Protein Alignment Fak and Fak

DIOPT Version :10

• Sequence 1: NP_001137718.1
• Gene: Fak / 37233
• FlyBaseID: FBgn0020440
• Length: 1500
• Species: Drosophila melanogaster
• Sequence 2: XP_061513649.1
• Gene: Fak / 1270807
• VectorBaseID: AGAMI1_004652
• Length: 2698
• Species: Anopheles gambiae
• Alignment Length: 1798
• Identity: 727/1798 - (40%)
• Similarity: 949/1798 - (52%)
• Gaps: 388/1798 - (21%)

  Fly    11 PPTKNEINSEEYLIHVHMPNKSFKAVRFNVKETVFHVIRRTVEDLGTDGRTPSIQRYACRMLNMI 75
            |..:.....:...:||::||..|:.:||:....|..:|...|..: :.|:.|:.|.||.|:.:|:
Mosquito   844 PSRQTTQTGDTQTLHVYLPNHGFRMIRFDEASDVRQIINLIVGWM-SPGQKPNPQSYALRLRHML 907

  Fly    76 TKEVIWLARSTSMQKVLSHILTPGCSNVDCPN-NQSELDEVL-------LEHGRRITDNRVWRVE 132
            ||||:|:...|||.:|::||..|.|||.|||| ::|.:.:.:       :.|.     |.||:.|
Mosquito   908 TKEVLWMPPDTSMSQVMAHIYNPSCSNADCPNVDKSTIAKRMQQKTSGAIGHA-----NSVWKAE 967

  Fly   133 LRVRYVPNNIQELFEEDKATCFYYFNQVKEDFIQANVTAIDTEVAVQLCCLGIRHYFKNITVKAP 197
            |||||:|.|::||:|.|:.||.:||:|||:|:||:||..||.|:||||||||||||:|:....:.
Mosquito   968 LRVRYIPKNLKELYERDRTTCHFYFDQVKQDYIQSNVPHIDPEIAVQLCCLGIRHYYKDTNHTSN 1032

  Fly   198 DKKQHIDYIEKEIGFKSFLPQSVIATSKPKNLKKLIQVGYKKVYNYNDIEYLTRFFDLLKNIYLT 262
            |:|||:||||||:||.:|:|:|||.|.|.|||||.||.||||||:|:::||:.:|||||:..|..
Mosquito  1033 DRKQHLDYIEKEMGFGNFIPKSVIDTIKQKNLKKQIQAGYKKVYSYSEMEYMLKFFDLLRTQYTF 1097

  Fly   263 NFEQFSVTLSSAWNISGILHVGPHIGISYQTHPQASLKNVAQFKDVVSIKTCTLPK--------- 318
            :.|||:|.|||:|||...|.:|||:|:||..:|||....|..|:.:..|.|..||.
Mosquito  1098 DQEQFNVQLSSSWNIRVDLIIGPHVGLSYSVNPQAPPTKVTDFESIERITTSILPTSLTKSDHQG 1162

  Fly   319 ---------------------------EKLSKSGENTTEPELQNFNCNCQKIKTQIKISASNNVE 356
                                       :|..|.|:...........|.|.:||||::|..|.|.|
Mosquito  1163 GRGAKGKDQPDLTSSCGSNASAGDGAGDKGKKDGKKGASAGATGSQCACGEIKTQLRIRVSGNSE 1227

  Fly   357 DLVITCNGINTAESIADLIDGYCRLLSKDLEFTIWHRETNASNEDSAKALP---NDATLGSNKS- 417
            ||.|||:||.|:||||||:||||||.:|: :.::|.|........:|.|.|   |.||....||
Mosquito  1228 DLAITCDGIKTSESIADLVDGYCRLFNKN-DNSLWDRTVIPKGGGAAAATPPAGNSATNSLEKSQ 1291

  Fly   418 -----TSSQ----------------------------GKPMLTDDYAEIGLLEGEGDYSTPTVRN 449
                 |.||                            .||.|.:||||:|:.:.|||||||..|:
Mosquito  1292 LKKSLTESQTSSTDRHGSRSSSADRLNGGSGGELAEPPKPTLNEDYAELGMCDEEGDYSTPAARD 1356

