DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpA and Capn9

DIOPT Version :9

Sequence 1:	NP_001286613.1	Gene:	CalpA / 37232	FlyBaseID:	FBgn0012051	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	XP_006531467.1	Gene:	Capn9 / 73647	MGIID:	1920897	Length:	718	Species:	Mus musculus

Alignment Length:	792	Identity:	325/792 - (41%)
Similarity:	460/792 - (58%)	Gaps:	132/792 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 YSEVQDYETILNSCLASGSLFEDPLFPASNESLQFSRRPDRHIEWLRPHEIAENPQFFVEGYSRF 148
            :|..|.:|.:...||.||:||||..|||||.||.:|.||.....|.||.||.|.|:|.:.|.:|.
Mouse    23 HSSGQSFEQLRQGCLQSGTLFEDADFPASNVSLFYSERPQVPFVWKRPGEIVEKPEFILGGATRT 87

  Fly   149 DVQQGELGDCWLLAATANLTQESNLFFRVIPAEQSFEENYAGIFHFRFWQYGKWVDVIIDDRLPT 213
            |:.||||||||||||.|:||.......||:|.:|.|...|||||||:|||:.:|:||:|||||||
Mouse    88 DICQGELGDCWLLAAIASLTLNQKALTRVVPQDQGFGSGYAGIFHFQFWQHSEWLDVVIDDRLPT 152

  Fly   214 YNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCEAMEDFTGGVSEWYDLKEAPGNLF 278
            :...|:::||.:.|||||||||||||||:||||||||||..||||||||||:|.:.::|||.:.|
Mouse   153 FKDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTGGVAENFQIREAPEDFF 217

  Fly   279 TILQKAAERNSMMGCSIEP-DPNVTEAETPQGLIRGHAYSITKVCLIDIVTPNRQGKIPMIRMRN 342
            .||:||.:|.|::||||:. :.:.:||.|..|||:||||::|.   :|.|..:.| :|.:||:||
Mouse   218 EILEKALKRGSLLGCSIDTLNASESEARTSLGLIKGHAYTVTG---LDQVNFHGQ-RIKLIRVRN 278

  Fly   343 PWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFDRDGEFWMSFQDFLNHFDRVEICNLSPDSLT 407
            ||| :.||||||||||||||.:..|::..:|.|...||||||:|:||..|||:||||||:||:|
Mouse   279 PWG-QVEWNGPWSDSSPEWRSVDLEEQKRLGHTALDDGEFWMAFKDFKIHFDKVEICNLTPDAL- 341

  Fly   408 EDQQNSGKRKWEMSMYEGEWTPGVTAGGCRNFLDTFWHNPQYIITLVDPDEEDEEGQCTVIVALM 472
               ::|...:||:::::|.|..|.|||||||||||||.|||..::|.:.| |.:|| ||.:.|||
Mouse   342 ---EDSALHRWEVTIHQGSWVRGSTAGGCRNFLDTFWTNPQIKLSLTERD-EGQEG-CTFLAALM 401

  Fly   473 QKNRRSKRNMGMECLTIGFAIYSLNDRE--LENRPQGLNFFRYKSSVGRSPHFINTREVCARFKL 535
            ||:||..:..|...||||:|||...|::  |..     :||||.:|:.||..|||.|||..||:|
Mouse   402 QKDRRRLKRFGANMLTIGYAIYQCPDKDGHLSR-----DFFRYHASLARSKTFINLREVSERFQL 461

  Fly   536 PPGHYLIVPSTFDPNEEGEFIIRVFSETQNNMEENDDHVGYGGKADTITPGFPTPKPIDPQKE-- 598
            |||.|:::||||:|::|.:|.:|:|||.:....:.|:::      |...|..|.|.|.:.:.|
Mouse   462 PPGDYILIPSTFEPHQEADFCLRIFSEKRAVTRDLDENI------DIDLPELPKPTPQEEETEEE 520

  Fly   599 -GLRRLFDSIAGKDMEVDWMELKRILDHSMRDDLPKPVVFNRFSNNMAFETQAAGPGDDGAGACG 662
             ..|.||..:||:||||...||:.:|:..::.  ...:.|.|.|
Mouse   521 QQFRALFQRVAGEDMEVSAEELEYVLNAVLQK--KTALKFKRLS--------------------- 562

  Fly   663 LLSLICGPFLKGTPFEEQLGMNDQSNKRLIGDNPADGGPVTANAIVDETHGFSKDVCRSMVAMLD 727
            |||                                                     ||::::::|
Mouse   563 LLS-----------------------------------------------------CRNIISLMD 574

  Fly   728 ADKSGKLGFEEFETLLSEIAKW-KA---------------------------IFKVYDVENTGRV 764
            ...:|||.||||.....::..| ||                           :|..:||:.:|.:
Mouse   575 TSGNGKLEFEEFRVFWDKLKHWMKAAVTPGQLPAATGPWALTSPCSTPWSQDLFLQFDVDKSGTM 639

  Fly   765 SGFQLREALNSAGYHLNNRVLNVLGHRYGSRDGKIAFDDFIMCAVKIKTYIDIFKERDTEKNETA 829
            |.::||.||.:||:.|...:|.::..||...|.::.|||::.|.|:::....:|:....:..:..
Mouse   640 SSYELRTALKAAGFQLGGHLLQLIVLRYADEDLQLDFDDYLNCLVRLENASRVFQSLSVKNKDFI 704

  Fly   830 TFTLEEWIERTI 841
            ...:.|:|..|:
Mouse   705 HLNINEFISLTM 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpA	NP_001286613.1	Peptidase_C2	104..400	CDD:279042	171/296 (58%)
		Calpain_III	418..565	CDD:279416	76/148 (51%)
		EFh	719..765	CDD:238008	17/73 (23%)
Capn9	XP_006531467.1	Peptidase_C2	43..335	CDD:366222	171/296 (58%)
		Calpain_III	347..496	CDD:238132	76/155 (49%)
		EFh_PEF	523..718	CDD:355382	56/270 (21%)
		EF-hand motif	523..550	CDD:320054	12/26 (46%)
		EF-hand motif	565..594	CDD:320054	11/81 (14%)
		EF-hand motif	595..653	CDD:320054	13/57 (23%)
		EF-hand motif	659..687	CDD:320054	9/27 (33%)
		EF-hand motif	689..718	CDD:320054	4/28 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833685
Domainoid	1	1.000	357	1.000	Domainoid score	I968
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38208
Inparanoid	1	1.050	640	1.000	Inparanoid score	I814
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	1	1.000	-	-		mtm8819
orthoMCL	1	0.900	-	-		OOG6_100404
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2435
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.830