Protein Alignment CalpA and capn10

DIOPT Version :10

• Sequence 1: NP_001286613.1
• Gene: CalpA / 37232
• FlyBaseID: FBgn0012051
• Length: 843
• Species: Drosophila melanogaster
• Sequence 2: XP_073785667.1
• Gene: capn10 / 570311
• ZFINID: ZDB-GENE-110411-137
• Length: 677
• Species: Danio rerio
• Alignment Length: 658
• Identity: 187/658 - (28%)
• Similarity: 280/658 - (42%)
• Gaps: 154/658 - (23%)

  Fly    96 SCLAS-------GSLFEDPLFPASNESL------QFSRRPDRHIEWLRPHEIAENPQFFVEGYSR 147
            :||.|       ..:|.|..|||.:.||      ..|:..| .:.||||.||.:.||.|.:....
Zfish    24 TCLLSMETDTEHHEMFVDQDFPADDLSLFCDYTTPLSKLLD-DVTWLRPQEICKQPQLFPDDSVE 87

  Fly   148 FDVQQGELGDCWLLAATANLTQESNLFFRVIPAEQSF--EENYAGIFHFRFWQYGKWVDVIIDDR 210
            ...:||.|||||||.|.:.|.:..:|..:|.|.||..  :..|.|.|.|||||.|.|::|.:|||
Zfish    88 AHPKQGILGDCWLLCACSMLLKNRHLLDKVFPPEQPLWGDSAYRGEFLFRFWQNGHWIEVRVDDR 152

  Fly   211 LPTYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCEAMEDFTGGVSEWYDLK--EA 273
            ||..|..|.:........||.|||||||||||||||.|..|..||||.|.:|.|:..:.:|  |:
Zfish   153 LPCINDNLCFSRCQSPRAFWVALLEKAYAKLHGSYEHLWAGQVCEAMVDLSGAVAVRWSIKDPES 217

  Fly   274 PGNLFTILQKAAE---RNSMMGCSIEPDP-----------NVTEAET--PQGLIRGHAYSITKVC 322
            |       |:..:   ::::.|.|:...|           .|..|.|  |: |.:.||     :|
Zfish   218 P-------QQPNDSQIQHALHGLSVSDLPLELKERCAISCCVHSATTGFPE-LGQFHA-----MC 269

  Fly   323 LID---IVTPNRQGKIPMIRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFDRDGEFWM 384
            :::   :.|...:| :.:||:|||||..: |.|.|.:....|..: |...|:..|:....|||||
Zfish   270 VMEWTSVTTITGEG-VQLIRIRNPWGRRS-WAGVWRERGSGWASL-EASCAQTLLSRTAKGEFWM 331

  Fly   385 SFQDFLNHFDRVEI-CNLSP----------DSLTEDQQNSGKRKWEMSMYEGEWTPGVTAGGCRN 438
            ...:||..||.|.: |.::.          :.||..||..|:           |..|.:||||||
Zfish   332 DEAEFLQEFDEVTVGCPVNDAGHLQSIYTGNFLTHSQQIGGR-----------WVKGYSAGGCRN 385

  Fly   439 FLDTFWHNPQYIITLVDPDEEDEEGQCTVIVALMQKNRRSKRNMG-----MECLTIGFAIYSLND 498
             ..||..||::.:.:.:..|        |.::|:|..|......|     .:...|...::.:..
Zfish   386 -NSTFSSNPKFWLKVCERGE--------VFLSLLQCRRAESPAEGAIQQHTQLQAIALHVWKVEK 441

  Fly   499 RELENRPQGLNFFRYKSSVGRSPHFIN-----TREVCARFKLPPGHYLIVPSTFDPNEEGEFIIR 558
            :.          |....::.:.| |::     .|||.....|.||.||:|||||....||.|::|
Zfish   442 KH----------FNLTRTLNKQP-FVSHAHAYDREVVVHTHLNPGFYLLVPSTFLQGAEGPFLLR 495

  Fly   559 VFSETQNNMEENDDHVGYGGKADTITPGFPTPKPIDPQKE-------GLRRLFDSIAGKDMEVDW 616
            |.|....::              ::....|:|..:..:.|       |...:..|..|.
Zfish   496 VHSSCSTSL--------------SVMKSSPSPLQLSSEGEWENICSHGSWSIGSSAGGS------ 540

  Fly   617 MELKRILDHSMRDDLPKPVVFNRFSNNMAFETQAAGP--------------GDDGAGAC---GLL 664
               :....|.:...:...|:::...||:........|              .|.|:|:.   |::
Zfish   541 ---RNFTTHELNPRVNLTVIYDPGGNNVRVTLHQNRPENSLHPIGFHIYKVPDGGSGSLLSPGVM 602

  Fly   665 SLI--CGP 670
            |.:  |.|
Zfish   603 SPVVSCVP 610

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CalpA	NP_001286613.1	Peptidase_C2	104..400	CDD:459889	119/325 (37%)
		Calpain_III	416..569	CDD:238132	41/162 (25%)
		EFh_PEF_CalpA_B	600..843	CDD:320071	14/90 (16%)
		EF-hand motif	600..627	CDD:320071	3/26 (12%)
		EF-hand motif	717..747	CDD:320071
		EF-hand motif	748..778	CDD:320071
		EF-hand motif	784..812	CDD:320071
		EF-hand motif	813..843	CDD:320071
capn10	XP_073785667.1	None