DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CalpA and capn8.1

DIOPT Version :9

Sequence 1:	NP_001286613.1	Gene:	CalpA / 37232	FlyBaseID:	FBgn0012051	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	XP_031757616.1	Gene:	capn8.1 / 733929	XenbaseID:	XB-GENE-920785	Length:	1515	Species:	Xenopus tropicalis

Alignment Length:	775	Identity:	323/775 - (41%)
Similarity:	448/775 - (57%)	Gaps:	124/775 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 QDYETILNSCLASGSLFEDPLFPASNESLQFSR-----RPDRHIEWLRPHEIAENPQFFVEGYSR 147
            ||:|.:...|||||:||:|..|||...:|.|:.     ...:.:.|.||.||..||||.|:|.:|
Frog    31 QDFEKLRAQCLASGTLFKDEEFPACPSALGFNELGPGSPKTQGVIWKRPSEICPNPQFIVDGATR 95

  Fly   148 FDVQQGELGDCWLLAATANLTQESNLFFRVIPAEQSFEENYAGIFHFRFWQYGKWVDVIIDDRLP 212
            .|::||.|||||||||.|:||.:::|..:|:|..|||:::|||||||||||||:||||::|||||
Frog    96 GDIRQGALGDCWLLAAIASLTLDADLVAQVVPENQSFQKDYAGIFHFRFWQYGEWVDVVVDDRLP 160

  Fly   213 TYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCEAMEDFTGGVSEWYDLKEAPGNL 277
            |.||.|:::||.|.:||||||||||||||:||||||.||||.|..||||||::|.|:|::||.:|
Frog   161 TKNGNLVFVHSAEGDEFWSALLEKAYAKLNGSYEALSGGSTIEGFEDFTGGIAEVYELRKAPSDL 225

  Fly   278 FTILQKAAERNSMMGCSIE-PDPNVTEAETPQGLIRGHAYSITKVCLIDIVTPNRQGKIPMIRMR 341
            |.|:|||....|::||||: .:...|||.|.:.|::|||||:|..  .:::...||.|  :||:|
Frog   226 FQIIQKALRAESLLGCSIDITNAYDTEAITSRKLVKGHAYSVTGA--EEVLYRGRQEK--LIRVR 286

  Fly   342 NPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFDRDGEFWMSFQDFLNHFDRVEICNLSPDSL 406
            |||| |.||.|||||::|||.||..:.||.:....| ||||||:|.|||..:.|:||||||||:|
Frog   287 NPWG-EVEWTGPWSDTAPEWNYIDPKVKAALDKQSD-DGEFWMAFSDFLREYSRLEICNLSPDTL 349

  Fly   407 TEDQQNSGKRKWEMSMYEGEWTPGVTAGGCRNFLDTFWHNPQYIITLVDPDEE----DEEGQCTV 467
            |..:|:    ||.:::|.|.|..|.|||||:|:..|||.|||:.|.|.|||.|    ::|..|||
Frog   350 TNTEQH----KWNITLYNGSWARGSTAGGCQNYPATFWTNPQFRIKLDDPDHEHQGSNQEPCCTV 410

  Fly   468 IVALMQKNRRSKRNMGMECLTIGFAIYSLNDRELENRPQ---GLNFFRYKSSVGRSPHFINTREV 529
            ||.|||||||.|:.||.:.|:||::::.: ..:|:|...   |.:||:...:..||..:||.|||
Frog   411 IVGLMQKNRRRKKKMGEDLLSIGYSLFKI-PNQLQNHTDDHLGRDFFQKTPTAARSDTYINVREV 474

  Fly   530 CARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETQNNMEENDDHVGYGGKADTITPGFPTPKPID 594
            ..||.||.|.||||||||:|.:.|:|.:|||||.:....|..|.|              ..||.:
Frog   475 SNRFHLPVGDYLIVPSTFEPFKNGDFCLRVFSEKEAKSLEVGDVV--------------IAKPYE 525

  Fly   595 PQ------KEGLRRLFDSIAGKDMEVDWMELKRILDH--SMRDDLPKPVVFNRFSNNMAFETQAA 651
            |:      .:..:.:||.:||...|:|..||:.||:.  |.|.||
Frog   526 PKISNKDVTDEFKNIFDKLAGDKEEIDAKELQTILNKLISKRPDL-------------------- 570

  Fly   652 GPGDDGAGACGLLSLICGPFLKGTPFEEQLGMNDQSNKRLIGDNPADGGPVTANAIVDETHGFSK 716
                                                                      .::||:.
Frog   571 ----------------------------------------------------------RSNGFTV 577

  Fly   717 DVCRSMVAMLDADKSGKLGFEEFETLLSEIAKWKAIFKVYDVENTGRVSGFQLREALNSAGYHLN 781
            :.||.|:::.|.|.:..|...||..|..:|.|:.||:...|.:.:|.:...:||.||..||:.||
Frog   578 NTCREMISLQDMDGTATLSLLEFRILWLKIQKYLAIYLKADSDRSGTMDAHELRAALQEAGFTLN 642

  Fly   782 NRVLNVLGHRYGSRDGKIAFDDFIMCAVKIKTYIDIFKERDTEKNETATFTLEEWIERTI 841
            |::...:..||.|.:..|.||.||.|.::::|...:|:..|..|......:|:||:..|:
Frog   643 NKIQQSIVLRYASDELTINFDSFIACMMRLETLFKMFQMLDKSKKGVVELSLQEWLCATL 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpA	NP_001286613.1	Peptidase_C2	104..400	CDD:279042	166/301 (55%)
		Calpain_III	418..565	CDD:279416	75/153 (49%)
		EFh	719..765	CDD:238008	15/45 (33%)
capn8.1	XP_031757616.1	Peptidase_C2	47..343	CDD:395523	166/301 (55%)
		Calpain_III	355..515	CDD:238132	76/164 (46%)
		EFh_PEF_CAPN8	536..702	CDD:320066	56/243 (23%)
		Peptidase_C2	809..1106	CDD:395523
		Calpain_III	1127..1268	CDD:395848
		EFh_PEF	1298..1515	CDD:355382
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	361	1.000	Domainoid score	I950
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	643	1.000	Inparanoid score	I801
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	1	1.000	-	-		mtm9483
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060