Protein Alignment Fak and tnk2

DIOPT Version :10

• Sequence 1: NP_001137718.1
• Gene: Fak / 37233
• FlyBaseID: FBgn0020440
• Length: 1500
• Species: Drosophila melanogaster
• Sequence 2: XP_031757304.1
• Gene: tnk2 / 100124754
• XenbaseID: XB-GENE-984470
• Length: 1151
• Species: Xenopus tropicalis
• Alignment Length: 1172
• Identity: 265/1172 - (22%)
• Similarity: 434/1172 - (37%)
• Gaps: 329/1172 - (28%)

  Fly   462 KIGVGQFGDVYVGTYTLPKLGKGKNLAGNGKNSNSDQRNADSRPDVIQVAIKTCKAN--DDPEKT 524
            |:|.|.||.|..|.:..|          |||              :..||:|..|.:  ..|:..
 Frog   154 KLGDGSFGVVRRGEWNTP----------NGK--------------LFNVAVKCLKTDVLTQPDVL 194

  Fly   525 ENFLAEAYIMQKFDHPHIIRLIGICSVMPIWIVMELAKLGELRAYLKTNSERLSHGTLLKYCYQL 589
            ::|:.|...|...||.::|||.|:....|:.:|.|||.:|.|...|:.|.......||..|..|:
 Frog   195 DDFIREVNAMHSLDHINLIRLYGVVLTHPMKMVTELAPMGSLLDRLRKNQGYFLISTLCHYAIQI 259

  Fly   590 STALSYLESKKFVHRDIAARNVLVSSPTCVKLADFGLSRWV-SDQSYYHSTPTVALPIKWMSPES 653
            :..::|||||:|:|||:||||:|:||...||:.||||.|.: .:..:|.......:|..|.:|||
 Frog   260 ANGMAYLESKRFIHRDLAARNILLSSNDLVKIGDFGLMRALPKNDDHYVMQEHRKVPFAWCAPES 324

  Fly   654 INFRRFTTASDVWMFGVCIWEILMLGVKPFQGVKNSDVILKLE-NGERLPLPPNCPPRLYSLMSQ 717
            :..|.|:.|||.|||||.:||:...|.:|:.|:..|.::.|:: .||||..|.:.|..:|::|.|
 Frog   325 LKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLVRPEDSPQDIYNVMLQ 389

  Fly   718 CWAYEPLKRPNFKRIKETLHE-------------------ILIEDSI--------------NSSE 749
            |||::|..||.|..:::.|.|                   |.:.|.|              .:..
 Frog   390 CWAHKPEDRPTFVALRDFLVEAQPTDMCALQDFQDPDKLHIQMNDVITVIEGRAENYWWRGQNKR 454

  Fly   750 TLK---REQRKVASMSWIGSDDIDIP--------------PSK----PSRV--------MHDPDI 785
            |||   .::..|.|::.:.:.||..|              |:.    |.|:        |..|||
 Frog   455 TLKVGQFQRNTVTSVAGLSAHDISRPLKNSFIHTGHGDTVPAHCWGFPDRIDELYLGNPMDPPDI 519

  Fly   786 TGLMPET---TGLPQTYIIAQNPAVLAKLMMENQKRGINPAA----------YTTPASV------ 831
            .||...|   |.||            ::...|...|...|||          ...|.|.
 Frog   520 LGLDQGTARPTQLP------------SRAKREPPPRPPQPAARVKSKFHGTILRAPCSCPLCAII 572

  Fly   832 --------FNTLAVGLDDSNPNVSLKTTKL------PAADLLKLDPIAE------SERLRSQFSA 876
                    :||:. |.|||   ::|...||      ||..|..:.|.|.      ::|..|...:
 Frog   573 VPLFQEPSYNTVN-GEDDS---ITLGIKKLYLKKPTPAKGLKLVKPSARVTGTKVTDRQLSDIRS 633

  Fly   877 NSSASQLANPLTASVNPHESLNSHQAGMFTGSLPSKSSFVVCPPQTEEHMQAENISNPSVSKVS- 940
            ||...:      ..::..|.|:....|..:             |..|:       :.||::|::
 Frog   634 NSLKEE------ELIDFGEDLSPISPGYLS-------------PAVEQ-------TAPSLAKLAM 672

  Fly   941 -GYSLYGSLERHQPPPAKAMHSKGGSLERHQSLMSAQNLVFYNTKP---PPNCTNTAERSR---- 997
             .:||.     .:.||    .|...||.|.   :....:|.:::||   ||.....|:...
 Frog   673 EAFSLL-----DKTPP----QSPSRSLPRP---LHPTPVVDWDSKPLPAPPAYDEVAQDEDDFEV 725

