DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpA and CAPN5

DIOPT Version :9

Sequence 1:	NP_001286613.1	Gene:	CalpA / 37232	FlyBaseID:	FBgn0012051	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	XP_011543527.1	Gene:	CAPN5 / 726	HGNCID:	1482	Length:	680	Species:	Homo sapiens

Alignment Length:	519	Identity:	214/519 - (41%)
Similarity:	306/519 - (58%)	Gaps:	52/519 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 SSLGPYSEVQDYETILNSCLASGSLFEDPLFPASNESLQFSRRPDRHIEWLRPHEIAENPQFFVE 143
            |.:.|| |.|:|..:...|.....|||||||||:::||.:...|...:.|.||..|.|:|:.||:
Human    43 SCVKPY-EDQNYSALRRDCRRRKVLFEDPLFPATDDSLYYKGTPGPAVRWKRPKGICEDPRLFVD 106

  Fly   144 GYSRFDVQQGELGDCWLLAATANLTQESNLFFRVIP--AEQSFEEN----YAGIFHFRFWQYGKW 202
            |.|..|:.||::|:||.:||.::|....:|:.:|||  .||.::..    |||||||.||::|:|
Human   107 GISSHDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWDPEKPNAYAGIFHFHFWRFGEW 171

  Fly   203 VDVIIDDRLPTYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCEAMEDFTGGVSEW 267
            |||:|||||||.|.:|:|.||..:||||.||:|||||||.|.|:||.||:|.:|:.||||||||.
Human   172 VDVVIDDRLPTVNNQLIYCHSNSRNEFWCALVEKAYAKLAGCYQALDGGNTADALVDFTGGVSEP 236

  Fly   268 YDLKEAP--------GNLFTILQKAAERNSMMGCSIEPDPNVT----EAETPQGLIRGHAYSITK 320
            .||.|..        ..||..:.|...|..::..||:.   ||    ||....||::||||::|.
Human   237 IDLTEGDFANDETKRNQLFERMLKVHSRGGLISASIKA---VTAADMEARLACGLVKGHAYAVTD 298

  Fly   321 VCLI----DIVTPNRQGKIPMIRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFDRDGE 381
            |..:    .::...:..|:.|||:||||| |.||||||||:|.||:.:.:.::.::|:|...|||
Human   299 VRKVRLGHGLLAFFKSEKLDMIRLRNPWG-EREWNGPWSDTSEEWQKVSKSEREKMGVTVQDDGE 362

  Fly   382 FWMSFQDFLNHFDRVEICNLSPDSLTEDQQNSGKRKWEMSMYEGEWT----PGVT-AGGCRNFLD 441
            |||:|:|...:|..:..|.:...|     ..|..:.||.:...|.||    |... .|||.|..|
Human   363 FWMTFEDVCRYFTDIIKCRVINTS-----HLSIHKTWEEARLHGAWTLHEDPRQNRGGGCINHKD 422

  Fly   442 TFWHNPQYIITLVDPDEEDEEGQCTVIVALMQKNRRSKRNMGM-ECLTIGFAIYSLNDRELENRP 505
            ||:.|||||..:..|::|       |::.:.|:.:||.|..|. |.|.|||.||.:.    |||.
Human   423 TFFQNPQYIFEVKKPEDE-------VLICIQQRPKRSTRREGKGENLAIGFDIYKVE----ENRQ 476

  Fly   506 QGLNFFRYKSSVGRSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETQNNMEE 569
            ..::..::|::   |..:||:|.|..|...|.|.|:|:|:||:|...|||::|||::..:|..|
Human   477 YRMHSLQHKAA---SSIYINSRSVFLRTDQPEGRYVIIPTTFEPGHTGEFLLRVFTDVPSNCRE 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpA	NP_001286613.1	Peptidase_C2	104..400	CDD:279042	144/317 (45%)
		Calpain_III	418..565	CDD:279416	57/152 (38%)
		EFh	719..765	CDD:238008
CAPN5	XP_011543527.1	CysPc	53..391	CDD:128526	150/346 (43%)
		Calpain_III	394..533	CDD:279416	57/152 (38%)
		C2_Calpain	555..678	CDD:176011
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4459
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.870