DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CalpA and SRI

DIOPT Version :9

Sequence 1:	NP_001286613.1	Gene:	CalpA / 37232	FlyBaseID:	FBgn0012051	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_003121.1	Gene:	SRI / 6717	HGNCID:	11292	Length:	198	Species:	Homo sapiens

Alignment Length:	264	Identity:	71/264 - (26%)
Similarity:	108/264 - (40%)	Gaps:	87/264 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   575 GYGGKADTITPGFPTPKPIDPQKEGLRRLFDSIAGKDMEVDWMELKRILDHSMRDDLPKPVVFNR 639
            ||||...  .|.|| .:..||    |...|.::||:|.::|..||:|.|..|
Human    17 GYGGAPG--GPAFP-GQTQDP----LYGYFAAVAGQDGQIDADELQRCLTQS------------- 61

  Fly   640 FSNNMAFETQAAGPGDDGAGACGLLSLICGPFLKGTPFEEQLGMNDQSNKRLIGDNPADGGPVTA 704
                               |..|                              |..|
Human    62 -------------------GIAG------------------------------GYKP-------- 69

  Fly   705 NAIVDETHGFSKDVCRSMVAMLDADKSGKLGFEEFETLLSEIAKWKAIFKVYDVENTGRVSGFQL 769
                     |:.:.||.||:|||.|.||.:||.||:.|.:.:..|:..|..:|.:.:|.|...:|
Human    70 ---------FNLETCRLMVSMLDRDMSGTMGFNEFKELWAVLNGWRQHFISFDTDRSGTVDPQEL 125

  Fly   770 REALNSAGYHLNNRVLNVLGHRYGSRDGKIAFDDFIMCAVKIKTYIDIFKERDTEKNETATFTLE 834
            ::||.:.|:.|:.:.:|.:..|| |.:|||.|||:|.|.||::...|.|:.|||.:.....|..:
Human   126 QKALTTMGFRLSPQAVNSIAKRY-STNGKITFDDYIACCVKLRALTDSFRRRDTAQQGVVNFPYD 189

  Fly   835 EWIE 838
            ::|:
Human   190 DFIQ 193

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpA	NP_001286613.1	Peptidase_C2	104..400	CDD:279042
		Calpain_III	418..565	CDD:279416
		EFh	719..765	CDD:238008	19/45 (42%)
SRI	NP_003121.1	EFh_PEF_sorcin	34..198	CDD:320062	63/244 (26%)
		EF-hand motif	34..62	CDD:320062	12/63 (19%)
		EF-hand motif	74..103	CDD:320062	15/28 (54%)
		EF-hand motif	104..133	CDD:320062	8/28 (29%)
		EF-hand motif	140..167	CDD:320062	14/27 (52%)
		EF-hand motif	169..197	CDD:320062	7/25 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910