  Fly   450 YELDRALITPSAKIGVGQFGDVYVGTYTLP-------KLGKGKNLAGN-GKNSNSDQRNADS-RP 505
            |||||:.||.:..|||||||||::|:..||       ||  .::|... .:.|..|..|||: :.
Mosquito  1357 YELDRSQITLNEIIGVGQFGDVHIGSCRLPNKSTLVSKL--NQSLTSEFDEYSQMDNGNADAQKT 1419

  Fly   506 DVIQVAIKTCKANDDPEKTENFLAEAYIMQKFDHPHIIRLIGICSVMPIWIVMELAKLGELRAYL 570
            .:||||:||||.:.|...:|.||.|||||:||:|||||:||||.|..|||||||||:.|||||||
Mosquito  1420 GIIQVAVKTCKPDADTTTSEKFLQEAYIMKKFEHPHIIKLIGISSGPPIWIVMELARHGELRAYL 1484

  Fly   571 KTNSERLSHGTLLKYCYQLSTALSYLESKKFVHRDIAARNVLVSSPTCVKLADFGLSRWVSDQSY 635
            |.|..:|..||||.|.||||||||||||||||||||||||||||||||:|||||||||||.||||
Mosquito  1485 KKNGPKLKLGTLLLYSYQLSTALSYLESKKFVHRDIAARNVLVSSPTCIKLADFGLSRWVEDQSY 1549

  Fly   636 YHSTPTVALPIKWMSPESINFRRFTTASDVWMFGVCIWEILMLGVKPFQGVKNSDVILKLENGER 700
            |.||..: ||||||:|||||||||||||||||||||.|||||||:||||||||.|||.|||||||
Mosquito  1550 YTSTKGM-LPIKWMAPESINFRRFTTASDVWMFGVCTWEILMLGIKPFQGVKNCDVIGKLENGER 1613

  Fly   701 LPLPPNCPPRLYSLMSQCWAYEPLKRPNFKRIKETLHEILIEDSINSSETLKREQRKVASMSWIG 765
            |||||||||||||||||||:.|||||||||.:||||:|||:|:..:..||::||.|:||:||| |
Mosquito  1614 LPLPPNCPPRLYSLMSQCWSLEPLKRPNFKSVKETLYEILMEERHSDCETMRRENRRVAAMSW-G 1677

  Fly   766 SDDIDIPPSKPSRVMHDPDITGLMPETTGLPQTYIIAQNPAVLAKLMMENQKRGINPAAYTTPAS 830
            :.| |:.|.||:|   .|.:.|..|...|.|||||:|::|.|||.||.||::|||||::||||||
Mosquito  1678 AGD-DMAPPKPAR---GPTMGGDGPLVPGAPQTYIVARDPTVLAALMRENEQRGINPSSYTTPAS 1738

  Fly   831 V-------------FNTLA------------------------------------VGLDDSNPN- 845
            .             .|::.                                    ||     ||
Mosquito  1739 AQQQHQTQQPYYPQGNSIVTYQQYHAQHQQALAAEYYQHQQQQQQYVMQQAQPQQVG-----PNY 1798

  Fly   846 -----VSLKTTK-------LPAADLLKLDPIAESE----RLRSQFSANSSASQLANPLTASVNPH 894
                 ..::|.:       .|||..:| .|..|.:    :.|| ...|::...:.:...|.:|..
Mosquito  1799 MPYGAAPVQTVQPAAGAQYQPAAAYVK-SPQQEDQPGGTKTRS-LERNAAGQNIVSAYAARINSL 1861

  Fly   895 E-------------------SLNSHQAGMFTGSLPSKSSFVVCPPQTEEHMQAENISNPSVSKVS 940
            |                   ||....:|.....|.......|.....|...|..:......:..:
Mosquito  1862 ERTRQMSMEYGNSVKAMRSNSLTRQYSGGNQSDLYPGVGHGVRSASLERGAQMASAGTVGGNNGA 1926

  Fly   941 GY-SLYGSLERHQPPPAKAM---HSKGGSLERHQSLMSAQNLVFYNTKPPPN-----------CT 990
            || |..|||||:|...::::   ..|||||||:||.....:::  |:|....           .|
Mosquito  1927 GYMSRMGSLERNQQTASQSIFLNSMKGGSLERNQSAAIVNDMM--NSKIAYKGGSLERNQHILLT 1989

  Fly   991 NTAERSRSMERNTYFHAYRQQMKTS-IECEALPEEIYDFGGIGLKTCVSARQQ------------ 1042
            .:.....|:|||..|..||..:..: .|.|...||||||||:.:|:|.|...:
Mosquito  1990 RSGSAVGSLERNMPFQNYRSPVAAAPKEQEPFQEEIYDFGGVNVKSCASIALKKSVEKGMLPPSS 2054