  Fly   998 -SMERNTYFHAYRQQMKTSIECEALPEEIYDFGGIGLK---TCVSARQQPKFSPMVNVRPAELGQ 1058
             |:..:....|.::::..::...|..:...::|.:..:   .|....:...|.|..:.:...|.|
 Frog   726 CSINSSDVLLAQKEKVTVNLLQRAREKGETNYGYVKEEERYNCRGKLEDNLFLPPKDTKQPSLSQ 790

  Fly  1059 VQ------NTDCMGLQQNIPMDSFGVISPHNLDESLRHQREMERQWMTSGPQSITVNPNISISEG 1117
            ..      ..:|| .:.|:|. |..:.|..:...|:.|..      :|.......:.|.|.|..
 Frog   791 TSEIFEELQQECM-KRLNVPA-STSLASTPSPSTSIMHIN------VTPSEDKPQIPPRIPIPP- 846

  Fly  1118 AACLATLQAEAMGNQGIHNVLGEKLRQQQKDSNSDSEWLIQEELLRSCSIPQGSLNDHQAQMFKL 1182
                                  ..:|:.:.|     .|             .|.|    :..|..
 Frog   847 ----------------------RPVRRNEHD-----RW-------------SGEL----SPAFGA 867

  Fly  1183 DFMSAGPSSLP--DCSNSSSRPMTPNA-------NLSSLKSNHSSADHLSSLTSAEEQMGSNARN 1238
            |.:...|...|  ..|..:||..:|.|       ..|:|.|..|...:||:             :
 Frog   868 DEIGRPPLLPPRDPLSQPTSRTPSPMAFQVGSPQQRSNLCSPLSIGTYLST-------------S 919

  Fly  1239 LGSAVPSRPPNRADDEVYCATTLVVKSIMALSQGVEKANTEGYLELVKNVGVKLRN----LL--- 1296
            .|..:|: ..:.|.|..| ||..|::     :||.:.......|.:||: |.|:.:    ||
 Frog   920 PGKLMPT-TQSFASDPKY-ATPKVIQ-----AQGKDHVKGPCILPIVKD-GKKVSSTHYYLLPER 976

  Fly  1297 -TSVDKISIIF-PAQALKEVQMAHQVLSKDMHELVSAMRLAQQYSDTTLDCEYRKSMLSAAHV-- 1357
             :.:||....| .||:.:|..:...:.:..:..:|........:|....:|..:.::.::..:
 Frog   977 PSYLDKYEKFFKEAQSPEESSVVRSITTATVRPMVHQTDYKANFSSNNSNCSSKSTVKTSCSLQK 1041

  Fly  1358 LAMDAKNLFDVVDSIRQRYQHLFPPSATKETSCSSSFESTSGSIVAEPVNDLGGYIKTSTSGDLL 1422
            :..|..:.....:.||..:.|...||....|...              |.|....:.|......|
 Frog  1042 IVYDGPDCIKNAEKIRLLHSHWSLPSKLLFTHTK--------------VQDTVHGVTTEECQTAL 1092

  Fly  1423 QNTGIYDNDLHHSFNSQLQLQNPKASIDLSGGGSLQRGMSLGLDTTRSTNEPLRIVEETLGSPGE 1487
            ||         |.:|.|..:|..|          :::...|||.|....::.|.:.:..|.:...
 Frog  1093 QN---------HGWNVQKAVQYLK----------VEQLFCLGLKTRIECHKVLEMFDWNLETASS 1138

  Fly  1488 HM 1489
            |:
 Frog  1139 HL 1140

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fak	NP_001137718.1	B41	24..267	CDD:214604
		FERM_B-lobe	152..257	CDD:271216
		FERM_C_FAK1	263..394	CDD:270011
		PTKc_FAK	450..744	CDD:133187	103/304 (34%)
		Focal_AT	1250..1376	CDD:460992	27/136 (20%)
tnk2	XP_031757304.1	SAM_TNK-like	34..95	CDD:188938
		PTKc_Ack_like	153..410	CDD:270636	101/279 (36%)
		SH3_9	418..467	CDD:434066	6/48 (13%)
		GTPase_binding	472..533	CDD:430374	14/60 (23%)
		Inhibitor_Mig-6	883..949	CDD:463294	21/85 (25%)
		UBA_ACK1	1074..1115	CDD:270460	11/73 (15%)
		UBA_TNK1	1102..1141	CDD:270513	9/49 (18%)