Protein Alignment Fak and Ptk2

DIOPT Version :10

• Sequence 1: NP_001137718.1
• Gene: Fak / 37233
• FlyBaseID: FBgn0020440
• Length: 1500
• Species: Drosophila melanogaster
• Sequence 2: XP_006520478.1
• Gene: Ptk2 / 14083
• MGIID: 95481
• Length: 1140
• Species: Mus musculus
• Alignment Length: 1382
• Identity: 432/1382 - (31%)
• Similarity: 622/1382 - (45%)
• Gaps: 415/1382 - (30%)

  Fly    48 IRRTVEDLGTDGRTPSIQRYACRMLNMITKEVIWLARSTSMQKVLSHILTPGCSNVDCPNNQSEL 112
            :|..::.:....:...:..|..|:.::.::||.||           |: ..|.|:|        .
Mouse   108 VRGIIQKIVDSHKVKHVACYGFRLSHLRSEEVHWL-----------HV-DMGVSSV--------R 152

  Fly   113 DEVLLEHGRRITDNRVWRVELRVRYVPNNIQELFEEDKATCFYYFNQVKEDFIQANVTAIDTEVA 177
            ::..|.|     ....|:.|||:||:|......|.|||.|..:::.|||.|::|.....:|.|:|
Mouse   153 EKYELAH-----PPEEWKYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKSDYMQEIADQVDQEIA 212

  Fly   178 VQLCCLGIRHYFKNITVKAPDKKQHIDYIEKEIGFKSFLPQSVIATSKPKNLKKLIQVGYKKVYN 242
            ::|.||.||..:..:...|.:||.:.:.:||::|.|.|.|:|::.:.|.|.|:||||..:::..|
Mouse   213 LKLGCLEIRRSYWEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKAKTLRKLIQQTFRQFAN 277

  Fly   243 YNDIEYLTRFFDLLKNIYLTNFEQFSVTLSSAWNISGILHVGPHIGISYQTHPQASLKNVAQFKD 307
            .|..|.:.:||::|..:|..:.|.|...|.|:|.||..|.:||..||||.|....:..::|.|..
Mouse   278 LNREESILKFFEILSPVYRFDKECFKCALGSSWIISVELAIGPEEGISYLTDKGCNPTHLADFNQ 342

  Fly   308 VVSIKTCTLPKEKLSKSGENTTEPELQNFNCNCQKIKTQIKISASNNVEDLVITCNGINTAESIA 372
            |.:|                    :..|.....:|...|:||:.:  .|.|.:|...:..||::|
Mouse   343 VQTI--------------------QYSNSEDKDRKGMLQLKIAGA--PEPLTVTAPSLTIAENMA 385

  Fly   373 DLIDGYCRLLSKDLEFTIWHRETNASNEDSAKALPNDATLGSNK-------STSSQG-------- 422
            |||||||||::...:..|...:     ::..:|||:...|.:::       :.|..|
Mouse   386 DLIDGYCRLVNGATQSFIIRPQ-----KEGERALPSIPKLANSEKQGMRTHAVSVSGVSHCQHKV 445

  Fly   423 ------KPML----------------TDDYAEIGLLEGEGDYSTPT-------VRNYELDRALIT 458
                  .|::                |||||||  ::.|..|:.|:       .|:||:.|..|.
Mouse   446 KKARRFLPLVFCSLEPPPTDEISGDETDDYAEI--IDEEDTYTMPSKSYGIDEARDYEIQRERIE 508

  Fly   459 PSAKIGVGQFGDVYVGTYTLPKLGKGKNLAGNGKNSNSDQRNADSRPDVIQVAIKTCKANDDPEK 523
            ....||.||||||:.|.|..|:                       .| .:.|||||||.......
Mouse   509 LGRCIGEGQFGDVHQGVYLSPE-----------------------NP-ALAVAIKTCKNCTSDSV 549

  Fly   524 TENFLAEAYIMQKFDHPHIIRLIGICSVMPIWIVMELAKLGELRAYLKTNSERLSHGTLLKYCYQ 588
            .|.||.||..|::||||||::|||:.:..|:||:|||..|||||::|:.....|...:|:.|.||
Mouse   550 REKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQ 614

  Fly   589 LSTALSYLESKKFVHRDIAARNVLVSSPTCVKLADFGLSRWVSDQSYYHSTPTVALPIKWMSPES 653
            |||||:|||||:|||||||||||||||..||||.||||||::.|.:||.::.. .||||||:|||
Mouse   615 LSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKG-KLPIKWMAPES 678

  Fly   654 INFRRFTTASDVWMFGVCIWEILMLGVKPFQGVKNSDVILKLENGERLPLPPNCPPRLYSLMSQC 718
            |||||||:||||||||||:|||||.||||||||||:|||.::|||||||:||||||.|||||::|
Mouse   679 INFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKC 743

