLMS 974
                      |:|          .|||                 ||.
Zfish   864 ----------PRT----------RPSV-----------------PPG------------------ 873

  Fly   975 AQNLVFYNTKPPPNCTNTAERSRSMERNTYFHA-YRQQMKTSIECEALPEEIYDFGGIGLKTCVS 1038
                :|::...|           ||::.:..|| ||   .|.......|               |
Zfish   874 ----IFFDPYYP-----------SMQQLSLSHAPYR---FTQPSRPGYP---------------S 905

  Fly  1039 ARQQPKFSPMVNVRPAELGQVQNTDCMGLQQNIPMDSFGV-------------ISPHNLDESLRH 1090
            .|....|.|    .|..:||..:....|  .:.|.....|             :.||   :|..|
Zfish   906 PRSSEGFYP----SPQHMGQHNHYQMAG--HSGPHGLLSVPGGLYPPQATVTGLDPH---DSWNH 961

  Fly  1091 QR-EMERQWMTSGPQSITVNPNISISEGAACLATLQAEAMGNQGIHNVLGEKLRQQQKDSNSDSE 1154
            :| ..:..|          ||  |:.:|.|.          ..|:..::.|:|..||:....|..
Zfish   962 RRVAQDHMW----------NP--SMEDGVAL----------RGGLSQLMEEQLILQQQQMEDDQR 1004

  Fly  1155 WLIQEE-LLR--------SCSIPQGSL-----NDHQAQMFKLDFMSAGPSSLPDCSNSSSRPMTP 1205
            ||..|| ||:        |.....|||     |.|..|.......:|.|...|       ||..|
Zfish  1005 WLEHEERLLKPDGRSSRGSTERDDGSLQGPTGNQHIYQPIGKAEHAAPPKKPP-------RPGAP 1062

  Fly  1206 NANLSSLKSNHSSADHLSSLTSAEEQMGSNARNLGSAVPSR----PP----NRADDEVYCATTLV 1262
                       |.|..:|.|...|      :.|.|..:..:    ||    :|::|:||...|.:
Zfish  1063 -----------SHAAGVSGLNPTE------SYNEGVKIQPQEINPPPTANLDRSNDKVYENVTGL 1110

  Fly  1263 VKSIMALSQGVEKANTEGYLELVKNVGVKLRNLLTSVDKISIIFPAQALKEVQMAHQVLSKDMHE 1327
            ||:::.:|..::.|..|.|:.:||.||:.||.||.:||:...:.||...:|::||.::|:.|:.|
Zfish  1111 VKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVDETIPLLPAHTHREIEMAQKLLNSDLAE 1175

  Fly  1328 LVSAMRLAQQYSDTTLDCEYRKSMLSAAHVLAMDAKNLFDVVDSIR 1373
            |::.|:|||||..|:|..:|:|.||:|||.||:|||||.||:|..|
Zfish  1176 LINKMKLAQQYVMTSLQQDYKKQMLTAAHALAVDAKNLLDVIDQAR 1221

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fak	NP_001137718.1	B41	24..267	CDD:214604	75/274 (27%)
		FERM_B-lobe	152..257	CDD:271216	36/104 (35%)
		FERM_C_FAK1	263..394	CDD:270011	39/130 (30%)
		PTKc_FAK	450..744	CDD:133187	167/293 (57%)
		Focal_AT	1250..1376	CDD:460992	56/124 (45%)
ptk2ab	XP_073780623.1	None