Protein Alignment Fak and btk

DIOPT Version :10

• Sequence 1: NP_001137718.1
• Gene: Fak / 37233
• FlyBaseID: FBgn0020440
• Length: 1500
• Species: Drosophila melanogaster
• Sequence 2: NP_001123732.1
• Gene: btk / 100170477
• XenbaseID: XB-GENE-6451230
• Length: 649
• Species: Xenopus tropicalis
• Alignment Length: 297
• Identity: 109/297 - (36%)
• Similarity: 165/297 - (55%)
• Gaps: 33/297 - (11%)

  Fly   449 NYELDRALITPSAKIGVGQFGDVYVGTYTLPKLGKGKNLAGNGKNSNSDQRNADSRPDVIQVAIK 513
            ::|:|...:|...::|.||||.|..|.:      :|::                      .||||
 Frog   385 SWEIDPKDLTFLKELGNGQFGVVKYGKW------RGQH----------------------DVAIK 421

  Fly   514 TCKANDDPEKTENFLAEAYIMQKFDHPHIIRLIGICSVM-PIWIVMELAKLGELRAYLKTNSERL 577
            ..|.....|  :.|:.||..|.|..|.::::|.|:|:.. ||:|:.|....|.|..|||....|:
 Frog   422 MIKEGSMSE--DEFIEEAKCMMKLSHQNLVQLYGVCTKQRPIFIITEFLSNGCLLNYLKDLRGRV 484

  Fly   578 SHGTLLKYCYQLSTALSYLESKKFVHRDIAARNVLVSSPTCVKLADFGLSRWVSDQSYYHSTPTV 642
            |.|.||..|..:..|::|||||:::|||:||||.||::...||::||||||:|.|..|..|..:
 Frog   485 SQGDLLSMCSDVCAAMTYLESKQYLHRDLAARNCLVAADGIVKVSDFGLSRYVLDDEYTSSLGS- 548

  Fly   643 ALPIKWMSPESINFRRFTTASDVWMFGVCIWEILMLGVKPFQGVKNSDVILKLENGERLPLPPNC 707
            ..|::|.|||.:.:.||::.||||.|||.:||:..||..|:....|::::.::..|.||..|.|.
 Frog   549 KFPVRWSSPEVLLYCRFSSKSDVWSFGVLMWEVFTLGRMPYDRFTNNEIVEQITRGVRLYRPQNA 613

  Fly   708 PPRLYSLMSQCWAYEPLKRPNFKRIKETLHEILIEDS 744
            ..|:||:|..|||.:...||.|:.:..|:.|:| |||
 Frog   614 TDRVYSIMVSCWAEKADDRPTFRILHNTILEVL-EDS 649

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fak	NP_001137718.1	B41	24..267	CDD:214604
		FERM_B-lobe	152..257	CDD:271216
		FERM_C_FAK1	263..394	CDD:270011
		PTKc_FAK	450..744	CDD:133187	107/294 (36%)
		Focal_AT	1250..1376	CDD:460992
btk	NP_001123732.1	PH_Btk	8..167	CDD:269944
		SH3_BTK	209..264	CDD:212839
		SH2_Tec_Btk	267..370	CDD:198260
		Protein Kinases, catalytic domain	388..638	CDD:473864	102/280 (36%)