DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CalpA and PEF1

DIOPT Version :9

Sequence 1:	NP_001286613.1	Gene:	CalpA / 37232	FlyBaseID:	FBgn0012051	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_011572.2	Gene:	PEF1 / 852949	SGDID:	S000003290	Length:	335	Species:	Saccharomyces cerevisiae

Alignment Length:	299	Identity:	62/299 - (20%)
Similarity:	117/299 - (39%)	Gaps:	49/299 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   562 ETQ--NNMEENDDHVGYGGKADTITPGFPTPKPIDPQKEGLRRLFDSIAGKDMEVDWMELKRILD 624
            :||  .|..||..| .| |...:.:|.. |..|:||:       ::.||.|.
Yeast    61 QTQYNKNRAENGHH-SY-GSPQSYSPRH-TKTPVDPR-------YNVIAQKP------------- 102

  Fly   625 HSMRDDLPKPVVFNRFSNNMAFETQAAGPG---DDGAGACGLLSLICGPFLKGTPFEEQLGMND- 685
             :.|...|.|..:|..  |.:.:..|:.|.   .:.|....||..:.     ...|:.:..:.|
Yeast   103 -AGRPIPPAPTHYNNL--NTSAQRIASSPPPLIHNQAVPAQLLKKVA-----PASFDSREDVRDM 159

  Fly   686 QSNKRLIGDNPADG-GPVTANAIV-----DETHGFSKDVCRSMVAMLDADKSGKLGFEEFETLLS 744
            |...:|..::...| ..:||..:.     |:...|......:::.:..|.:.|.:...||..|..
Yeast   160 QVATQLFHNHDVKGKNRLTAEELQNLLQNDDNSHFCISSVDALINLFGASRFGTVNQAEFIALYK 224

  Fly   745 EIAKWKAIFKVYDVENTGRVSGFQLREALNSAGYHLNNRVLNVLGHRYG---SRDG---KIAFDD 803
            .:..|:.::...|:..:..:|..:...:|...||.:...|......:|.   :|:|   ::.||.
Yeast   225 RVKSWRKVYVDNDINGSLTISVSEFHNSLQELGYLIPFEVSEKTFDQYAEFINRNGTGKELKFDK 289

  Fly   804 FIMCAVKIKTYIDIFKERDTEKNETATFTLEEWIERTIY 842
            |:...|.:.....:|::.||.:...||...:::|:.|:|
Yeast   290 FVEALVWLMRLTKLFRKFDTNQEGIATIQYKDFIDATLY 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpA	NP_001286613.1	Peptidase_C2	104..400	CDD:279042
		Calpain_III	418..565	CDD:279416	2/4 (50%)
		EFh	719..765	CDD:238008	7/45 (16%)
PEF1	NP_011572.2	EFh_PEF_Group_I	161..329	CDD:320055	33/168 (20%)
		EF-hand motif	161..190	CDD:320055	4/28 (14%)
		EF-hand motif	198..227	CDD:320055	5/28 (18%)
		EF-hand motif	228..257	CDD:320055	4/28 (14%)
		EF-hand motif	264..298	CDD:320055	8/33 (24%)
		EF-hand motif	300..328	CDD:320055	7/27 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	46	1.000	Domainoid score	I3060
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910