DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CalpA and si:ch211-202f3.4

DIOPT Version :9

Sequence 1:	NP_001286613.1	Gene:	CalpA / 37232	FlyBaseID:	FBgn0012051	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	XP_009291546.1	Gene:	si:ch211-202f3.4 / 560088	ZFINID:	ZDB-GENE-131120-116	Length:	523	Species:	Danio rerio

Alignment Length:	530	Identity:	203/530 - (38%)
Similarity:	292/530 - (55%)	Gaps:	43/530 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 NSTLYYGNLGEKSSSLGP-YSEVQDYETILNSCLASGSLFEDPLFPASNESL-QFSRRPDR---- 124
            |:..:..|..|..|...| |...|:|:.:...||...:|:.|.|||..|.|: .|...|..
Zfish     5 NNCHHNPNEDEVDSLTSPLYFLDQNYQELQQKCLTESTLYSDELFPPDNSSIGLFDEVPPEVDMS 69

  Fly   125 HIEWLRPHEIAENPQFFVEGYSRFDVQQGE-LGDCWLLAATANLTQESNLFFRVIPAEQSFEENY 188
            .|.|.||.|:..:|...|:..||||..||. ||:||.||:...||.|.::..:|:||||||.::|
Zfish    70 QIVWKRPSELVSDPNLIVDDVSRFDYAQGSVLGNCWFLASIGALTFEKDIMKQVLPAEQSFTKDY 134

  Fly   189 AGIFHFRFWQYGKWVDVIIDDRLPTYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGST 253
            |||||||||::.||:||:|||:|||.:.||:::.|...||||.|||||||||:.|||..|..|..
Zfish   135 AGIFHFRFWRFEKWIDVVIDDQLPTIDDELLFVCSKTSNEFWPALLEKAYAKVCGSYADLNAGFI 199

  Fly   254 CEAMEDFTGGVSEWYDLKEAPGNLFTILQKAAERNSMMGCSIEPDPNVTEAETPQGLIRGHAYSI 318
            .||:.|||||...:|.|..||.:|:.|::.|....:::||....:.:..|.|...|:|..|||::
Zfish   200 SEALMDFTGGTHMYYTLSSAPADLWKIMECAFISKTLIGCGSNSEGSPEENELLHGIIADHAYTV 264

  Fly   319 TKVCLIDIVTPNRQGKIPMIRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQK---AEIGLTFDRDG 380
            |.|  .:::  :.:..:.::|:.||||.| ||.|.|||.||.|..:.||.:   .|:    ..||
Zfish   265 TGV--FEVI--SEENPVQLVRLLNPWGEE-EWQGDWSDESPLWETVCEEARKCCREV----LNDG 320

  Fly   381 EFWMSFQDFLNHFDRVEICNLSPDSLTEDQQNSGKRKWEMSMYEGEWTP----------GVTAGG 435
            |||||.:||...|:.::||.|.||.|    ..|....|....:.|.|..          .:||||
Zfish   321 EFWMSMEDFTRLFESIDICCLCPDFL----DGSSDCHWTSKRHFGRWNAEKFMYNTFIHHLTAGG 381

  Fly   436 CRNFLDTFWHNPQYIITLVDPDEEDEEGQC--TVIVALMQKNRRSKRNMGMECLTIGFAIYSLND 498
            .....:|||.|||:.:|:.:.:|:...||.  .::|:|||.:.:..|| ..|...|||.::.:
Zfish   382 DIIKTETFWKNPQFRVTIDELNEDCASGQRPENILVSLMQNHEKRNRN-SQENYDIGFYVFEI-- 443

  Fly   499 RELENRPQ----GLNFFRYKSSVGRSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRV 559
             .||.|.|    .:.||..:..|..:...:..|||...|:|.||.|||||.|.:|.|...|::.|
Zfish   444 -PLEMRHQNERFAMEFFADREPVAHTDDLVWLREVMKFFRLEPGEYLIVPCTKNPGETASFVLSV 507

  Fly   560 FSETQNNMEE 569
            ||:.:.::|:
Zfish   508 FSKHETHLEQ 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CalpA	NP_001286613.1	Peptidase_C2	104..400	CDD:279042	132/304 (43%)
		Calpain_III	418..565	CDD:279416	53/162 (33%)
		EFh	719..765	CDD:238008
si:ch211-202f3.4	XP_009291546.1	Peptidase_C2	44..339	CDD:279042	131/303 (43%)
si:ch211-202f3.4	XP_009291546.1	Calpain_III	354..513	CDD:279416	53/162 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.920