  Fly   719 WAYEPLKRPNFKRIKETLHEILIEDSINSSETLKREQRKVASMSWI--GSDDIDIPPSKPSRVMH 781
            |||:|.:||.|..:|..|..||.|:.:...|.::.|.|:.|::||.  |||:   .|.||||
Mouse   744 WAYDPSRRPRFTELKAQLSTILEEEKVQQEERMRMESRRQATVSWDSGGSDE---APPKPSR--- 802

  Fly   782 DPDITGLMPETTGLPQTYIIAQNPAVLAKLMMENQKRGINPAAYTTPASVFNTLAVGLDDSNPNV 846
                                                     ..|.:|.|
Mouse   803 -----------------------------------------PGYPSPRS---------------- 810

  Fly   847 SLKTTKLPAADLLKLDPIAESERLRSQFSANSSASQLANPLTASVNPHESLNSHQAGMFTGSLPS 911
                                ||                                      |..||
Mouse   811 --------------------SE--------------------------------------GFYPS 817

  Fly   912 KSSFVVCPPQTEEHMQAENISNPSVSKVSGYSLYGSLERHQPPPAKAMHSKGGSLERHQ-SLMSA 975
            ....|    ||..:            :||||           |.:..:.:..||:.:.| ||:..
Mouse   818 PQHMV----QTNHY------------QVSGY-----------PGSHGIPAMAGSIYQGQASLLDQ 855

  Fly   976 QNLVFYNTKPPPNCTNTAERSRSMERNTYFHAYRQQMKTSIECEALPEEIYDFGGIGLKTCVSAR 1040
            ..|  :|.:|                        |:|.
Mouse   856 TEL--WNHRP------------------------QEMS--------------------------- 867

  Fly  1041 QQPKFSPMVNVRPAELGQVQNTDCMGLQQNIPMDSFGVISPHNLDESL-RHQREME--RQWMTSG 1102
               .:.|.|....|       .|..|:.|.:|        ||.::|.| |.|:|||  ::|:..
Mouse   868 ---MWQPSVEDSAA-------LDLRGMGQVLP--------PHLMEERLIRQQQEMEEDQRWLEK- 913

  Fly  1103 PQSITVNPNISISEGAACLATLQAEAMGNQGIHNVLGEKLRQQQKDSNSDSEWLIQEELLRSCSI 1167
             :...:.|::.:|.|     ::..|....||
Mouse   914 -EERFLKPDVRLSRG-----SIDREDGSFQG---------------------------------- 938

  Fly  1168 PQGSLNDHQAQMFKLDFMSAGPSSLPDCSNSSSRPMTPNA--NLSSLKSNHSSADHLSSLTSAEE 1230
            |.|  |.|..|          |...||.:....:|..|.|  :||:|.|..|.||..:.
Mouse   939 PTG--NQHIYQ----------PVGKPDPAAPPKKPPRPGAPGHLSNLSSISSPADSYNE------ 985

  Fly  1231 QMGSNARNLGSAVPSRPP----NRADDEVYCATTLVVKSIMALSQGVEKANTEGYLELVKNVGVK 1291
              |.....|.....|.||    :|::|:||...|.:||:::.:|..::.|..|.|:.:||.||:.
Mouse   986 --GVKPWRLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLA 1048

  Fly  1292 LRNLLTSVDKISIIFPAQALKEVQMAHQVLSKDMHELVSAMRLAQQYSDTTLDCEYRKSMLSAAH 1356
            ||.||.:||:.....||...:|::||.::|:.|:.||:|.|:|||||..|:|..||:|.||:|||
Mouse  1049 LRTLLATVDETIPALPASTHREIEMAQKLLNSDLGELISKMKLAQQYVMTSLQQEYKKQMLTAAH 1113

  Fly  1357 VLAMDAKNLFDVVDSIR 1373
            .||:|||||.||:|..|
Mouse  1114 ALAVDAKNLLDVIDQAR 1130

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fak	NP_001137718.1	B41	24..267	CDD:214604	63/218 (29%)
		FERM_B-lobe	152..257	CDD:271216	36/104 (35%)
		FERM_C_FAK1	263..394	CDD:270011	40/130 (31%)
		PTKc_FAK	450..744	CDD:133187	168/293 (57%)
		Focal_AT	1250..1376	CDD:460992	58/124 (47%)
Ptk2	XP_006520478.1	FERM_N_2	79..174	CDD:436229	19/90 (21%)
		B41	80..302	CDD:214604	63/218 (29%)
		FERM_C_FAK1	298..408	CDD:270011	40/136 (29%)
		PTKc_FAK	500..769	CDD:133187	168/293 (57%)
		Focal_AT	1004..1133	CDD:460992	58/127 (46%)