DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpA and CAPNS2

DIOPT Version :9

Sequence 1:	NP_001286613.1	Gene:	CalpA / 37232	FlyBaseID:	FBgn0012051	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_115706.1	Gene:	CAPNS2 / 84290	HGNCID:	16371	Length:	248	Species:	Homo sapiens

Alignment Length:	296	Identity:	82/296 - (27%)
Similarity:	135/296 - (45%)	Gaps:	68/296 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   553 GEFIIRVFSETQNNMEENDDHVG--YGGKADTITPGFP---TPKPIDPQKEGLRRLFDSIAGKDM 612
            ||.:..:|.......|....::|  .||..:.|:....   ||:|...|:.     |.|:...:.
Human    16 GEALGGLFGGGGQRREGGGRNIGGIVGGIVNFISEAAAAQYTPEPPPTQQH-----FTSVEASES 75

  Fly   613 EVDWMELKRILDHSMRDDLPKPVVFNRFSNNMAFETQAAGPGDDGAGACGLLSLICGPFLKGTPF 677
            |    |::|.....                     ||.||| |...||..|::::
Human    76 E----EVRRFRQQF---------------------TQLAGP-DMEVGATDLMNIL---------- 104

  Fly   678 EEQLGMNDQSNKRLIGDNPADGGPVTANAIVDETHGFSKDVCRSMVAMLDADKSGKLGFEEFETL 742
                      ||.|......            :|.|||.|.|||:|:::|:|.:||||||||:.|
Human   105 ----------NKVLSKHKDL------------KTDGFSLDTCRSIVSVMDSDTTGKLGFEEFKYL 147

  Fly   743 LSEIAKWKAIFKVYDVENTGRVSGFQLREALNSAGYHLNNRVLNVLGHRYGSRDGKIAFDDFIMC 807
            .:.|.||:.::|.||.:::|.:...|||.||.:||:.||.::..::..||.:.||.:.|::||.|
Human   148 WNNIKKWQCVYKQYDRDHSGSLGSSQLRGALQAAGFQLNEQLYQMIVRRYANEDGDMDFNNFISC 212

  Fly   808 AVKIKTYIDIFKERDTEKNETATFTLEEWIERTIYS 843
            .|::......||..|.:::.....:::||::.|:||
Human   213 LVRLDAMFRAFKSLDRDRDGLIQVSIKEWLQLTMYS 248

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpA	NP_001286613.1	Peptidase_C2	104..400	CDD:279042
		Calpain_III	418..565	CDD:279416	3/11 (27%)
		EFh	719..765	CDD:238008	22/45 (49%)
CAPNS2	NP_115706.1	EFh_PEF_CPNS1_2	80..248	CDD:320063	64/221 (29%)
		EF-hand motif	80..108	CDD:320063	12/69 (17%)
		EF-hand motif	122..152	CDD:320063	16/29 (55%)
		EF-hand motif	153..183	CDD:320063	12/29 (41%)
		EF-hand motif	189..217	CDD:320063	9/27 (33%)
		EF-hand motif	218..248	CDD:320063	6/29 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910