  Fly  1043 -------PKFSPMVNVR---PAELGQVQNTDCMGLQQNIPMDS-FGVISPHNLDESLRHQREMER 1096
                   |..|...|..   |......|.......||..|..: :|..:..|:  .:..|..|::
Mosquito  2055 LAVSPGLPPSSGGANFALPPPYSSASKQQQAAASQQQGTPQRAMWGGTAGGNI--GMHQQMYMQQ 2117

  Fly  1097 QWMTSGP-------------QSITVNPNISISEGAAC--------LATLQAEAMGN--------- 1131
            |....||             |.:.:...||.|:....        |||..|:.:.:
Mosquito  2118 QQQQQGPVQPAGPIIGIASSQQVQIPMKISHSQPVQAHPVQPVQQLATSVAQPVQHIQQQQQQQQ 2182

  Fly  1132 ---------------QGIHNVLGEKLRQQQKDSNSDSEWLIQEE--------LL----RSCSIPQ 1169
                           |.....|.||||:||::|..||:||.|||        |:    .|.|:.|
Mosquito  2183 QQMVDQQQQQQPAQLQETQQQLEEKLRKQQQESEIDSKWLQQEENNLKKRLSLITANAASMSLDQ 2247

  Fly  1170 -----------------------GSLNDHQAQMFKLDFMSAGPSSLPD-----CSNSSSRPMTPN 1206
                                   ||.:..|:..|......:||.||.|     .:.|.|||.||.
Mosquito  2248 PLGGGAPMEGSTPPVNGGGSSLSGSYHSQQSPHFSPQNTMSGPQSLGDHYPTTPNTSDSRPHTPG 2312

  Fly  1207 ANLSS-----LKSNHSSADHLSSLTSAEEQMGSNARNLGSAVPSR--PPNRADDEVYCATTLVVK 1264
            :....     :||..||.:..::..|.:|:..     :....|::  |.:|.:|.||.|||.|||
Mosquito  2313 SGGGGGGGGMIKSKSSSMERCTTPQSGDEKFA-----VKKVEPTKTMPLDRTNDMVYNATTSVVK 2372

  Fly  1265 SIMALSQGVEKANTEGYLELVKNVGVKLRNLLTSVDKISIIFPAQALKEVQMAHQVLSKDMHELV 1329
            |||||||||::|....||.||:|||.:||.||.:||::|..||.|..|||:|||:||||||:|||
Mosquito  2373 SIMALSQGVDRAQAAEYLNLVRNVGFELRALLGAVDQLSANFPPQRYKEVEMAHKVLSKDMYELV 2437

  Fly  1330 SAMRLAQQYSDTTLDCEYRKSMLSAAHVLAMDAKNLFDVVDSIRQRYQHLFP-------PSATKE 1387
            :|||||||||:||||.||||||||||||||||||||.|||||||.||.:|||       |||...
Mosquito  2438 TAMRLAQQYSETTLDAEYRKSMLSAAHVLAMDAKNLLDVVDSIRVRYPNLFPQQQQPQQPSAPSS 2502

  Fly  1388 TSCSSSFESTSGSIVAEPVNDLGGYIKTSTS-----------GDLLQN----------------- 1424
            .:......:||.:....|.|....:.:....           ||..||
Mosquito  2503 PTQRQHGAATSVTSAVHPSNTPQMFAQQQQQHSFDQSQLLMMGDCYQNLQPKQPMLAHSSPPTSL 2567

  Fly  1425 --------------TGIYDNDLHHSFNSQLQLQNPKASIDLSG 1453
                          :|||||:.  ..:||.|.|....|::::|
Mosquito  2568 THSYEPGGLSSYQQSGIYDNEC--IISSQQQQQQQHQSVEVAG 2608

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fak	NP_001137718.1	B41	24..267	CDD:214604	123/250 (49%)
		FERM_B-lobe	152..257	CDD:271216	67/104 (64%)
		FERM_C_FAK1	263..394	CDD:270011	61/166 (37%)
		PTKc_FAK	450..744	CDD:133187	218/302 (72%)
		Focal_AT	1250..1376	CDD:460992	92/125 (74%)
Fak	XP_061513649.1	None