DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CalpA and CAPNS1

DIOPT Version :9

Sequence 1:	NP_001286613.1	Gene:	CalpA / 37232	FlyBaseID:	FBgn0012051	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	XP_005259352.1	Gene:	CAPNS1 / 826	HGNCID:	1481	Length:	322	Species:	Homo sapiens

Alignment Length:	284	Identity:	77/284 - (27%)
Similarity:	108/284 - (38%)	Gaps:	99/284 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   575 GYGGKADTITPGFPT----------PKPIDP-------------QKEGLRRLFDSIAGKDMEVDW 616
            |.||.|..|..|..:          |:|..|             :....||||..:||.||||..
Human    53 GGGGTAMRILGGVISAISEAAAQYNPEPPPPRTHYSNIEANESEEVRQFRRLFAQLAGDDMEVSA 117

  Fly   617 MELKRILDHSMRDDLPKPVVFNRFSNNMAFETQAAGPGDDGAGACGLLSLICGPFLKGTPFEEQL 681
            .||..||:.          |..|.                             |.||
Human   118 TELMNILNK----------VVTRH-----------------------------PDLK-------- 135

  Fly   682 GMNDQSNKRLIGDNPADGGPVTANAIVDETHGFSKDVCRSMVAMLDADKSGKLGFEEFETLLSEI 746
                                         |.||..|.||||||::|:|.:||||||||:.|.:.|
Human   136 -----------------------------TDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNI 171

  Fly   747 AKWKAIFKVYDVENTGRVSGFQLREALNSAGYHLNNRVLNVLGHRYGSRDGKIAFDDFIMCAVKI 811
            .:|:||:|.:|.:.:|.:...:|..|..:||:|||..:.|::..||....|.:.||:||.|.|::
Human   172 KRWQAIYKQFDTDRSGTICSSELPGAFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRL 236

  Fly   812 KTYIDIFKERDTEKNETATFTLEE 835
            ......||..|.:........::|
Human   237 DAMFRAFKSLDKDGTGQIQVNIQE 260

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpA	NP_001286613.1	Peptidase_C2	104..400	CDD:279042
		Calpain_III	418..565	CDD:279416
		EFh	719..765	CDD:238008	24/45 (53%)
CAPNS1	XP_005259352.1	EFh_PEF_CPNS1_2	100..260	CDD:320063	67/235 (29%)
		EF-hand motif	100..128	CDD:320063	14/37 (38%)
		EF-hand motif	142..172	CDD:320063	18/29 (62%)
		EF-hand motif	173..203	CDD:320063	9/29 (31%)
		EF-hand motif	209..237	CDD:320063	10/27 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910