Protein Alignment CalpA and RIM13

DIOPT Version :10

• Sequence 1: NP_001286613.1
• Gene: CalpA / 37232
• FlyBaseID: FBgn0012051
• Length: 843
• Species: Drosophila melanogaster
• Sequence 2: NP_013875.1
• Gene: RIM13 / 855186
• SGDID: S000004763
• Length: 727
• Species: Saccharomyces cerevisiae
• Alignment Length: 693
• Identity: 139/693 - (20%)
• Similarity: 208/693 - (30%)
• Gaps: 267/693 - (38%)

  Fly     1 MDDLRGFLRQAGQEFLNAAGEAAMGAAKDVVGSVINEIF---IKKEADT---------KRVLPSI 53
            |:|...|.......:.||.|:::         |:||.:.   :|.|..|         :.|....
Yeast     1 MNDWHEFNAAIKSIYCNAEGDSS---------SIINRLVGLAMKSEDSTFIEAVLVLKENVSKVD 56

  Fly    54 KNMRVQPLQSQSNSTLYYGNLGEKSSSLGPYSEVQDYETILNSCLASGSLFEDPLFPASNESLQF 118
            |.:|...|.|..||..|         ...|.||............|.|:           |.||
Yeast    57 KQLRFLWLTSTINSRFY---------PPIPISEASPVSWNKTEYCAPGT-----------EELQ- 100

  Fly   119 SRRPDRHIEWLRPHEIAENPQFFVEGYSRFDVQQGELGDCWLLAATANLTQESNLFFRVIPAEQS 183
            .|.|.|        ...:|.    |.||....|..::.||.|:|:..|| :..||...:|....|
Yeast   101 RRYPGR--------AKLQNE----EDYSGGIEQCRDVPDCSLVASLINL-RSKNLNLPLIKQISS 152

  Fly   184 FEENYAGIFHFRFWQYGK-----WVDVIIDDRLPT-YNGELMYMHSTEKNEFWSALLEKAYAKLH 242
            .:      :|......|.     .||:   .::|| .:|:.:.:.|.:.::....|.....:|
Yeast   153 TK------YHVNLSFNGSNKRLVTVDI---SQIPTSVDGKQLSLKSNDISDKIGELALLLVSK-- 206

  Fly   243 GSYEALKGGSTCEAMEDFTGGVSEWYDLKEAPGNLFTILQKAAERN-SMMGCSIEPDPNVTEAET 306
            |:| :..|.:........:|.:.|...:...|   |..|.|..:.| .:||.......|    :.
Yeast   207 GTY-STDGSNISIDTYRLSGFLPEITQVNSYP---FEKLWKFHKSNLCLMGAGTGNRSN----DM 263

  Fly   307 PQGLIRGHAYSITKVCLIDIVTPNRQGKIPMIRMRNPWGNEA-------------------EWNG 352
            .:.|:..|.|||     |||...:|     ::::|:| .|.|                   .||
Yeast   264 IKPLVENHDYSI-----IDITYDSR-----LVKLRDP-RNSALNVEISYEQYLKNFKQLYLNWN- 316

  Fly   353 PWSDSSPEWRYIPEEQKAEIGLTFDRDGEF---------------------WM----SFQD---- 388
                   :.:.....|.........|..:|                     |:    ..||
Yeast   317 -------QEKLFKRSQVLHFRYDTSRYNKFSIVADKPLFHLVNNSKVTETVWLLLESHLQDEGSQ 374

  Fly   389 ------FLNHFDRVEICNLSP------------------DSLTE------DQQNSGKRKWEMSM- 422
                  |||......||.:.|                  |:.||      ...|:.......|:
Yeast   375 ENRSVSFLNEAPECIICPIEPPVECGGNHIGLQLVKLRLDAETERLLYCYSTTNNNFSIHSFSVV 439

  Fly   423 -----------------------YEGEWTPGVTAGGCRNFLDT--FWHNPQYIITLVDPDEEDEE 462
                                   ||.|        |..:| ||  |:.||.:.:      |...|
Yeast   440 KEICFQRLKDTKSLFAKVLFSFPYEIE--------GKASF-DTCNFFQNPTFEL------EVHSE 489

  Fly   463 GQCTVIVALMQKNRRSKRNMGMECLT------IGFAIYSLNDREL------EN--RP-QGLNFFR 512
            ....|:             |...|::      |...:|..||.||      :|  :| |||
Yeast   490 QDYQVL-------------MDAACISTSSHDLINIQVYYFNDYELIKPIMFDNHYQPGQGL---- 537

  Fly   513 YKSSVGRSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEF 555
             |..|   |...|.:            |:||.||:.|....||
Yeast   538 -KQDV---PILTNVK------------YMIVCSTYGPPASTEF 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CalpA	NP_001286613.1	Peptidase_C2	104..400	CDD:459889	69/356 (19%)
		Calpain_III	416..569	CDD:238132	39/181 (22%)
		EFh_PEF_CalpA_B	600..843	CDD:320071
		EF-hand motif	600..627	CDD:320071
		EF-hand motif	717..747	CDD:320071
		EF-hand motif	748..778	CDD:320071
		EF-hand motif	784..812	CDD:320071
		EF-hand motif	813..843	CDD:320071
RIM13	NP_013875.1	None