DRSC/TRiP Functional Genomics Resources

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Protein Alignment CalpA and CAPN2

DIOPT Version :10

Sequence 1:NP_001286613.1 Gene:CalpA / 37232 FlyBaseID:FBgn0012051 Length:843 Species:Drosophila melanogaster
Sequence 2:NP_001739.3 Gene:CAPN2 / 824 HGNCID:1479 Length:700 Species:Homo sapiens


Alignment Length:785 Identity:327/785 - (41%)
Similarity:457/785 - (58%) Gaps:125/785 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    76 EKSSSLGPYSEV-----QDYETILNSCLASGSLFEDPLFPASNESLQFSR-----RPDRHIEWLR 130
            |.:..||.:...     ||||.:.|.||.:|:||:||.|||...:|.|..     ...|.|||.|
Human    13 EAAEGLGSHDRAIKYLNQDYEALRNECLEAGTLFQDPSFPAIPSALGFKELGPYSSKTRGIEWKR 77

  Fly   131 PHEIAENPQFFVEGYSRFDVQQGELGDCWLLAATANLTQESNLFFRVIPAEQSFEENYAGIFHFR 195
            |.||..:|||.:.|.:|.|:.||.|||||||||.|:||....:..||:|..|||:|||||||||:
Human    78 PTEICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIFHFQ 142

  Fly   196 FWQYGKWVDVIIDDRLPTYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCEAMEDF 260
            |||||:||:|::||||||.:|||:::||.|.:|||||||||||||::|.||||.||:|.|..|||
Human   143 FWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGATTEGFEDF 207

  Fly   261 TGGVSEWYDLKEAPGNLFTILQKAAERNSMMGCSIEPDPNVT-----EAETPQGLIRGHAYSITK 320
            |||::|||:||:.|.|||.|:|||.::.|::||||:    :|     ||.|.|.|::|||||:|.
Human   208 TGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSID----ITSAADSEAITFQKLVKGHAYSVTG 268

  Fly   321 VCLIDIVTPNRQGKI-PMIRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFDRDGEFWM 384
            .   :.|..|  |.: .:||:||||| |.||.|.|:|:.|.|..|..|::..:....: ||||||
Human   269 A---EEVESN--GSLQKLIRIRNPWG-EVEWTGRWNDNCPSWNTIDPEERERLTRRHE-DGEFWM 326

  Fly   385 SFQDFLNHFDRVEICNLSPDSLTEDQQNSGKRKWEMSMYEGEWTPGVTAGGCRNFLDTFWHNPQY 449
            ||.|||.|:.|:|||||:||:||.|..    :||:::..:|.|..|.|||||||:.:|||.||||
Human   327 SFSDFLRHYSRLEICNLTPDTLTSDTY----KKWKLTKMDGNWRRGSTAGGCRNYPNTFWMNPQY 387

  Fly   450 IITLVDPDEEDEEGQ--CTVIVALMQKNRRSKRNMGMECLTIGFAIYSLNDRELENRPQ---GLN 509
            :|.|.:.||::|:|:  ||.:|.|:||:||.:|.||.:..||||.||.:.: ||..:..   ..|
Human   388 LIKLEEEDEDEEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPE-ELSGQTNIHLSKN 451

  Fly   510 FFRYKSSVGRSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETQNNMEENDDHV 574
            ||....:..||..|||.|||..|||||||.|::|||||:||::|:|.||||||.:.:.:..||.:
Human   452 FFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKKADYQAVDDEI 516

  Fly   575 GYGGKADTITPGFPTPKPIDPQKEGLRRLFDSIAGKDMEVDWMELKRILDH--SMRDDLPKPVVF 637
            ....:...|:.        |...:|.||||..:||:|.|:...||:.||..  :.|.|:      
Human   517 EANLEEFDISE--------DDIDDGFRRLFAQLAGEDAEISAFELQTILRRVLAKRQDI------ 567

  Fly   638 NRFSNNMAFETQAAGPGDDGAGACGLLSLICGPFLKGTPFEEQLGMNDQSNKRLIGDNPADGGPV 702
                                                                             
Human   568 ----------------------------------------------------------------- 567

  Fly   703 TANAIVDETHGFSKDVCRSMVAMLDADKSGKLGFEEFETLLSEIAKWKAIFKVYDVENTGRVSGF 767
                   ::.|||.:.|:.||.|||:|.|||||.:||..|.::|.|::.|::..||:.:|.::.:
Human   568 -------KSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSY 625

  Fly   768 QLREALNSAGYHLNNRVLNVLGHRYGSRDGKIAFDDFIMCAVKIKTYIDIFKERDTEKNETATFT 832
            ::|:||..||:.:..::..|:..|:......|.||:|:.|.|:::|...|||:.|.|...|....
Human   626 EMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKIFKQLDPENTGTIELD 690

  Fly   833 LEEWI 837
            |..|:
Human   691 LISWL 695

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CalpANP_001286613.1 Peptidase_C2 104..400 CDD:459889 164/306 (54%)
Calpain_III 416..569 CDD:238132 78/157 (50%)
EFh_PEF_CalpA_B 600..843 CDD:320071 60/240 (25%)
EF-hand motif 600..627 CDD:320071 12/28 (43%)
EF-hand motif 717..747 CDD:320071 15/29 (52%)
EF-hand motif 748..778 CDD:320071 9/29 (31%)
EF-hand motif 784..812 CDD:320071 8/27 (30%)
EF-hand motif 813..843 CDD:320071 9/25 (36%)
CAPN2NP_001739.3 Peptidase_C2 46..342 CDD:459889 164/306 (54%)
Domain III 345..514 83/173 (48%)
Calpain_III 354..512 CDD:238132 78/158 (49%)
Linker 515..529 1/21 (5%)
Domain IV 530..700 61/244 (25%)
EFh_PEF_CAPN2 533..700 CDD:320074 61/241 (25%)
EF-hand motif 533..561 CDD:320074 13/27 (48%)
EF-hand motif 576..605 CDD:320074 15/28 (54%)
EF-hand motif 606..636 CDD:320074 9/29 (31%)
EF-hand motif 642..670 CDD:320074 8/27 (30%)
EF-hand motif 672..700 CDD:320074 8/24 (33%)

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