Protein Alignment CalpA and CAPN15

DIOPT Version :9

• Sequence 1: NP_001286613.1
• Gene: CalpA / 37232
• FlyBaseID: FBgn0012051
• Length: 843
• Species: Drosophila melanogaster
• Sequence 2: XP_011520922.1
• Gene: CAPN15 / 6650
• HGNCID: 11182
• Length: 1162
• Species: Homo sapiens
• Alignment Length: 550
• Identity: 143/550 - (26%)
• Similarity: 213/550 - (38%)
• Gaps: 151/550 - (27%)

  Fly    90 YETILNSCLASGSLFEDPLFPASNESLQF---SRRPDRHIEWLRPHEIAENPQFFVE---GYSRF 148
            :|.|:..|..:...|.|..||...||:.|   .....|..:||||.||  |...|.:   .:|.|
Human   542 WENIVAFCRENNVSFVDDSFPPGPESVGFPAGDSVQQRVRQWLRPQEI--NCSVFRDHRATWSVF 604

  Fly   149 ------DVQQGELGDCWLLAATANLTQESNLFFRVIPAEQSFEENYAGIFHFRFWQYGKWVDVII 207
                  |:.||.||:||.|:|.|.|.:..:|..||:.......|   |.:..|..:.|.|..|::
Human   605 HTLRPSDILQGLLGNCWFLSALAVLAERPDLVERVMVTRSLCAE---GAYQVRLCKDGTWTTVLV 666

  Fly   208 DDRLPTYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCEAMEDFTGGVSEWYDL-- 270
            ||.||......:.....::.:.|.||:|||.|||||||.||:.|...|.:...||...|...|
Human   667 DDMLPCDEAGCLLFSQAQRKQLWVALIEKALAKLHGSYFALQAGRAIEGLATLTGAPCESLALQL 731

  Fly   271 -----KEAPGNLFTILQK---AAERNSMMGCS-----IEPDPNVTEAETPQGLIRGHAYSITKVC 322
                 :|.|.:...|..|   :.|...:||.|     ::.|.:..|:   .||...|||||..|
Human   732 SSTNPREEPVDTDLIWAKMLSSKEAGFLMGASCGGGNMKVDDSAYES---LGLRPRHAYSILDV- 792

  Fly   323 LIDIVTPNRQGKIPMIRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFDRDGEFWMSFQ 387
             .|:     || ..::|:||||| ...|||.|||..|.|   |...:.|:......:|.|||.:.
Human   793 -RDV-----QG-TRLLRLRNPWG-RFSWNGSWSDEWPHW---PGHLRGELMPHGSSEGVFWMEYG 846

  Fly   388 DFLNHFDRVEICNLSPDSLTEDQQNSGKRKWEMSMYEGEWTP------GVTAGGCRNFLDTFWHN 446
            ||:.:||.|:||.:..|             |:.:..:|.:..      ||||
Human   847 DFVRYFDSVDICKVHSD-------------WQEARVQGCFPSSASAPVGVTA------------- 885

  Fly   447 PQYIITLVDPDEEDEEGQCTVIVALMQKNRRSKRNMGMECLTIGFAIYSLNDRELENRPQGLNFF 511
                :|:::        :.::..||.|:..|....:....|.:...:
Human   886 ----LTVLE--------RASLEFALFQEGSRRSDAVDSHLLDLCILV------------------ 920

  Fly   512 RYKSSVGRSPH------FINTREVCARF-----KLPPGHYLIVPSTFDPNEEGEFIIRVFSETQN 565
             ::::.|...|      ..:::....:|     .|.||.|.:|...|
Human   921 -FRATFGSGGHLSLGRLLAHSKRAVKKFVSCDVMLEPGEYAVVCCAF------------------ 966

  Fly   566 NMEENDDHVGYGGKADTITPGFPTPKPIDP 595
                  :|.|      ...||.|.|:...|
Human   967 ------NHWG------PPLPGTPAPQASSP 984

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CalpA	NP_001286613.1	Peptidase_C2	104..400	CDD:279042	110/322 (34%)
		Calpain_III	418..565	CDD:279416	21/163 (13%)
		EFh	719..765	CDD:238008
CAPN15	XP_011520922.1	ZnF_RBZ	73..97	CDD:197784
		RanBP2-type Zn finger	75..94	CDD:275376
		RanBP2-type Zn finger	116..135	CDD:275376
		RanBP2-type Zn finger	169..191	CDD:275375
		ZnF_RBZ	213..237	CDD:197784
		RanBP2-type Zn finger	215..234	CDD:275375
		RanBP2-type Zn finger	412..431	CDD:275376
		ZnF_RBZ	482..506	CDD:197784
		RanBP2-type Zn finger	484..503	CDD:275376
		CysPc	544..859	CDD:238004	112/334 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820