DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CalpA and Capn10

DIOPT Version :9

Sequence 1:	NP_001286613.1	Gene:	CalpA / 37232	FlyBaseID:	FBgn0012051	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_113861.1	Gene:	Capn10 / 63834	RGDID:	69354	Length:	666	Species:	Rattus norvegicus

Alignment Length:	514	Identity:	171/514 - (33%)
Similarity:	248/514 - (48%)	Gaps:	100/514 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 LFEDPLFPASNESL---------QFSRRPDRHIEWLRPHEIAENPQFFVEGYSRFDVQQGELGDC 158
            ||.|..||||:.||         ||  |.|  |.|.||.:|...||.|.:......|:||.||||
  Rat    13 LFRDAAFPASDSSLFYNLSTPLAQF--RED--ITWRRPQDICATPQLFPDNPWEGQVKQGLLGDC 73

  Fly   159 WLLAATANLTQESNLFFRVIPAEQS--FEENYAGIFHFRFWQYGKWVDVIIDDRLPTYNGELMYM 221
            |.|.|.|.|.:..:|..:|.|..|.  .::.|.|.|..|.||:|.|.:|.||||||...|.|.:.
  Rat    74 WFLCACAALQKSRHLLDQVFPPGQPGWSDQEYQGFFTCRIWQFGHWEEVTIDDRLPCLAGRLCFS 138

  Fly   222 HSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCEAMEDFTGGVSEWYDLKEAPGNLFTILQKAA- 285
            ....::.||..||||||||:|||||.|..|...:|:.|.||.::|.:.||:        ::||:
  Rat   139 RCQREDVFWLPLLEKAYAKVHGSYEHLWAGQVADALVDLTGSLAERWSLKD--------IRKASG 195

  Fly   286 --ERNS-----------------MMGCSI-EPDPNVTEAETPQGLIRGHAYSITKVCLIDIVTPN 330
              :|.|                 ::.||: .|.....|      |...||:.|:.  |.::.:..
  Rat   196 QQDRPSGGEHRACQQLLRLKDQCLLSCSVLSPRAGARE------LGEFHAFIISD--LQELRSQT 252

  Fly   331 RQGKIPMIRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFDRDGEFWMSFQDFLNHFDR 395
            .|| |.::|:.||||... |.|.|.:....|..:...:::|: |...::||||:..::||..||.
  Rat   253 GQG-ILLLRIHNPWGRRC-WQGLWREGGEGWNQVEPAKESEL-LAQLQEGEFWVEEEEFLREFDE 314

  Fly   396 VEICNLSPDSLTEDQQNSGKRKWEMSMY-----------EGEWTPGVTAGGCRNFLDTFWHNPQY 449
            |.|    ...:||    :|..:   |:|           .|.|..|.:|||||| ...|..||::
  Rat   315 VTI----GYPVTE----AGHLQ---SLYTEKVLCHTRALPGAWVTGQSAGGCRN-NSCFPCNPKF 367

  Fly   450 IITLVDPDEEDEEGQCTVIVALMQKNRRSKRNMGMECLTIGFAIYSLNDRELENRPQGLNFFRY- 513
            .:.|::|.|        |.||::|:.||  |.:|......|.:...:|....:.:..||:.::.
  Rat   368 WLRLLEPSE--------VCVAVLQRPRR--RLVGQTRALAGASPAPVNLPGKDYQAVGLHIWKVE 422

  Fly   514 --KSSVGR---SPHFINT------REVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFS 561
              |.|:.|   :|....|      ||:..|.:|.||:||.|||||..:..|:|::||||
  Rat   423 KRKISLPRVLSAPPVAGTACHAYDREIHLRCELSPGYYLAVPSTFLKDVPGQFLLRVFS 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpA	NP_001286613.1	Peptidase_C2	104..400	CDD:279042	114/327 (35%)
		Calpain_III	418..565	CDD:279416	53/167 (32%)
		EFh	719..765	CDD:238008
Capn10	NP_113861.1	CysPc	8..319	CDD:238004	115/332 (35%)
		Domain III 1	322..488		56/178 (31%)
		calpain_III	338..488	CDD:214786	51/155 (33%)
		Calpain_III	506..647	CDD:238132
		Domain III 2	507..648
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920