DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpA and Capn6

DIOPT Version :9

Sequence 1:	NP_001286613.1	Gene:	CalpA / 37232	FlyBaseID:	FBgn0012051	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_113996.2	Gene:	Capn6 / 83685	RGDID:	70960	Length:	641	Species:	Rattus norvegicus

Alignment Length:	520	Identity:	187/520 - (35%)
Similarity:	282/520 - (54%)	Gaps:	55/520 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 LGPYSEV---QDYETILNSCLASGSLFEDPLFPASNESLQFSRRPDRHIEWLRPHEIAENPQFFV 142
            :||..::   |.|:.:...|:..|.||.||.|...|:||.|:|.....:.|.||.:|:::|...|
  Rat     1 MGPPLKLFKNQKYQELKQDCMKDGRLFCDPTFLPENDSLFFNRLLPGKVVWKRPQDISDDPHLIV 65

  Fly   143 EGYSRFDVQQGELGDCWLLAATANLTQESNLFFRVIP--AEQSFE----ENYAGIFHFRFWQYGK 201
            ...|...:.||.||:..:::|.:.|..:.:.:.:.||  .||.::    |.|||||.||||.:|:
  Rat    66 GNISNHQLIQGRLGNKAMISAFSCLAVQESHWTKAIPNHKEQEWDPRKPEKYAGIFRFRFWHFGE 130

  Fly   202 WVDVIIDDRLPTYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCEAMEDFTGGVSE 266
            |.:|:|||.|||.||:|::..||..||||:||||||||||.|.||||.|.:..:.:.||||.::|
  Rat   131 WTEVVIDDLLPTINGDLVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGLTITDIIMDFTGTLAE 195

  Fly   267 --------WYDLKEAPGNLFTILQKAAERNSMMGCSIE-PDPNVTEAETPQGLIRGHAYSITKV- 321
                    :.||.|....||..|.|...:..::.|||| |.....|.||..||::|:.|::|.:
  Rat   196 IIDMQKGRYTDLVEEKYKLFGELYKTFTKGGLISCSIESPSQEEQEVETDWGLLKGYTYTMTDIR 260

  Fly   322 ------CLIDIVTPNRQGKIPMIRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFDRDG 380
                  .|:::.:..   |:.|:|:|||.|.: ||:||||:.|.||:.:....:..:||....||
  Rat   261 KLRLGERLVEVFSTE---KLYMVRLRNPLGRQ-EWSGPWSEISEEWQQLTVTDRKNLGLVMSDDG 321

  Fly   381 EFWMSFQDFLNHFDRVEICNLSPDSLTEDQQNSGKRKWEMSMYEGEWT----PGVT-AGGCRNFL 440
            |||||.:||.::|.::.:|        .:..|....:.|:....|.||    |.:. :|||.|..
  Rat   322 EFWMSLEDFCHNFHKLNVC--------RNVNNPVFGRKELESVVGCWTVDDDPLMNRSGGCYNNR 378

  Fly   441 DTFWHNPQYIITLVDPDEEDEEGQCTVIVALMQKNRRSKRNMGM-ECLTIGFAIYSLNDRELENR 504
            |||..|||||.|:      .|:|. .||::|.||:.|:.|.||. :...|||.::.:.    .||
  Rat   379 DTFLQNPQYIFTV------PEDGH-KVIMSLQQKDLRTYRRMGRPDNYIIGFELFKVE----MNR 432

  Fly   505 PQGLNFFRYKSSVGRSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETQNNMEE 569
            ...|:....:...|.|. :|:||.|.....|..|:|::||:.|......||::|:|||....:.|
  Rat   433 RFRLHHLYIQERAGTST-YIDTRTVFLSKYLKKGNYVLVPTMFQHGRTSEFLLRIFSEVPVQLRE 496

Fly 570 569
Rat 497 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpA	NP_001286613.1	Peptidase_C2	104..400	CDD:279042	124/317 (39%)
		Calpain_III	418..565	CDD:279416	53/152 (35%)
		EFh	719..765	CDD:238008
Capn6	NP_113996.2	CysPc	13..351	CDD:128526	130/349 (37%)
		Domain III	344..495		54/162 (33%)
		Calpain_III	349..497	CDD:238132	54/160 (34%)
		C2_Calpain	514..639	CDD:176011
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820