Protein Alignment CalpA and si:dkey-19b23.12

DIOPT Version :10

• Sequence 1: NP_001286613.1
• Gene: CalpA / 37232
• FlyBaseID: FBgn0012051
• Length: 843
• Species: Drosophila melanogaster
• Sequence 2: NP_001373571.1
• Gene: si:dkey-19b23.12 / 568864
• ZFINID: ZDB-GENE-141216-440
• Length: 725
• Species: Danio rerio
• Alignment Length: 765
• Identity: 233/765 - (30%)
• Similarity: 333/765 - (43%)
• Gaps: 203/765 - (26%)

  Fly    88 QDYETILNSCLASGSLFEDPLFPASNESLQFSRRPDRHIEWLRPHEIAENPQFFVEGYSRFDVQQ 152
            |.|..:..|||..|:||:|||||.|.|||.:.|.|...:.|.||.|:.::|:.||:|.|..|:.|
Zfish    11 QCYHKLKRSCLRRGALFQDPLFPPSAESLFYRRTPPPGLTWKRPSELCKDPRLFVDGISTRDLHQ 75

  Fly   153 GELGDCWLLAATANLTQESNLFFRVIP--AEQSFE----ENYAGIFHFRFWQYGKWVDVIIDDRL 211
            |.||:||::|||:.|..||:|:.:|||  .||.:.    :.||||||||||:.|:|.||::||||
Zfish    76 GSLGNCWMVAATSCLAAESSLWKKVIPDHTEQEWHPKRPDLYAGIFHFRFWRLGQWTDVVVDDRL 140

  Fly   212 P-TYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCEAMEDFTGGVSEWYDLKEAP- 274
            | :.:|.|::..|....||||||||||||||:|.||||:||:|.||:.||||||||...|.:..
Zfish   141 PVSGDGTLLFCRSATPREFWSALLEKAYAKLNGCYEALEGGNTAEALVDFTGGVSEPLSLNQEEL 205

  Fly   275 -------GNLFTILQKAAERNSMMGCSIEP-DPNVTEAETPQGLIRGHAYSITKV---------- 321
                   ..||..|..|....:::.|||.| :....|:....|||:||||.:|.|
Zfish   206 IQHADQRKILFQTLAHAHSHKALITCSIRPAEGEALESVLDCGLIKGHAYGVTAVKKLRMSETLH 270

  Fly   322 --CLIDIVTPNRQGKIPMIRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFDRDGEFWM 384
              |        ...::.|:|:|||||. .:|.|.|...||||:....::|.::||.....|||||
Zfish   271 SMC--------NASRLYMVRIRNPWGT-TDWTGAWGLGSPEWQQFNRKEKEKMGLIVRDVGEFWM 326

  Fly   385 SFQDFLNHFDRVEICNLSPDSLTEDQQNSGKRKWEMSMYEGEW--TPGV---------------- 431
            .|:||..:|..:.:|.|:..||...|.:     |......|.|  |.|:
Zfish   327 EFEDFCRYFTDMVVCRLAEKSLLWPQSH-----WREVCCHGAWTFTSGIPTFPSSSYCLNIKNQR 386

  Fly   432 ----------------------------------------------------------------- 431
                                                                             
Zfish   387 PPSGLQWSKQRPAQRRDKKEQRLSERQREGRIQGEKLTKIDNAEIKPKQIKDRKECVKELEGGME 451

  Fly   432 -----------TAGGCRNFLDTFWHNPQYIITLVDPDEEDEEGQCTVIVALMQKNRRSKRNMGM- 484
                       ..|||.|..|||.||||::..|....||       |::.|.|::||.||..|.
Zfish   452 MRWDMQIDRRTRCGGCINHRDTFLHNPQFLFELFGGGEE-------VLICLQQEDRRMKRREGSG 509

  Fly   485 ECLTIGFAIYSLNDRELENRPQGLNFFRYKSSVGRSPHFINTREVCARFKLPPGHYLIVPSTFDP 549
            |.|.|||.:..:....: .|.|.| ..:..|||     ::::|.|..|..|.||.|:|:|:||.|
Zfish   510 ENLPIGFEVLRVEVNRV-CRVQCL-CEQTASSV-----YMDSRSVTLRVTLGPGRYVILPTTFQP 567

  Fly   550 NEEGEFIIRVFSETQNNMEENDDH----------VGYGGKADTI----TPGFPTPKPIDPQKEGL 600
            ...|.|::|.||.:...:.|..:.          :.......|:    ..|...||...|....:
Zfish   568 GATGRFLLRFFSHSHVRLRELKEELPAPSMWRCCIPDSSAVTTVHLLKASGLSHPKKTAPDVYAI 632

  Fly   601 RRL-FDSIAGKDMEVDWMELKRILDHSMRDDLP----KPVVFNR-FSNNMAFETQAAGPGDDGAG 659
            .|. .||:..:..:              :|:.|    |.:.::| ..:.::.|....|
Zfish   633 IRCEEDSVRTRVFK--------------KDESPEFNTKAIFYSRKLKSKISIELWRRG------- 676

  Fly   660 ACGLLSLICGPFLKGTPFEEQLGMNDQSNKRLIGDNPADGGPVTANAIVD 709
                  |:...||.|...  |.|.:::...|:|   ...||....:..|:
Zfish   677 ------LLLDTFLGGARL--QTGGSERGQNRVI---DLQGGQSRGSVFVE 715

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CalpA	NP_001286613.1	Peptidase_C2	104..400	CDD:459889	140/323 (43%)
		Calpain_III	416..569	CDD:238132	55/247 (22%)
		EFh_PEF_CalpA_B	600..843	CDD:320071	20/116 (17%)
		EF-hand motif	600..627	CDD:320071	3/27 (11%)
		EF-hand motif	717..747	CDD:320071
		EF-hand motif	748..778	CDD:320071
		EF-hand motif	784..812	CDD:320071
		EF-hand motif	813..843	CDD:320071
si:dkey-19b23.12	NP_001373571.1	Peptidase_C2	27..342	CDD:459889	140/323 (43%)
		Calpain_III	453..578	CDD:460050	48/138 (35%)
		C2_Calpain	605..723	CDD:176011	25/143 (17%)