DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CalpA and capn12

DIOPT Version :9

Sequence 1:	NP_001286613.1	Gene:	CalpA / 37232	FlyBaseID:	FBgn0012051	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	XP_005173727.1	Gene:	capn12 / 799247	ZFINID:	ZDB-GENE-050419-245	Length:	717	Species:	Danio rerio

Alignment Length:	816	Identity:	260/816 - (31%)
Similarity:	404/816 - (49%)	Gaps:	186/816 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 QDYETILNSCLASGSLFEDPLFPASNESLQFSRRPD--RHIEWLRPHEIAENPQFFVEG-YSRFD 149
            ||||.:|.:||.|..||.|.:|.|:..||.....||  :.::||||.||..| ..|||| ....|
Zfish    16 QDYEVLLQTCLKSAVLFSDSVFAANQSSLGLPADPDPKKAVKWLRPKEITSN-AVFVEGTMGTTD 79

  Fly   150 VQQGELGDCWLLAATANLTQESNLFFRVIPAEQSFEENYAGIFHFRFWQYGKWVDVIIDDRLPTY 214
            :.||:||:||||||.:.||....||.:|:||.||..|:|||||.|:|||||:||:|::|||||..
Zfish    80 ICQGQLGNCWLLAALSCLTMHPTLFVKVVPAGQSLSESYAGIFRFKFWQYGEWVEVVVDDRLPVR 144

  Fly   215 NGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCEAMEDFTGGVSEWYDL---KEAPGN 276
            .|.|::.:|...|||||||:|||||||.|||.:||||...|.|||||||::  |.|   ...|..
Zfish   145 EGRLLFSYSRTSNEFWSALVEKAYAKLIGSYGSLKGGIISEGMEDFTGGIA--YSLPVSSRPPRM 207

  Fly   277 LFTILQKAAERNSMMGCSIEPDPNVTEAE-----TPQGLIRGHAYSITKVCLIDIVTPNRQGKIP 336
            |:..:..|..|||::.|.|    :.|..:     ||:|||:||||:||:.           ||:.
Zfish   208 LWKAITAALARNSLLSCFI----HATTVKDIGTVTPEGLIKGHAYAITET-----------GKVK 257

  Fly   337 -------MIRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFDRDGEFWMSFQDFLNHFD 394
                   ::|:||||| ..|:.|||||...:|.::...:|.::.|....|||||:|.:||...::
Zfish   258 KASEEVFLLRLRNPWG-FVEYCGPWSDKCKDWDFVDNTEKTKLELAKVEDGEFWISIEDFCRFYN 321

  Fly   395 RVEICNLSPDSLT-EDQQNSGKRKWEMSMYEGEWTPGVTAGGCRNFLDTFWHNPQYIITLVDPDE 458
            .||:|::.|||:: |:.:::....|.:|:::|.|.|..:|||.|.:..:||.||||.:.|.:.|.
Zfish   322 TVEMCSVDPDSMSGEESEDTSTSSWTLSLHQGTWVPMCSAGGSRRYPKSFWKNPQYQMILSEKDV 386

  Fly   459 ED------EEG-----------------------------QCTVIVALMQKNRRSKRNMGMECLT 488
            :|      |||                             :|||:|.|:||.||.|..:..  |.
Zfish   387 DDHDYGEGEEGDDGGDGEEDEDVSLLPPVSKTSKPGEKKKKCTVLVELLQKYRRQKDKVNF--LY 449

  Fly   489 IGFAIYSLNDRELENRPQGLN--FFRYKSSVGRSPHFINTREVCARFKLPPGHYLIVPSTFDPNE 551
            |.|.||.: ..||::.|..|:  ||....::.||..:.:.|.|..:..|.||.|:|:.||:.||:
Zfish   450 IAFHIYKV-PPELKDSPGSLDQQFFSSNRAISRSGKYRSIRSVWRKVHLEPGSYVILASTYRPNQ 513

  Fly   552 EGEFIIRVFSETQNNMEENDDHVGYGGKADTITPGFP---------TPKPIDPQKE-GLRRLFDS 606
            :|||.:|::::|.|.....|               ||         ..||:.|:.: .:::.|:.
Zfish   514 QGEFFLRIYTKTGNIQGFQD---------------FPCTNNYSAMVMSKPVLPEDQYRVQKWFEE 563

  Fly   607 IAGKDMEVDWMELKRILDHSMRDDLPKPVVFNRFSNNMAFETQAAGPGDDGAGACGLLSLICGPF 671
            .||.|..|:.::...::
Zfish   564 KAGSDERVNAVQFMNLV------------------------------------------------ 580

  Fly   672 LKGTPFEEQLGMNDQSNKRLIGDNPADGGPVTANAIVDETHGFSKDVCRSMVAMLDADKSGKLGF 736
                                             |:::::.:....:.||.::...|....|:|..
Zfish   581 ---------------------------------NSVLEKDYELPLETCRQLIFGEDTGGRGRLDR 612

  Fly   737 EEFETLLSEIAKWKAIFKVYDVENTGRVSGFQLREALNSAGYHLNNRVLNVLGHRYGSRDGKIAF 801
            .:.|.|||.:...::||..:|.:::|.:|.|:|..|||:||...::.|:.:|..|:|:.:..:.|
Zfish   613 AQAEKLLSSLRNLQSIFFQFDEDSSGTMSPFELSLALNAAGVECDSVVVQMLWERFGAGEQYLPF 677

  Fly   802 DDFIMCAVKIKTYIDIFKERDTEKNETATFTLEEWI 837
            ..|:.|..:::...|:: |.:|.: |.....:..|:
Zfish   678 YGFVSCVARLQVLFDLY-EAETNQ-EVKDKGINAWL 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpA	NP_001286613.1	Peptidase_C2	104..400	CDD:279042	140/313 (45%)
		Calpain_III	418..565	CDD:279416	60/183 (33%)
		EFh	719..765	CDD:238008	13/45 (29%)
capn12	XP_005173727.1	Peptidase_C2	32..327	CDD:279042	140/313 (45%)
capn12	XP_005173727.1	Calpain_III	346..527	CDD:279416	60/183 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	78	1.000	Domainoid score	I8692
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.880